{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Corneal+Endothelial+Disorder",
    "query": {
      "condition": "Corneal Endothelial Disorder"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 65,
    "total_pages": 7,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Corneal+Endothelial+Disorder&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-22T05:14:51.143Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01537393",
      "title": "Cornea Preservation Time Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Cornea Preservation Time",
        "Endothelial Keratoplasty",
        "Transplant Success",
        "Endothelial Cell Density"
      ],
      "interventions": [
        {
          "name": "Cornea tissue transplant",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "30 Years to 90 Years"
      },
      "enrollment_count": 1174,
      "start_date": "2012-04-16",
      "completion_date": "2017-06-30",
      "has_results": true,
      "last_update_posted_date": "2018-04-23",
      "last_synced_at": "2026-09-22T05:14:51.143Z",
      "location_count": 40,
      "location_summary": "Beverly Hills, California • Los Angeles, California • San Diego, California + 35 more",
      "locations": [
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01537393"
    },
    {
      "nct_id": "NCT00624221",
      "title": "Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fuchs Endothelial Dystrophy",
        "Corneal Edema"
      ],
      "interventions": [
        {
          "name": "Descemet's stripping endothelial keratoplasty",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Cornea Research Foundation of America",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2006-01",
      "completion_date": "2007-11",
      "has_results": true,
      "last_update_posted_date": "2016-04-27",
      "last_synced_at": "2026-09-22T05:14:51.143Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00624221"
    },
    {
      "nct_id": "NCT02138266",
      "title": "Comparative Study of Specular Microscopes for Endothelial and Corneal Cell Measurements",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Corneal Endothelial Cell Loss"
      ],
      "interventions": [
        {
          "name": "Topcon Specular Microscope SP-1P",
          "type": "DEVICE"
        },
        {
          "name": "Konan Specular Microscope CELLCHEK XL",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Topcon Medical Systems, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 65,
      "start_date": "2014-02",
      "completion_date": "2014-09",
      "has_results": false,
      "last_update_posted_date": "2022-06-08",
      "last_synced_at": "2026-09-22T05:14:51.143Z",
      "location_count": 1,
      "location_summary": "Andover, Massachusetts",
      "locations": [
        {
          "city": "Andover",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02138266"
    },
    {
      "nct_id": "NCT04258787",
      "title": "OCT in Fuchs' Dystrophy",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fuchs Dystrophy",
        "Pseudophakic Bullous Keratopathy"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2020-06-26",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2025-09-09",
      "last_synced_at": "2026-09-22T05:14:51.143Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04258787"
    },
    {
      "nct_id": "NCT04175938",
      "title": "Assessment of Corneal Endothelial Function Following Hypoxic Stress",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Fuchs' Endothelial Corneal Dystrophy"
      ],
      "interventions": [
        {
          "name": "Wearing of contact lens",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts Eye and Ear Infirmary",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2025-12",
      "completion_date": "2027-11-30",
      "has_results": false,
      "last_update_posted_date": "2026-03-02",
      "last_synced_at": "2026-09-22T05:14:51.143Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04175938"
    },
    {
      "nct_id": "NCT07729137",
      "title": "Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Corneal Edema",
        "Fuchs",
        "Fuchs Dystrophy",
        "Fuchs' Endothelial Dystrophy",
        "Endothelial Corneal Dystrophy",
        "Corneal Endothelial Decompensation",
        "Corneal Endothelial Cell Loss",
        "Corneal Endothelial Disorder",
        "Corneal Endothelial Dystrophy 1",
        "Endothelial Cell Loss, Corneal",
        "Pseudophakic Bullous Keratopathy",
        "Pseudophakic Bullous Keratopathy (PBK)"
      ],
      "interventions": [
        {
          "name": "150K cells",
          "type": "BIOLOGICAL"
        },
        {
          "name": "500K cells",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "PROCEDURE"
      ],
