{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Corneal+Ectasia",
    "query": {
      "condition": "Corneal Ectasia"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 44,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Corneal+Ectasia&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T13:37:00.914Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04667572",
      "title": "Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Keratoconus",
        "Pellucid Marginal Corneal Degeneration",
        "Corneal Degeneration",
        "Corneal Ectasia"
      ],
      "interventions": [
        {
          "name": "PXL-330 Platinum device for crosslinking with Peschke riboflavin solution",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Cornea Associates of Texas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "8 Years and older"
      },
      "enrollment_count": 249,
      "start_date": "2021-02-01",
      "completion_date": "2024-08-21",
      "has_results": false,
      "last_update_posted_date": "2025-02-11",
      "last_synced_at": "2026-06-26T13:37:00.914Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04667572"
    },
    {
      "nct_id": "NCT03030755",
      "title": "Corneal Elastography and Patient Specific Modeling",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cornea; Ectasia",
        "Refractive Errors",
        "Keratoconus"
      ],
      "interventions": [
        {
          "name": "Optical coherence tomography",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "The Cleveland Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "16 Years to 80 Years"
      },
      "enrollment_count": 60,
      "start_date": "2016-05",
      "completion_date": "2027-05",
      "has_results": false,
      "last_update_posted_date": "2026-06-03",
      "last_synced_at": "2026-06-26T13:37:00.914Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03030755"
    },
    {
      "nct_id": "NCT03918408",
      "title": "Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Keratoconus, Unstable",
        "Bacterial Keratitis",
        "Ectasia of Cornea"
      ],
      "interventions": [
        {
          "name": "PXL-330 Platinum device for crosslinking with Peschke ribofflavin solution",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Pacific Clear Vision Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "12 Years to 45 Years"
      },
      "enrollment_count": 300,
      "start_date": "2019-09-01",
      "completion_date": "2030-12",
      "has_results": false,
      "last_update_posted_date": "2024-11-12",
      "last_synced_at": "2026-06-26T13:37:00.914Z",
      "location_count": 1,
      "location_summary": "Eugene, Oregon",
      "locations": [
        {
          "city": "Eugene",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03918408"
    },
    {
      "nct_id": "NCT01112072",
      "title": "Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Keratoconus",
        "Corneal Ectasia"
      ],
      "interventions": [
        {
          "name": "Riboflavin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cornea and Laser Eye Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 160,
      "start_date": "2010-04",
      "completion_date": "2025-12",
      "has_results": false,
      "last_update_posted_date": "2023-02-08",
      "last_synced_at": "2026-06-26T13:37:00.914Z",
      "location_count": 1,
      "location_summary": "Teaneck, New Jersey",
      "locations": [
        {
          "city": "Teaneck",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01112072"
    },
    {
      "nct_id": "NCT04240457",
      "title": "Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Conditions",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Keratoconus",
        "Cornea Ectasia"
      ],
      "interventions": [
        {
          "name": "Epithelial-on Corneal Crosslinking with the PXL 330 Platinum system.",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Arbor Center for Eye Care",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "12 Years to 60 Years"
      },
      "enrollment_count": 11,
      "start_date": "2020-07-08",
      "completion_date": "2023-02-18",
      "has_results": true,
      "last_update_posted_date": "2024-12-12",
      "last_synced_at": "2026-06-26T13:37:00.914Z",
      "location_count": 1,
      "location_summary": "Orland Park, Illinois",
      "locations": [
        {
          "city": "Orland Park",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04240457"
    },
    {
      "nct_id": "NCT02009709",
      "title": "Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Keratoconus",
        "Corneal Ectasia"
      ],
      "interventions": [
        {
          "name": "Riboflavin 0.1% ophthalmic solution",
          "type": "DRUG"
        },
        {
          "name": "CCL-VARIO UV lamp",
          "type": "DEVICE"
        },
        {
          "name": "CCL-VARIO at 18 mW/cm2",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Robert Mack, M.D.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 100,
      "start_date": "2013-10",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2015-12-14",
      "last_synced_at": "2026-06-26T13:37:00.914Z",
      "location_count": 1,
      "location_summary": "Hoffman Estates, Illinois",
      "locations": [
        {
          "city": "Hoffman Estates",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02009709"
    },
    {
      "nct_id": "NCT03319082",
      "title": "Observational Registry to Assess the Durability of Effect of CXL in Patients With Corneal Ectasia After Refractive Surgery",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Corneal Ectasia"
      ],
      "interventions": [
        {
          "name": "Corneal Collagen Cross-linking",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Glaukos Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2017-10-04",
      "completion_date": "2026-02",
      "has_results": false,
      "last_update_posted_date": "2024-02-23",
      "last_synced_at": "2026-06-26T13:37:00.914Z",
      "location_count": 11,
      "location_summary": "Palo Alto, California • Bloomington, Minnesota • Bozeman, Montana + 8 more",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Bloomington",
          "state": "Minnesota"
        },
        {
          "city": "Bozeman",
          "state": "Montana"
        },
        {
          "city": "West Fargo",
          "state": "North Dakota"
        },
        {
          "city": "Westerville",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03319082"
    },
    {
      "nct_id": "NCT01384773",
      "title": "Progressive Keratoconus or Ectasia Treatment Plan",
      "overall_status": "NO_LONGER_AVAILABLE",
      "study_type": "EXPANDED_ACCESS",
      "phases": [],
      "conditions": [
        "Keratoconus",
        "Ectasia"
      ],
      "interventions": [
        {
          "name": "Riboflavin Solution",
          "type": "OTHER"
        },
        {
          "name": "UV-X Illumination System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "Stephen Trokel",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": null,
      "start_date": null,
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2023-02-09",
      "last_synced_at": "2026-06-26T13:37:00.914Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01384773"
    },
    {
      "nct_id": "NCT05027295",
      "title": "Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Keratoconus",
        "Corneal Ectasia"
      ],
      "interventions": [
        {
          "name": "riboflavin ophthalmic solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cornea and Laser Eye Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 170,
      "start_date": "2021-07-30",
      "completion_date": "2025-07",
      "has_results": false,
      "last_update_posted_date": "2023-01-04",
      "last_synced_at": "2026-06-26T13:37:00.914Z",
      "location_count": 1,
      "location_summary": "Teaneck, New Jersey",
      "locations": [
        {
          "city": "Teaneck",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05027295"
    },
    {
      "nct_id": "NCT01097447",
      "title": "Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Keratoconus",
        "Ectasia",
        "Degeneration"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Cxlusa",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "8 Years and older"
      },
      "enrollment_count": 2619,
      "start_date": "2009-12-01",
      "completion_date": "2017-04-30",
      "has_results": false,
      "last_update_posted_date": "2018-10-11",
      "last_synced_at": "2026-06-26T13:37:00.914Z",
      "location_count": 5,
      "location_summary": "San Diego, California • Littleton, Colorado • Hoffman Estates, Illinois + 2 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Littleton",
          "state": "Colorado"
        },
        {
          "city": "Hoffman Estates",
          "state": "Illinois"
        },
        {
          "city": "Bloomington",
          "state": "Minnesota"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01097447"
    }
  ]
}