{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Developmental+Bone+Disease",
    "query": {
      "condition": "Developmental Bone Disease"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 590,
    "total_pages": 59,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Developmental+Bone+Disease&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T18:12:50.790Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00546598",
      "title": "Post-approval Study of the DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Non-inflammatory Joint Disease",
        "Osteoarthritis",
        "Avascular Necrosis",
        "Congenital Hip Dysplasia",
        "Post-traumatic Arthritis"
      ],
      "interventions": [
        {
          "name": "Total hip replacement/arthroplasty",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "DePuy Orthopaedics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 106,
      "start_date": "2006-01-01",
      "completion_date": "2014-04-01",
      "has_results": false,
      "last_update_posted_date": "2021-11-30",
      "last_synced_at": "2026-07-23T18:12:50.790Z",
      "location_count": 6,
      "location_summary": "Atlanta, Georgia • Springfield, Illinois • Cleveland, Ohio + 2 more",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Springfield",
          "state": "Illinois"
        },
        {
          "city": "Springfield",
          "state": "Illinois"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "Maumee",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00546598"
    },
    {
      "nct_id": "NCT04035811",
      "title": "Prospective Clinical Assessment Study in Children With Achondroplasia (ACH)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Achondroplasia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "QED Therapeutics, a BridgeBio company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Months",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "30 Months to 17 Years"
      },
      "enrollment_count": 271,
      "start_date": "2019-08-12",
      "completion_date": "2025-08-27",
      "has_results": false,
      "last_update_posted_date": "2026-04-03",
      "last_synced_at": "2026-07-23T18:12:50.790Z",
      "location_count": 8,
      "location_summary": "Oakland, California • Aurora, Colorado • Wilmington, Delaware + 5 more",
      "locations": [
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Wilmington",
          "state": "Delaware"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Columbia",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04035811"
    },
    {
      "nct_id": "NCT00684957",
      "title": "Differential Effects of rhGH vs. rhIGF-1 on Cardiovascular Risk Factors",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Growth Hormone Deficiency"
      ],
      "interventions": [
        {
          "name": "Recombinant Human Growth Hormone",
          "type": "DRUG"
        },
        {
          "name": "Recombinant Human IGF-1",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "65 Years",
        "sex": "MALE",
        "summary": "25 Years to 65 Years · Male only"
      },
      "enrollment_count": 5,
      "start_date": "2008-01",
      "completion_date": "2012-10",
      "has_results": true,
      "last_update_posted_date": "2024-07-17",
      "last_synced_at": "2026-07-23T18:12:50.790Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00684957"
    },
    {
      "nct_id": "NCT01775358",
      "title": "Phase 1 Safety Study of ALRN-5281 in Healthy Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Growth Hormone Deficiency"
      ],
      "interventions": [
        {
          "name": "ALRN-5281 0.015 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "ALRN-5281 0.05 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "ALRN-5281 0.15 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "Placebo 0.015 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "Placebo 0.05mg/kg",
          "type": "DRUG"
        },
        {
          "name": "Placebo 0.15mg/kg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Aileron Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "20 Years to 50 Years"
      },
      "enrollment_count": 33,
      "start_date": "2013-01",
      "completion_date": "2013-05",
      "has_results": false,
      "last_update_posted_date": "2013-05-30",
      "last_synced_at": "2026-07-23T18:12:50.790Z",
      "location_count": 1,
      "location_summary": "Overland Park, Kansas",
      "locations": [
        {
          "city": "Overland Park",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01775358"
    },
    {
      "nct_id": "NCT07721493",
      "title": "Evaluation of the Safety and Effectiveness of the CORUS™ Posterior Cervical Stabilization System 3D (PCSS 3D) for the Treatment of 2-level Cervical Degenerative Disease",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Degenerative Disc Disease(DDD)"
      ],
      "interventions": [
        {
          "name": "Circumferential Cervical Fusion (CCF)",
          "type": "DEVICE"
        },
        {
          "name": "Anterior Cervical Discectomy and Fusion",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "Providence Medical Technology, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 225,
      "start_date": "2026-06-30",
      "completion_date": "2029-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-07-23",
      "last_synced_at": "2026-07-23T18:12:50.790Z",
      "location_count": 1,
      "location_summary": "Paducah, Kentucky",
      "locations": [
        {
          "city": "Paducah",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07721493"
    },
    {
      "nct_id": "NCT06160752",
