{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Crosslinking",
    "query": {
      "condition": "Crosslinking"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 64,
    "total_pages": 7,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Crosslinking&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T06:12:13.417Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02187549",
      "title": "Safety and Effectiveness Study of a Non-Crosslinked HA Alkylamide HYADD(TM) 4 Hydrogel for Osteoarthritis of the Knee",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Knee Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "HYMOVIS",
          "type": "DEVICE"
        },
        {
          "name": "Placebo",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Fidia Farmaceutici s.p.a.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 332,
      "start_date": "2014-06",
      "completion_date": "2016-03",
      "has_results": false,
      "last_update_posted_date": "2015-10-05",
      "last_synced_at": "2026-07-22T06:12:13.417Z",
      "location_count": 21,
      "location_summary": "Birmingham, Alabama • Brimingham, Alabama • Phoenix, Arizona + 17 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Brimingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Carmichael",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02187549"
    },
    {
      "nct_id": "NCT07155057",
      "title": "Evaluating Crosslinked Hyaluronate Canalicular Gel for the Treatment of DED in Patients Undergoing Cataract Surgery",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dry Eye Disease (DED)"
      ],
      "interventions": [
        {
          "name": "Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vance Thompson Vision",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2025-09-03",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-09-29",
      "last_synced_at": "2026-07-22T06:12:13.417Z",
      "location_count": 1,
      "location_summary": "Sioux Falls, South Dakota",
      "locations": [
        {
          "city": "Sioux Falls",
          "state": "South Dakota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07155057"
    },
    {
      "nct_id": "NCT02531087",
      "title": "Urinary Biomarkers of OI Pathobiology",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Osteogenesis Imperfecta"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Baylor College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 25,
      "start_date": "2015-08-17",
      "completion_date": "2026-08-31",
      "has_results": false,
      "last_update_posted_date": "2025-12-01",
      "last_synced_at": "2026-07-22T06:12:13.417Z",
      "location_count": 6,
      "location_summary": "Los Angeles, California • Omaha, Nebraska • New York, New York + 3 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Omaha",
          "state": "Nebraska"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02531087"
    },
    {
      "nct_id": "NCT03922542",
      "title": "Comparison of Standard vs. Accelerated Corneal Crosslinking",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Keratoconus",
        "Ectasia Corneal"
      ],
      "interventions": [
        {
          "name": "Riboflavin 0.1%",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Price Vision Group",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "10 Years and older"
      },
      "enrollment_count": 510,
      "start_date": "2019-04-16",
      "completion_date": "2026-07-01",
      "has_results": false,
      "last_update_posted_date": "2025-07-31",
      "last_synced_at": "2026-07-22T06:12:13.417Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03922542"
    },
    {
      "nct_id": "NCT07135167",
      "title": "Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Down Syndrome (DS)",
        "Keratoconus",
        "Pellucid Marginal Degeneration",
        "Forme Fruste Keratoconus (FFK)"
      ],
      "interventions": [
        {
          "name": "Epi-ON corneal cross-linking (CXL)",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Woolfson Eye Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "8 Years and older"
      },
      "enrollment_count": 225,
      "start_date": "2025-08-01",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-02-02",
      "last_synced_at": "2026-07-22T06:12:13.417Z",
      "location_count": 12,
      "location_summary": "Atlanta, Georgia • Canton, Georgia • Cumming, Georgia + 8 more",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Canton",
          "state": "Georgia"
        },
        {
          "city": "Cumming",
          "state": "Georgia"
        },
        {
          "city": "Douglasville",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07135167"
    },
    {
      "nct_id": "NCT02508428",
      "title": "Marathon and Enduron Polyethylene at Long-Term Follow-up",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis",
        "Arthritis",
        "Joint Diseases",
        "Musculoskeletal Diseases",
        "Rheumatic Diseases"
      ],
      "interventions": [
        {
          "name": "Hip Replacement with crosslinked Marathon polyethylene",
          "type": "DEVICE"
        },
        {
          "name": "Hip Replacement with noncrosslinked Enduron polyethylene",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Anderson Orthopaedic Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 230,
      "start_date": "1999-01-06",
      "completion_date": "2017-06-22",
      "has_results": true,
      "last_update_posted_date": "2020-12-01",
      "last_synced_at": "2026-07-22T06:12:13.417Z",
      "location_count": 1,
      "location_summary": "Alexandria, Virginia",
      "locations": [
        {
          "city": "Alexandria",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02508428"
    },
    {
      "nct_id": "NCT02095730",
      "title": "Corneal Cross-Linking Comparing Variables",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Unstable Corneas"
      ],
      "interventions": [
        {
          "name": "Epithelium-On Riboflavin",
          "type": "DRUG"
        },
        {
          "name": "Epithelium-Off Riboflavin",
          "type": "DRUG"
        },
        {
          "name": "UV Light - Continuous Beam",
          "type": "DEVICE"
        },
        {
          "name": "UV Pulsed Beam",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Crowd Health Research, LTD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 500,
      "start_date": "2014-05",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2014-03-26",
      "last_synced_at": "2026-07-22T06:12:13.417Z",
      "location_count": 16,
      "location_summary": "Santa Rosa, California • Denver, Colorado • Jacksonville, Florida + 13 more",
      "locations": [
        {
          "city": "Santa Rosa",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Des Plaines",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02095730"
    },
    {
      "nct_id": "NCT07124910",
      "title": "Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Keratoconus",
        "Ectasia of Cornea",
        "Pellucid Marginal Corneal Degeneration",
        "Forme Fruste Keratoconus (FFK)"
      ],
      "interventions": [
        {
          "name": "Epi-ON corneal cross-linking",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Woolfson Eye Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "8 Years and older"
      },
      "enrollment_count": 485,
      "start_date": "2025-08-01",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-02-02",
      "last_synced_at": "2026-07-22T06:12:13.417Z",
      "location_count": 12,
      "location_summary": "Atlanta, Georgia • Canton, Georgia • Cumming, Georgia + 8 more",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Canton",
          "state": "Georgia"
        },
        {
          "city": "Cumming",
          "state": "Georgia"
        },
        {
          "city": "Douglasville",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07124910"
    },
    {
      "nct_id": "NCT01325298",
      "title": "UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Keratoconus",
        "Ectasia",
        "Corneal Ectasia"
      ],
      "interventions": [
        {
          "name": "UV-X Light",
          "type": "DEVICE"
        },
        {
          "name": "Riboflavin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Mercy Center for Corrective Eye Surgery",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "14 Years to 55 Years"
      },
      "enrollment_count": 250,
      "start_date": "2011-03",
      "completion_date": "2014-05",
      "has_results": false,
      "last_update_posted_date": "2011-03-29",
      "last_synced_at": "2026-07-22T06:12:13.417Z",
      "location_count": 1,
      "location_summary": "McHenry, Illinois",
      "locations": [
        {
          "city": "McHenry",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01325298"
    },
    {
      "nct_id": "NCT04439552",
      "title": "fMRI and IVCM Cornea Microscopy of CXL in Keratoconus",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pain, Postoperative",
        "Pain, Chronic",
        "Pain, Acute",
        "Surgical Injury",
        "Surgical Wound",
        "Cornea Injury",
        "Cornea",
        "Keratoconus"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "8 Years to 35 Years"
      },
      "enrollment_count": 60,
      "start_date": "2021-10-04",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2025-12-19",
      "last_synced_at": "2026-07-22T06:12:13.417Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04439552"
    }
  ]
}