      "sponsor": "Emmecell",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 121,
      "start_date": "2026-09",
      "completion_date": "2028-02",
      "has_results": false,
      "last_update_posted_date": "2026-07-29",
      "last_synced_at": "2026-09-22T05:14:51.143Z",
      "location_count": 1,
      "location_summary": "Menlo Park, California",
      "locations": [
        {
          "city": "Menlo Park",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07729137"
    },
    {
      "nct_id": "NCT05134480",
      "title": "Impact of Donor Diabetes on DMEK Success and Endothelial Cell Loss",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Corneal Endothelial Decompensation",
        "Fuchs' Endothelial Dystrophy"
      ],
      "interventions": [
        {
          "name": "Descemet membrane endothelial keratoplasty",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "30 Years to 90 Years"
      },
      "enrollment_count": 1097,
      "start_date": "2022-01-21",
      "completion_date": "2025-09-15",
      "has_results": true,
      "last_update_posted_date": "2026-04-16",
      "last_synced_at": "2026-09-22T05:14:51.143Z",
      "location_count": 2,
      "location_summary": "Indianapolis, Indiana • Grand Rapids, Michigan",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Grand Rapids",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05134480"
    },
    {
      "nct_id": "NCT06565650",
      "title": "A Study to Evaluate Corneal Endothelial Cell Density (ECD) in Subjects With Dry Eye Disease (DED) Administering Miebo® (Perfluorohexyloctane Ophthalmic Solution) for 12 Months.",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Dry Eye"
      ],
      "interventions": [
        {
          "name": "Miebo",
          "type": "DRUG"
        },
        {
          "name": "Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Bausch & Lomb Incorporated",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 216,
      "start_date": "2024-07-31",
      "completion_date": "2025-11",
      "has_results": false,
      "last_update_posted_date": "2024-12-17",
      "last_synced_at": "2026-09-22T05:14:51.143Z",
      "location_count": 12,
      "location_summary": "Glendale, California • Murrieta, California • Newport Beach, California + 9 more",
      "locations": [
        {
          "city": "Glendale",
          "state": "California"
        },
        {
          "city": "Murrieta",
          "state": "California"
        },
        {
          "city": "Newport Beach",
          "state": "California"
        },
        {
          "city": "Rancho Cordova",
          "state": "California"
        },
        {
          "city": "Torrance",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06565650"
    },
    {
      "nct_id": "NCT04752020",
      "title": "Netarsudil Use After Descemtorhexis Without Endothelial Keratoplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Fuchs' Endothelial Dystrophy"
      ],
      "interventions": [
        {
          "name": "Netarsudil Ophthalmic",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts Eye and Ear Infirmary",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2021-03-28",
      "completion_date": "2023-12-30",
      "has_results": false,
      "last_update_posted_date": "2024-03-13",
      "last_synced_at": "2026-09-22T05:14:51.143Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04752020"
    },
    {
      "nct_id": "NCT04894110",
      "title": "Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Corneal Edema",
        "Corneal Endothelial Dysfunction",
        "Corneal Endothelial Dystrophy",
        "Fuchs Dystrophy",
        "Fuchs Endothelial Corneal Dystrophy",
        "Pseudophakic Bullous Keratopathy",
        "Bullous Keratopathy",
        "Endothelial Dysfunction",
        "Moderate Corneal Endothelial Decompensation"
      ],
      "interventions": [
        {
          "name": "EO2002",
          "type": "BIOLOGICAL"
        },
        {
          "name": "EO2002 low dose",
          "type": "BIOLOGICAL"
        },
        {
          "name": "EO2002 mid dose",
          "type": "BIOLOGICAL"
        },
        {
          "name": "EO2002 high dose",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Emmecell",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 42,
      "start_date": "2021-06-22",
      "completion_date": "2024-10-03",
      "has_results": false,
      "last_update_posted_date": "2025-03-05",
      "last_synced_at": "2026-09-22T05:14:51.143Z",
      "location_count": 8,
      "location_summary": "Greater Los Angeles, California • San Diego, California • Miami, Florida + 5 more",
      "locations": [
        {
          "city": "Greater Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Palm Beach Gardens",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04894110"
    }
  ]
}