{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Critical+Illness",
    "query": {
      "condition": "Critical Illness"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 587,
    "total_pages": 59,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Critical+Illness&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-21T22:55:32.909Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03717831",
      "title": "Muscle Dysfunction in Critical Illness",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Critical Illness",
        "Intensive Care (ICU) Myopathy",
        "PICS",
        "Muscle Weakness"
      ],
      "interventions": [
        {
          "name": "Observational study of standard of care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Kentucky",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 66,
      "start_date": "2018-10-17",
      "completion_date": "2019-07-15",
      "has_results": false,
      "last_update_posted_date": "2020-01-31",
      "last_synced_at": "2026-05-21T22:55:32.909Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03717831"
    },
    {
      "nct_id": "NCT00178581",
      "title": "Enteral Glutamine Supplementation for the Patient With Major Torso Trauma",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Trauma",
        "Critical Illness",
        "Shock"
      ],
      "interventions": [
        {
          "name": "Glutamine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2005-06",
      "completion_date": "2006-09",
      "has_results": false,
      "last_update_posted_date": "2010-04-23",
      "last_synced_at": "2026-05-21T22:55:32.909Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00178581"
    },
    {
      "nct_id": "NCT05541029",
      "title": "Music Listening: A Mechanistic Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Critical Illness"
      ],
      "interventions": [
        {
          "name": "Live music",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Recorded music",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Usual care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Months",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "2 Months to 17 Years"
      },
      "enrollment_count": 171,
      "start_date": "2023-03-20",
      "completion_date": "2027-05-03",
      "has_results": false,
      "last_update_posted_date": "2026-01-20",
      "last_synced_at": "2026-05-21T22:55:32.909Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05541029"
    },
    {
      "nct_id": "NCT03021902",
      "title": "Nutrition and Exercise in Critical Illness",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Acute Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "IV amino acids",
          "type": "DRUG"
        },
        {
          "name": "In-bed cycle ergometry exercise",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Clinical Evaluation Research Unit at Kingston General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 115,
      "start_date": "2017-09-28",
      "completion_date": "2025-06-23",
      "has_results": false,
      "last_update_posted_date": "2025-08-27",
      "last_synced_at": "2026-05-21T22:55:32.909Z",
      "location_count": 7,
      "location_summary": "Lexington, Kentucky • Baltimore, Maryland • The Bronx, New York + 4 more",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "The Bronx",
          "state": "New York"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03021902"
    },
    {
      "nct_id": "NCT03196960",
      "title": "Effects of Mobility Dose in Surgical Intensive Care Unit Patients",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sarcopenia",
        "Muscle Weakness",
        "Critical Illness"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2017-05-22",
      "completion_date": "2018-12",
      "has_results": false,
      "last_update_posted_date": "2018-09-06",
      "last_synced_at": "2026-05-21T22:55:32.909Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03196960"
    },
    {
      "nct_id": "NCT03019133",
      "title": "Trial to Evaluate the Effects of Sound Modulation on Critically Ill Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Critical Illness",
        "Physiological Stress",
        "Delirium",
        "Sleep Deprivation"
      ],
      "interventions": [
        {
          "name": "Sound reduction",
          "type": "DEVICE"
        },
        {
          "name": "Sound masking",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Brian Gehlbach",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 120,
      "start_date": "2016-12",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-04-06",
      "last_synced_at": "2026-05-21T22:55:32.909Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03019133"
    },
    {
      "nct_id": "NCT01726595",
      "title": "Ultrasound Measurement of Reactive Hyperemia in Critical Care",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Severe Sepsis",
        "Critical Illness"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Rochester",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 250,
      "start_date": "2013-01",
      "completion_date": "2019-12",
      "has_results": false,
      "last_update_posted_date": "2020-02-12",
      "last_synced_at": "2026-05-21T22:55:32.909Z",
      "location_count": 1,
      "location_summary": "Rochester, New York",
      "locations": [
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01726595"
    },
    {
      "nct_id": "NCT06039501",
      "title": "The Family Perspectives Project Pilot Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Failure",
        "Family Support",
        "Physician-Patient Relations",
        "Critical Illness"
      ],
      "interventions": [
        {
          "name": "Family Perspective Program",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Matthew Modes",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 70,
      "start_date": "2023-10-13",
      "completion_date": "2026-10",
      "has_results": false,
      "last_update_posted_date": "2025-06-15",
      "last_synced_at": "2026-05-21T22:55:32.909Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06039501"
    },
    {
      "nct_id": "NCT05287204",
      "title": "Critical Illness Myopathy and Trajectory of Recovery in AKI Requiring CRRT",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acute Kidney Injury",
        "Critical Illness Myopathy",
        "Dialysis; Complications"
      ],
      "interventions": [
        {
          "name": "Musculoskeletal ultrasound",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Assessments of muscle strength and physical function",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Metabolomics",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of Iowa",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 10,
      "start_date": "2021-11-29",
      "completion_date": "2024-12-30",
      "has_results": false,
      "last_update_posted_date": "2024-03-28",
      "last_synced_at": "2026-05-21T22:55:32.909Z",
      "location_count": 3,
      "location_summary": "Iowa City, Iowa • Lexington, Kentucky • Albuquerque, New Mexico",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05287204"
    },
    {
      "nct_id": "NCT01846884",
      "title": "Specimen Stability Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acute Kidney Injury"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Astute Medical, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 124,
      "start_date": "2012-11",
      "completion_date": "2013-05",
      "has_results": false,
      "last_update_posted_date": "2013-05-17",
      "last_synced_at": "2026-05-21T22:55:32.909Z",
      "location_count": 6,
      "location_summary": "La Mesa, California • Honolulu, Hawaii • Idaho Falls, Idaho + 3 more",
      "locations": [
        {
          "city": "La Mesa",
          "state": "California"
        },
        {
          "city": "Honolulu",
          "state": "Hawaii"
        },
        {
          "city": "Idaho Falls",
          "state": "Idaho"
        },
        {
          "city": "Las Vegas",
          "state": "Nevada"
        },
        {
          "city": "Port Jefferson",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01846884"
    }
  ]
}