{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Depression+Disorders",
    "query": {
      "condition": "Depression Disorders"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 4320,
    "total_pages": 432,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Depression+Disorders&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T03:54:11.313Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05084924",
      "title": "Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Anhedonia"
      ],
      "interventions": [
        {
          "name": "Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 35,
      "start_date": "2021-11-02",
      "completion_date": "2023-07-31",
      "has_results": true,
      "last_update_posted_date": "2024-06-25",
      "last_synced_at": "2026-05-22T03:54:11.313Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05084924"
    },
    {
      "nct_id": "NCT03645096",
      "title": "Development of Pregnenolone as a Treatment for Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Pregnenolone 500 mg",
          "type": "DRUG"
        },
        {
          "name": "Pregnenolone 800 mg",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 65 Years · Female only"
      },
      "enrollment_count": 34,
      "start_date": "2019-09-01",
      "completion_date": "2022-05-31",
      "has_results": true,
      "last_update_posted_date": "2024-05-01",
      "last_synced_at": "2026-05-22T03:54:11.313Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03645096"
    },
    {
      "nct_id": "NCT05687162",
      "title": "SSIs for Mental Health and Loneliness",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Loneliness",
        "Mental Health Issue",
        "Distress, Emotional",
        "Depression",
        "Anxiety",
        "Stress"
      ],
      "interventions": [
        {
          "name": "Overcoming Loneliness three-week intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Overcoming Loneliness single-session intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Single-session \"Sharing Feelings\" program",
          "type": "BEHAVIORAL"
        },
        {
          "name": "The Blu Surfer program: a popular online content-based intervention for psychological distress",
          "type": "BEHAVIORAL"
        },
        {
          "name": "The Action Brings Change (ABC) Program (TEAM Lab version)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Online help-seeking as usual",
          "type": "BEHAVIORAL"
        },
        {
          "name": "The Lonely Blu Surfer program: a popular online content-based intervention for loneliness",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Overcoming loneliness SSI 8-minute version",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of California, Irvine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 4370,
      "start_date": "2022-12-04",
      "completion_date": "2023-09-06",
      "has_results": false,
      "last_update_posted_date": "2024-07-22",
      "last_synced_at": "2026-05-22T03:54:11.313Z",
      "location_count": 1,
      "location_summary": "Irvine, California",
      "locations": [
        {
          "city": "Irvine",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05687162"
    },
    {
      "nct_id": "NCT01797575",
      "title": "N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Bipolar Disorder"
      ],
      "interventions": [
        {
          "name": "Aspirin",
          "type": "DRUG"
        },
        {
          "name": "N-acetyl-cysteine (NAC)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Sugar Pill",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 38,
      "start_date": "2013-01",
      "completion_date": "2017-02-01",
      "has_results": true,
      "last_update_posted_date": "2018-04-30",
      "last_synced_at": "2026-05-22T03:54:11.313Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01797575"
    },
    {
      "nct_id": "NCT01564719",
      "title": "Study of a Holistic Health Program for United Methodist Clergy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Depression",
        "Diabetes",
        "Hypertension",
        "Hypercholesterolemia"
      ],
      "interventions": [
        {
          "name": "Holistic health",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Duke Clergy Health Initiative",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1114,
      "start_date": "2010-10",
      "completion_date": "2016-08",
      "has_results": false,
      "last_update_posted_date": "2020-09-30",
      "last_synced_at": "2026-05-22T03:54:11.313Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01564719"
    },
    {
      "nct_id": "NCT06843200",
      "title": "Conversations With Caregivers About Health and Appearance",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Disordered Eating Behaviors",
        "Depression",
        "Feeding Behaviors",
        "Parent-Child Relations"
      ],
      "interventions": [
        {
          "name": "Parent Group Discussion",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Oregon",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 240,
      "start_date": "2025-01-27",
      "completion_date": "2026-07-01",
      "has_results": false,
      "last_update_posted_date": "2025-02-24",
      "last_synced_at": "2026-05-22T03:54:11.313Z",
      "location_count": 1,
      "location_summary": "Eugene, Oregon",
      "locations": [
        {
          "city": "Eugene",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06843200"
    },
    {
      "nct_id": "NCT03992027",
      "title": "Preventing Depression and Anxiety: A Cystic Fibrosis-Specific Cognitive Behavioral Therapy Intervention",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Depression",
        "Anxiety"
      ],
      "interventions": [
        {
          "name": "CF-CBT: A Cognitive-Behavioral Skills-Based Program to Promote Emotional Well-Being for Adults wtih Cystic Fibrosis",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Waitlist Control",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2019-07-22",
      "completion_date": "2022-10-31",
      "has_results": false,
      "last_update_posted_date": "2023-07-25",
      "last_synced_at": "2026-05-22T03:54:11.313Z",
      "location_count": 4,
      "location_summary": "Palo Alto, California • Kansas City, Kansas • Boston, Massachusetts + 1 more",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Kansas City",
          "state": "Kansas"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Buffalo",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03992027"
    },
    {
      "nct_id": "NCT07499583",
      "title": "Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Treatment Resistant Depression",
        "Substance Use Disorders"
      ],
      "interventions": [
        {
          "name": "Psilocybin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 50,
      "start_date": "2026-08-01",
      "completion_date": "2031-02-28",
      "has_results": false,
      "last_update_posted_date": "2026-03-30",
      "last_synced_at": "2026-05-22T03:54:11.313Z",
      "location_count": 2,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07499583"
    },
    {
      "nct_id": "NCT00421954",
      "title": "Open-label Ziprasidone Study for Psychosis Treatment in Adolescents",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Schizophreniform Disorder",
        "Schizoaffective Disorder",
        "Psychosis",
        "Depressive Disorder, Major",
        "Bipolar Disorder"
      ],
      "interventions": [
        {
          "name": "Ziprasidone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "New York State Psychiatric Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "13 Years to 17 Years"
      },
      "enrollment_count": 8,
      "start_date": "2006-05",
      "completion_date": "2009-05",
      "has_results": true,
      "last_update_posted_date": "2017-01-13",
      "last_synced_at": "2026-05-22T03:54:11.313Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00421954"
    },
    {
      "nct_id": "NCT01211756",
      "title": "Oxytocin Add-on for Stable Depressed Patients",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Dysthymia Disorder"
      ],
      "interventions": [
        {
          "name": "Oxytocin",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "David Feifel",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1,
      "start_date": "2010-10",
      "completion_date": "2015-12",
      "has_results": true,
      "last_update_posted_date": "2019-09-25",
      "last_synced_at": "2026-05-22T03:54:11.313Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01211756"
    }
  ]
}