      "title": "Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Locally Advanced Cholangiocarcinoma",
        "Intrahepatic Cholangiocarcinoma",
        "Solid Tumor",
        "Metastatic Cholangiocarcinoma"
      ],
      "interventions": [
        {
          "name": "Phase 1 Part A - dose escalation TYRA-200 taken once daily by mouth in 28-day cycles",
          "type": "DRUG"
        },
        {
          "name": "Phase 1 Part B - dose expansion TYRA-200 taken once daily by mouth in 28-day cycles",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tyra Biosciences, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2023-11-22",
      "completion_date": "2027-09",
      "has_results": false,
      "last_update_posted_date": "2024-10-03",
      "last_synced_at": "2026-07-23T18:12:50.790Z",
      "location_count": 4,
      "location_summary": "San Francisco, California • Boston, Massachusetts • Columbus, Ohio + 1 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06160752"
    },
    {
      "nct_id": "NCT00002945",
      "title": "High Dose Chemotherapy, Peripheral Stem Cell Transplantation, and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Leukemia"
      ],
      "interventions": [
        {
          "name": "aldesleukin",
          "type": "BIOLOGICAL"
        },
        {
          "name": "filgrastim",
          "type": "BIOLOGICAL"
        },
        {
          "name": "cyclophosphamide",
          "type": "DRUG"
        },
        {
          "name": "cytarabine",
          "type": "DRUG"
        },
        {
          "name": "etoposide",
          "type": "DRUG"
        },
        {
          "name": "idarubicin",
          "type": "DRUG"
        },
        {
          "name": "melphalan",
          "type": "DRUG"
        },
        {
          "name": "peripheral blood stem cell transplantation",
          "type": "PROCEDURE"
        },
        {
          "name": "radiation therapy",
          "type": "RADIATION"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG",
        "PROCEDURE",
        "RADIATION"
      ],
      "sponsor": "Roswell Park Cancer Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "25 Years and older"
      },
      "enrollment_count": 61,
      "start_date": "1996-12",
      "completion_date": "2011-08",
      "has_results": false,
      "last_update_posted_date": "2012-04-13",
      "last_synced_at": "2026-07-23T18:12:50.790Z",
      "location_count": 1,
      "location_summary": "Buffalo, New York",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00002945"
    },
    {
      "nct_id": "NCT00297713",
      "title": "Study of an Extended-Release, Crystalline Formulation of Recombinant Human Growth Hormone (ALTU-238) in Growth Hormone Deficient Adults to Determine Pharmacokinetics, Pharmacodynamics, and Drug Safety",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Adult Growth Hormone Deficiency"
      ],
      "interventions": [
        {
          "name": "ALTU-238",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Altus Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 12,
      "start_date": "2005-07",
      "completion_date": "2006-06",
      "has_results": false,
      "last_update_posted_date": "2006-12-13",
      "last_synced_at": "2026-07-23T18:12:50.790Z",
      "location_count": 3,
      "location_summary": "Louisville, Kentucky • Galveston, Texas • San Antonio, Texas",
      "locations": [
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Galveston",
          "state": "Texas"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00297713"
    },
    {
      "nct_id": "NCT02196818",
      "title": "A Multi-centre, Prospective Surveillance to Assess Mid-term Performance of the Mpact Cup",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Osteoarthritis",
        "Arthritis",
        "Avascular Necrosis",
        "Fracture of the Femoral Neck or Head",
        "Congenital Hip Dysplasia"
      ],
      "interventions": [
        {
          "name": "Mpact Acetabular Shell",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medacta International SA",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 200,
      "start_date": "2013-03",
      "completion_date": "2022-04",
      "has_results": false,
      "last_update_posted_date": "2023-03-22",
      "last_synced_at": "2026-07-23T18:12:50.790Z",
      "location_count": 4,
      "location_summary": "Denver, Colorado • Boise, Idaho • Libertyville, Illinois + 1 more",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Boise",
          "state": "Idaho"
        },
        {
          "city": "Libertyville",
          "state": "Illinois"
        },
        {
          "city": "West Jordan",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02196818"
    },
    {
      "nct_id": "NCT04721769",
      "title": "Endoscopic Strip Craniectomy for Treatment of Sagittal Craniosynostosis",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Craniosynostosis, Sagittal"
      ],
      "interventions": [
        {
          "name": "Endoscopic strip craniectomy (with lateral osteotomies) with post-operative helmet therapy",
          "type": "PROCEDURE"
        },
        {
          "name": "Endoscopic strip craniectomy (without lateral osteotomies) with post-operative helmet therapy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Baylor College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Months",
        "sex": "ALL",
        "summary": "Up to 6 Months"
      },
      "enrollment_count": 6,
      "start_date": "2020-12-18",
      "completion_date": "2025-05-01",
      "has_results": false,
      "last_update_posted_date": "2025-09-19",
      "last_synced_at": "2026-07-23T18:12:50.790Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04721769"
    }
  ]
}