{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Degenerative+Mitral+Valve+Disease",
    "query": {
      "condition": "Degenerative Mitral Valve Disease"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 19,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Degenerative+Mitral+Valve+Disease&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T10:05:44.428Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06465745",
      "title": "AltaValve Pivotal Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Regurgitation",
        "Mitral Insufficiency",
        "Mitral Valve Incompetence",
        "Mitral Valve Regurgitation",
        "Mitral Incompetence"
      ],
      "interventions": [
        {
          "name": "AltaValve System.",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "4C Medical Technologies, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 450,
      "start_date": "2024-09-03",
      "completion_date": "2031-09",
      "has_results": false,
      "last_update_posted_date": "2025-05-02",
      "last_synced_at": "2026-06-26T10:05:44.428Z",
      "location_count": 20,
      "location_summary": "Phoenix, Arizona • Tucson, Arizona • San Francisco, California + 16 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Thousand Oaks",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06465745"
    },
    {
      "nct_id": "NCT01931956",
      "title": "Real World Expanded Multicenter Study of the MitraClip® System (REALISM)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Valve Insufficiency",
        "Mitral Valve Regurgitation",
        "Mitral Valve Incompetence",
        "Mitral Regurgitation",
        "Mitral Insufficiency"
      ],
      "interventions": [
        {
          "name": "MitraClip® implant",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 965,
      "start_date": "2009-01-22",
      "completion_date": "2018-06",
      "has_results": true,
      "last_update_posted_date": "2018-12-04",
      "last_synced_at": "2026-06-26T10:05:44.428Z",
      "location_count": 38,
      "location_summary": "Los Angeles, California • Mountain View, California • Sacramento, California + 31 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Mountain View",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01931956"
    },
    {
      "nct_id": "NCT03706833",
      "title": "Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Degenerative Mitral Valve Disease",
        "Mitral Regurgitation",
        "Mitral Insufficiency",
        "Functional Mitral Regurgitation"
      ],
      "interventions": [
        {
          "name": "Edwards PASCAL System",
          "type": "DEVICE"
        },
        {
          "name": "Abbott Mitraclip System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Edwards Lifesciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1247,
      "start_date": "2018-11-30",
      "completion_date": "2031-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-04-09",
      "last_synced_at": "2026-06-26T10:05:44.428Z",
      "location_count": 68,
      "location_summary": "Phoenix, Arizona • Tucson, Arizona • La Jolla, California + 52 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03706833"
    },
    {
      "nct_id": "NCT01940120",
      "title": "EVEREST II Pivotal Study High Risk Registry (HRR)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Valve Insufficiency",
        "Mitral Valve Regurgitation",
        "Mitral Valve Incompetence",
        "Mitral Regurgitation",
        "Mitral Insufficiency"
      ],
      "interventions": [
        {
          "name": "Percutaneous mitral valve repair using MitraClip implant",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 78,
      "start_date": "2007-02",
      "completion_date": "2013-02",
      "has_results": true,
      "last_update_posted_date": "2018-11-07",
      "last_synced_at": "2026-06-26T10:05:44.428Z",
      "location_count": 2,
      "location_summary": "Evanston, Illinois • Indianapolis, Indiana",
      "locations": [
        {
          "city": "Evanston",
          "state": "Illinois"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01940120"
    },
    {
      "nct_id": "NCT03433274",
      "title": "Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Regurgitation",
        "Mitral Insufficiency",
        "Mitral Valve Insufficiency",
        "Cardiovascular Diseases",
        "Valve Disease, Heart",
        "Heart Valve Diseases",
        "Functional Mitral Regurgitation",
        "Degenerative Mitral Valve Disease"
      ],
      "interventions": [
        {
          "name": "Tendyne Mitral Valve System",
          "type": "DEVICE"
        },
        {
          "name": "MitraClip System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 103,
      "start_date": "2018-06-15",
      "completion_date": "2028-06",
      "has_results": true,
      "last_update_posted_date": "2026-06-17",
      "last_synced_at": "2026-06-26T10:05:44.428Z",
      "location_count": 73,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 60 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03433274"
    },
    {
      "nct_id": "NCT02276547",
      "title": "Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Valve Regurgitation"
      ],
      "interventions": [
        {
          "name": "Mitral valve replacement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Shockwave Medical, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 27,
      "start_date": "2014-12",
      "completion_date": "2025-08",
      "has_results": true,
      "last_update_posted_date": "2025-05-20",
      "last_synced_at": "2026-06-26T10:05:44.428Z",
      "location_count": 6,
      "location_summary": "Los Angeles, California • Chicago, Illinois • Detroit, Michigan + 3 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02276547"
    },
    {
      "nct_id": "NCT00209274",
      "title": "Pivotal Study of a Percutaneous Mitral Valve Repair System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Valve Insufficiency",
        "Mitral Valve Regurgitation",
        "Mitral Valve Incompetence",
        "Mitral Regurgitation",
        "Mitral Insufficiency"
      ],
      "interventions": [
        {
          "name": "Percutaneous mitral valve repair using MitraClip implant",
          "type": "DEVICE"
        },
        {
          "name": "Mitral valve repair or replacement surgery",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 279,
      "start_date": "2005-08",
      "completion_date": "2014-12",
      "has_results": true,
      "last_update_posted_date": "2018-11-07",
      "last_synced_at": "2026-06-26T10:05:44.428Z",
      "location_count": 1,
      "location_summary": "Evanston, Illinois",
      "locations": [
        {
          "city": "Evanston",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00209274"
    },
    {
      "nct_id": "NCT04919980",
      "title": "TVMR With the INNOVALVE System Trial - Early Feasibility Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Valve Regurgitation (Degenerative or Functional)"
      ],
      "interventions": [
        {
          "name": "INNOVALVE system",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Edwards Lifesciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 65,
      "start_date": "2022-09-01",
      "completion_date": "2031-07-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-28",
      "last_synced_at": "2026-06-26T10:05:44.428Z",
      "location_count": 20,
      "location_summary": "Los Angeles, California • Palo Alto, California • Naples, Florida + 14 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Naples",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04919980"
    },
    {
      "nct_id": "NCT02803957",
      "title": "Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Valve Insufficiency"
      ],
      "interventions": [
        {
          "name": "NeoChord DS1000",
          "type": "DEVICE"
        },
        {
          "name": "Surgical Mitral Valve Repair",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "NeoChord",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 585,
      "start_date": "2016-11-03",
      "completion_date": "2027-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-08",
      "last_synced_at": "2026-06-26T10:05:44.428Z",
      "location_count": 14,
      "location_summary": "Sacramento, California • Stanford, California • Washington D.C., District of Columbia + 10 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02803957"
    },
    {
      "nct_id": "NCT00209339",
      "title": "Feasibility Study of a Percutaneous Mitral Valve Repair System.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Mitral Valve Insufficiency",
        "Mitral Valve Regurgitation",
        "Mitral Valve Incompetence",
        "Mitral Regurgitation",
        "Mitral Insufficiency"
      ],
      "interventions": [
        {
          "name": "Percutaneous mitral valve repair (MitraClip Implant)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 55,
      "start_date": "2003-07",
      "completion_date": "2011-10",
      "has_results": true,
      "last_update_posted_date": "2018-11-07",
      "last_synced_at": "2026-06-26T10:05:44.428Z",
      "location_count": 1,
      "location_summary": "Evanston, Illinois",
      "locations": [
        {
          "city": "Evanston",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00209339"
    }
  ]
}