{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Crosslinking&page=2",
    "query": {
      "condition": "Crosslinking",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Crosslinking&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T22:01:37.072Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05027295",
      "title": "Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Keratoconus",
        "Corneal Ectasia"
      ],
      "interventions": [
        {
          "name": "riboflavin ophthalmic solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cornea and Laser Eye Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 170,
      "start_date": "2021-07-30",
      "completion_date": "2025-07",
      "has_results": false,
      "last_update_posted_date": "2023-01-04",
      "last_synced_at": "2026-07-22T22:01:37.072Z",
      "location_count": 1,
      "location_summary": "Teaneck, New Jersey",
      "locations": [
        {
          "city": "Teaneck",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05027295"
    },
    {
      "nct_id": "NCT04168112",
      "title": "Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Keratoconus, Unstable",
        "Collagen Crosslinking",
        "Postoperative Pain"
      ],
      "interventions": [
        {
          "name": "Dextenza",
          "type": "DRUG"
        },
        {
          "name": "Prednisolone Acetate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sight Medical Doctors PLLC",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2020-02-12",
      "completion_date": "2023-04-05",
      "has_results": true,
      "last_update_posted_date": "2024-01-30",
      "last_synced_at": "2026-07-22T22:01:37.072Z",
      "location_count": 1,
      "location_summary": "Babylon, New York",
      "locations": [
        {
          "city": "Babylon",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04168112"
    },
    {
      "nct_id": "NCT01384773",
      "title": "Progressive Keratoconus or Ectasia Treatment Plan",
      "overall_status": "NO_LONGER_AVAILABLE",
      "study_type": "EXPANDED_ACCESS",
      "phases": [],
      "conditions": [
        "Keratoconus",
        "Ectasia"
      ],
      "interventions": [
        {
          "name": "Riboflavin Solution",
          "type": "OTHER"
        },
        {
          "name": "UV-X Illumination System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "Stephen Trokel",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": null,
      "start_date": null,
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2023-02-09",
      "last_synced_at": "2026-07-22T22:01:37.072Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01384773"
    },
    {
      "nct_id": "NCT02531087",
      "title": "Urinary Biomarkers of OI Pathobiology",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Osteogenesis Imperfecta"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Baylor College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 25,
      "start_date": "2015-08-17",
      "completion_date": "2026-08-31",
      "has_results": false,
      "last_update_posted_date": "2025-12-01",
      "last_synced_at": "2026-07-22T22:01:37.072Z",
      "location_count": 6,
      "location_summary": "Los Angeles, California • Omaha, Nebraska • New York, New York + 3 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Omaha",
          "state": "Nebraska"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02531087"
    },
    {
      "nct_id": "NCT03080077",
      "title": "Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Keratoconus",
        "Ectasia"
      ],
      "interventions": [
        {
          "name": "Ricrolin+",
          "type": "DRUG"
        },
        {
          "name": "Epi-Off",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "10 Years and older"
      },
      "enrollment_count": 8,
      "start_date": "2016-06",
      "completion_date": "2019-06",
      "has_results": false,
      "last_update_posted_date": "2018-06-07",
      "last_synced_at": "2026-07-22T22:01:37.072Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03080077"
    },
    {
      "nct_id": "NCT06944639",
      "title": "Comparative Study of Three Collagen Membranes: 1 Non-cross-linked and 2 Cross-linked",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bone Regeneration"
      ],
      "interventions": [
        {
          "name": "Membrane Jason MB GmbH Non-cross-linked (NCL)",
          "type": "DEVICE"
        },
        {
          "name": "Membrane BioMend Extend Glutaraldehyde cross-linked",
          "type": "DEVICE"
        },
        {
          "name": "Membrane OSSIX Agile Ribose cross-linked (RCL)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Andrea Ravida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2025-04-28",
      "completion_date": "2026-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-29",
      "last_synced_at": "2026-07-22T22:01:37.072Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06944639"
    },
    {
      "nct_id": "NCT03938883",
      "title": "Ocular Bandage Gel (OBG) Pivotal Trial in Patients Undergoing Photorefractive Keratectomy (\"PRK\")",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ophthalmology",
        "Photorefractive Keratectomy (\"PRK\")",
        "Laser Assisted Surgery",
        "Refractive Surgery"
      ],
      "interventions": [
        {
          "name": "Ocular Bandage Gel (OBG)",
          "type": "DEVICE"
        },
        {
          "name": "Bandage Contact Lens (BCL)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Eyegate Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "22 Years to 50 Years"
      },
      "enrollment_count": 250,
      "start_date": "2019-06-25",
      "completion_date": "2019-10-10",
      "has_results": false,
      "last_update_posted_date": "2019-12-13",
      "last_synced_at": "2026-07-22T22:01:37.072Z",
      "location_count": 1,
      "location_summary": "Sioux Falls, South Dakota",
      "locations": [
        {
          "city": "Sioux Falls",
          "state": "South Dakota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03938883"
    },
    {
      "nct_id": "NCT01944007",
      "title": "Evaluation of Cross-Linked Polyelectrolyte (CLP) in Healthy Volunteers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Basic Science: Safety, Tolerability, Efficacy of CLP"
      ],
      "interventions": [
        {
          "name": "Cross-Linked Polyelectrolyte (CLP)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sorbent Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 25,
      "start_date": "2007-12",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2013-09-17",
      "last_synced_at": "2026-07-22T22:01:37.072Z",
      "location_count": 1,
      "location_summary": "Kalamazoo, Michigan",
      "locations": [
        {
          "city": "Kalamazoo",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01944007"
    },
    {
      "nct_id": "NCT01484002",
      "title": "Analysis of Crosslinked and Conventional Polyethylene Explants",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Total hip arthroplasty",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Anderson Orthopaedic Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2011-12",
      "completion_date": "2017-12",
      "has_results": false,
      "last_update_posted_date": "2017-01-24",
      "last_synced_at": "2026-07-22T22:01:37.072Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts • Alexandria, Virginia",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Alexandria",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01484002"
    },
    {
      "nct_id": "NCT02178020",
      "title": "Outcome Study of Highly-cross Linked Polyethylene vs. Standard Polyethylene for Primary Posterior Stabilized (PS) Total Knee",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Arthroplasty, Replacement, Knee"
      ],
      "interventions": [
        {
          "name": "knee arthroplasty, standard polyethylene",
          "type": "DEVICE"
        },
        {
          "name": "knee arthroplasty, XLP polyethylene",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Chapel Hill Orthopedics Surgery & Sports Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 500,
      "start_date": "2009-07",
      "completion_date": "2019-07",
      "has_results": false,
      "last_update_posted_date": "2017-02-01",
      "last_synced_at": "2026-07-22T22:01:37.072Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02178020"
    }
  ]
}