{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Corneal+Endothelial+Cell+Loss",
    "query": {
      "condition": "Corneal Endothelial Cell Loss"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-27T13:16:28.377Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02128113",
      "title": "RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Corneal Endothelial Cell Loss",
        "Ocular Pain",
        "Ocular Inflammation",
        "Cataract Surgery"
      ],
      "interventions": [
        {
          "name": "Vehicle Ophthalmic Solution",
          "type": "DRUG"
        },
        {
          "name": "Omaveloxolone Ophthalmic Suspension 0.5%",
          "type": "DRUG"
        },
        {
          "name": "Omaveloxolone Ophthalmic Suspension 1%",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Biogen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 307,
      "start_date": "2014-05-31",
      "completion_date": "2015-04-30",
      "has_results": true,
      "last_update_posted_date": "2025-06-03",
      "last_synced_at": "2026-06-27T13:16:28.377Z",
      "location_count": 15,
      "location_summary": "Laguna Hills, California • Lancaster, California • Cape Coral, Florida + 11 more",
      "locations": [
        {
          "city": "Laguna Hills",
          "state": "California"
        },
        {
          "city": "Lancaster",
          "state": "California"
        },
        {
          "city": "Cape Coral",
          "state": "Florida"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Hoffman Estates",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02128113"
    },
    {
      "nct_id": "NCT06261346",
      "title": "Plasma Rich in Growth Factors in Corneal Endothelial Transplantation",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fuchs' Endothelial Dystrophy",
        "Corneal Edema"
      ],
      "interventions": [
        {
          "name": "Endothelial keratoplasty",
          "type": "PROCEDURE"
        },
        {
          "name": "PRGF",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "BIOLOGICAL"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 100,
      "start_date": "2024-07-15",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-09",
      "last_synced_at": "2026-06-27T13:16:28.377Z",
      "location_count": 2,
      "location_summary": "Miami, Florida • Indianapolis, Indiana",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06261346"
    },
    {
      "nct_id": "NCT02138266",
      "title": "Comparative Study of Specular Microscopes for Endothelial and Corneal Cell Measurements",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Corneal Endothelial Cell Loss"
      ],
      "interventions": [
        {
          "name": "Topcon Specular Microscope SP-1P",
          "type": "DEVICE"
        },
        {
          "name": "Konan Specular Microscope CELLCHEK XL",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Topcon Medical Systems, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 65,
      "start_date": "2014-02",
      "completion_date": "2014-09",
      "has_results": false,
      "last_update_posted_date": "2022-06-08",
      "last_synced_at": "2026-06-27T13:16:28.377Z",
      "location_count": 1,
      "location_summary": "Andover, Massachusetts",
      "locations": [
        {
          "city": "Andover",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02138266"
    },
    {
      "nct_id": "NCT00932191",
      "title": "Endothelial Cell Loss After Cataract Surgery",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Cataracts"
      ],
      "interventions": [
        {
          "name": "Standard phacoemulsification",
          "type": "PROCEDURE"
        },
        {
          "name": "Reduced ultrasound phacoemulsification",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 39,
      "start_date": "2009-07",
      "completion_date": "2012-07",
      "has_results": false,
      "last_update_posted_date": "2014-08-25",
      "last_synced_at": "2026-06-27T13:16:28.377Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00932191"
    },
    {
      "nct_id": "NCT07217249",
      "title": "Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fuchs Endothelial Corneal Dystrophy",
        "Corneal Endothelial Decompensation"
      ],
      "interventions": [
        {
          "name": "Descemet membrane endothelial keratoplasty",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "93 Years",
        "sex": "ALL",
        "summary": "30 Years to 93 Years"
      },
      "enrollment_count": 570,
      "start_date": "2025-12-03",
      "completion_date": "2030-04-30",
      "has_results": false,
      "last_update_posted_date": "2026-02-27",
      "last_synced_at": "2026-06-27T13:16:28.377Z",
      "location_count": 14,
      "location_summary": "Atlanta, Georgia • Indianapolis, Indiana • Iowa City, Iowa + 10 more",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Overland Park",
          "state": "Kansas"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07217249"
    },
    {
      "nct_id": "NCT02276638",
      "title": "Comparative Study of Specular Microscopes for Measurements of Cell Density, Coefficient of Variation and Hexagonality",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Corneal Endothelial Cell Loss"
      ],
      "interventions": [
        {
          "name": "Specular Microscope Nidek CEM-530",
          "type": "DEVICE"
        },
        {
          "name": "Specular Microscope Konan CELLCHEK XL",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Nidek Co. LTD.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 79,
      "start_date": "2014-09",
      "completion_date": "2014-10",
      "has_results": true,
      "last_update_posted_date": "2019-03-20",
      "last_synced_at": "2026-06-27T13:16:28.377Z",
      "location_count": 1,
      "location_summary": "Andover, Massachusetts",
      "locations": [
        {
          "city": "Andover",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02276638"
    },
    {
      "nct_id": "NCT02427256",
      "title": "Second Comparative Study of Specular Microscopes for Endothelial and Corneal Cell Measurements",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Corneal Endothelial Cell Loss"
      ],
      "interventions": [
        {
          "name": "Topcon Specular Microscope SP-1P",
          "type": "DEVICE"
        },
        {
          "name": "Konan Specular Microscope CELLCHEK XL",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Topcon Medical Systems, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 76,
      "start_date": "2015-02",
      "completion_date": "2015-02",
      "has_results": false,
      "last_update_posted_date": "2022-06-08",
      "last_synced_at": "2026-06-27T13:16:28.377Z",
      "location_count": 1,
      "location_summary": "Andover, Massachusetts",
      "locations": [
        {
          "city": "Andover",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02427256"
    },
    {
      "nct_id": "NCT05134480",
      "title": "Impact of Donor Diabetes on DMEK Success and Endothelial Cell Loss",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Corneal Endothelial Decompensation",
        "Fuchs' Endothelial Dystrophy"
      ],
      "interventions": [
        {
          "name": "Descemet membrane endothelial keratoplasty",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "30 Years to 90 Years"
      },
      "enrollment_count": 1097,
      "start_date": "2022-01-21",
      "completion_date": "2025-09-15",
      "has_results": true,
      "last_update_posted_date": "2026-04-16",
      "last_synced_at": "2026-06-27T13:16:28.377Z",
      "location_count": 2,
      "location_summary": "Indianapolis, Indiana • Grand Rapids, Michigan",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Grand Rapids",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05134480"
    },
    {
      "nct_id": "NCT01250964",
      "title": "Endothelial Cell Loss and Induced Astigmatism After Wound-directed and Wound-assisted IOL Injection",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cataracts",
        "Cataract Surgery"
      ],
      "interventions": [
        {
          "name": "Lens insertion during cataract surgery",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 72,
      "start_date": "2010-04",
      "completion_date": "2010-11",
      "has_results": false,
      "last_update_posted_date": "2010-12-01",
      "last_synced_at": "2026-06-27T13:16:28.377Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01250964"
    },
    {
      "nct_id": "NCT02096627",
      "title": "Comparison of Femtosecond Laser Assisted Cataract Surgery to Conventional Phacoemulsification Cataract Surgery",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cataract"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 154,
      "start_date": "2014-05",
      "completion_date": "2018-11",
      "has_results": false,
      "last_update_posted_date": "2018-11-16",
      "last_synced_at": "2026-06-27T13:16:28.377Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02096627"
    }
  ]
}