{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Corneal+Endothelial+Dysfunction",
    "query": {
      "condition": "Corneal Endothelial Dysfunction"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 6,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T08:10:59.774Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06041256",
      "title": "A Phase 1/2 Study of AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction (ABA-1)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Corneal Edema",
        "Corneal Endothelial Dysfunction"
      ],
      "interventions": [
        {
          "name": "AURN001",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Corneal Endothelial Cells",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Y27632",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT",
        "BIOLOGICAL",
        "DRUG"
      ],
      "sponsor": "Aurion Biotech",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 97,
      "start_date": "2023-10-18",
      "completion_date": "2025-04-15",
      "has_results": true,
      "last_update_posted_date": "2025-12-17",
      "last_synced_at": "2026-05-22T08:10:59.774Z",
      "location_count": 17,
      "location_summary": "Little Rock, Arkansas • Los Angeles, California • San Francisco, California + 13 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06041256"
    },
    {
      "nct_id": "NCT04527523",
      "title": "Descemet Membrane Endothelial Keratoplasty vs. Descemet's Stripping With Endothelial Keratoplasty vs. Descemet Stripping Only",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cystoid Macular Edema",
        "Fuchs Dystrophy"
      ],
      "interventions": [
        {
          "name": "Optical Coherence Tomography",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4,
      "start_date": "2020-11-21",
      "completion_date": "2022-08-24",
      "has_results": false,
      "last_update_posted_date": "2023-01-13",
      "last_synced_at": "2026-05-22T08:10:59.774Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04527523"
    },
    {
      "nct_id": "NCT04894110",
      "title": "Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Corneal Edema",
        "Corneal Endothelial Dysfunction",
        "Corneal Endothelial Dystrophy",
        "Fuchs Dystrophy",
        "Fuchs Endothelial Corneal Dystrophy",
        "Pseudophakic Bullous Keratopathy",
        "Bullous Keratopathy",
        "Endothelial Dysfunction",
        "Moderate Corneal Endothelial Decompensation"
      ],
      "interventions": [
        {
          "name": "EO2002",
          "type": "BIOLOGICAL"
        },
        {
          "name": "EO2002 low dose",
          "type": "BIOLOGICAL"
        },
        {
          "name": "EO2002 mid dose",
          "type": "BIOLOGICAL"
        },
        {
          "name": "EO2002 high dose",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Emmecell",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 42,
      "start_date": "2021-06-22",
      "completion_date": "2024-10-03",
      "has_results": false,
      "last_update_posted_date": "2025-03-05",
      "last_synced_at": "2026-05-22T08:10:59.774Z",
      "location_count": 8,
      "location_summary": "Greater Los Angeles, California • San Diego, California • Miami, Florida + 5 more",
      "locations": [
        {
          "city": "Greater Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Palm Beach Gardens",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04894110"
    },
    {
      "nct_id": "NCT00744796",
      "title": "Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Corneal Edema Secondary to Corneal Endothelial Dystrophy"
      ],
      "interventions": [
        {
          "name": "DSAEK",
          "type": "PROCEDURE"
        },
        {
          "name": "Anterior Segment Optical Coherence Topography (OCT)",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Best Spectacle Corrected Visual Acuity (BSCVA)",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2006-12",
      "completion_date": "2009-07",
      "has_results": true,
      "last_update_posted_date": "2020-12-11",
      "last_synced_at": "2026-05-22T08:10:59.774Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00744796"
    },
    {
      "nct_id": "NCT04520321",
      "title": "A Phase 1/ Phase 2 Study of TTHX1114(NM141)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Corneal Endothelial Dystrophy",
        "Fuchs Endothelial Corneal Dystrophy",
        "Pseudophakic Bullous Keratopathy",
        "Endothelial Dysfunction"
      ],
      "interventions": [
        {
          "name": "TTHX1114(NM141)",
          "type": "DRUG"
        },
        {
          "name": "Vehicle (placebo)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Trefoil Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 22,
      "start_date": "2020-08-19",
      "completion_date": "2021-05-18",
      "has_results": true,
      "last_update_posted_date": "2023-10-30",
      "last_synced_at": "2026-05-22T08:10:59.774Z",
      "location_count": 8,
      "location_summary": "Petaluma, California • Jacksonville, Florida • Hoffman Estates, Illinois + 5 more",
      "locations": [
        {
          "city": "Petaluma",
          "state": "California"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Hoffman Estates",
          "state": "Illinois"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Kansas City",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04520321"
    },
    {
      "nct_id": "NCT07368959",
      "title": "AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Corneal Edema",
        "Corneal Endothelial Dysfunction",
        "Fuchs Endothelial Corneal Dysfunction",
        "Pseudophakic Bullous Keratopathy (PBK)"
      ],
      "interventions": [
        {
          "name": "Combination Product: AURN001 + Y-27632",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Aurion Biotech",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 120,
      "start_date": "2026-02-19",
      "completion_date": "2028-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-08",
      "last_synced_at": "2026-05-22T08:10:59.774Z",
      "location_count": 12,
      "location_summary": "Mesa, Arizona • Little Rock, Arkansas • Fort Collins, Colorado + 9 more",
      "locations": [
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Fort Collins",
          "state": "Colorado"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Kansas City",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07368959"
    }
  ]
}