{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Developmental+Defect&page=119",
    "query": {
      "condition": "Developmental Defect",
      "page": 119
    },
    "page_size": 10
  },
  "pagination": {
    "page": 119,
    "page_size": 10,
    "total_count": 10825,
    "total_pages": 1083,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Developmental+Defect&page=120&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Developmental+Defect&page=118&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-11-07T20:12:46.999Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00040456",
      "title": "Oral Magnesium Pidolate, Hemoglobin SC Disease, MG Pidolate",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "HEMOGLOBIN SC DISEASE"
      ],
      "interventions": [
        {
          "name": "Mg Pidolate",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Baylor College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 12,
      "start_date": "2001-01",
      "completion_date": "2006-05",
      "has_results": false,
      "last_update_posted_date": "2012-11-19",
      "last_synced_at": "2026-11-07T20:12:46.999Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts • Houston, Texas",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00040456"
    },
    {
      "nct_id": "NCT03758651",
      "title": "Williams Syndrome Strength, Hormones, Activity & Adiposity, DNA Programming, Eating Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Williams Syndrome",
        "Lipedema"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 144,
      "start_date": "2018-10-01",
      "completion_date": "2023-09-14",
      "has_results": false,
      "last_update_posted_date": "2023-10-19",
      "last_synced_at": "2026-11-07T20:12:46.999Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03758651"
    },
    {
      "nct_id": "NCT03715972",
      "title": "Cerebrovascular Reserve and White Matter Disease in Patients with Chronic Anemia",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Thalassemia",
        "Sickle Cell Disease",
        "Healthy Controls"
      ],
      "interventions": [
        {
          "name": "Hydroxyurea",
          "type": "DRUG"
        },
        {
          "name": "Acetazolamide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Children's Hospital Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "7 Years and older"
      },
      "enrollment_count": 165,
      "start_date": "2018-07-15",
      "completion_date": "2022-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-10-30",
      "last_synced_at": "2026-11-07T20:12:46.999Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03715972"
    },
    {
      "nct_id": "NCT04395495",
      "title": "RASopathy Biorepository",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "RAS Mutation",
        "Neurofibromatosis 1",
        "Noonan Syndrome",
        "Noonan Syndrome With Multiple Lentigines",
        "Noonan Neurofibromatosis Syndrome",
        "Cardiofaciocutaneous Syndrome",
        "Costello Syndrome",
        "Legius Syndrome",
        "Smith-Kingsmore Syndrome",
        "MTOR Gene Mutation",
        "GATOR-1 Gene Mutation",
        "SYNGAP1-Related Intellectual Disability",
        "DLG4",
        "MAPK1 Gene Mutation"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Children's Hospital Medical Center, Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 1000,
      "start_date": "2017-06-27",
      "completion_date": "2065-12",
      "has_results": false,
      "last_update_posted_date": "2025-12-18",
      "last_synced_at": "2026-11-07T20:12:46.999Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04395495"
    },
    {
      "nct_id": "NCT02996162",
      "title": "Hypercapnia and Its Association With Long-term Respiratory Morbidities in Premature Infants With Chronic Lung Disease",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Bronchopulmonary Dysplasia"
      ],
      "interventions": [
        {
          "name": "Massimo Root Monitoring System",
          "type": "DEVICE"
        },
        {
          "name": "ISA-Infrared Sidestream Gas Analyzer",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Days",
        "maximum_age": "1 Year",
        "sex": "ALL",
        "summary": "3 Days to 1 Year"
      },
      "enrollment_count": 0,
      "start_date": "2020-12-01",
      "completion_date": "2021-05-06",
      "has_results": false,
      "last_update_posted_date": "2021-08-02",
      "last_synced_at": "2026-11-07T20:12:46.999Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02996162"
    },
    {
      "nct_id": "NCT01474746",
      "title": "Trial of Sertraline to Treat Children With Fragile X Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Fragile X Syndrome"
      ],
      "interventions": [
        {
          "name": "Sertraline",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Randi J. Hagerman, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "24 Months",
        "maximum_age": "68 Months",
        "sex": "ALL",
        "summary": "24 Months to 68 Months"
      },
      "enrollment_count": 57,
      "start_date": "2012-01",
      "completion_date": "2015-09",
      "has_results": true,
      "last_update_posted_date": "2017-09-25",
      "last_synced_at": "2026-11-07T20:12:46.999Z",
      "location_count": 1,
      "location_summary": "Sacramento, California",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01474746"
    },
    {
      "nct_id": "NCT04771741",
      "title": "Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Bunion of Unspecified Foot",
        "Bunionette of Unspecified Foot",
        "Hammertoe",
        "Ankle Fractures",
        "Achilles Tendon Surgery"
      ],
      "interventions": [
        {
          "name": "Acetominophen",
          "type": "DRUG"
        },
        {
          "name": "Toradol",
          "type": "DRUG"
        },
        {
          "name": "Meloxicam",
          "type": "DRUG"
        },
        {
          "name": "Cyclobenzaprine",
          "type": "DRUG"
        },
        {
          "name": "Lyrica",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Prisma Health-Midlands",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 72,
      "start_date": "2020-12-01",
      "completion_date": "2023-04-26",
      "has_results": false,
      "last_update_posted_date": "2023-04-27",
      "last_synced_at": "2026-11-07T20:12:46.999Z",
      "location_count": 1,
      "location_summary": "Columbia, South Carolina",
      "locations": [
        {
          "city": "Columbia",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04771741"
    },
    {
      "nct_id": "NCT00001966",
      "title": "Mind-Body Therapy for Pain in Ehlers-Danlos Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Ehlers-Danlos Syndrome",
        "Pain"
      ],
      "interventions": [
        {
          "name": "Mind-body therapy",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Human Genome Research Institute (NHGRI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 40,
      "start_date": "2000-01",
      "completion_date": "2001-01",
      "has_results": false,
      "last_update_posted_date": "2008-03-04",
      "last_synced_at": "2026-11-07T20:12:46.999Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00001966"
    },
    {
      "nct_id": "NCT01114737",
      "title": "Safety and Therapeutic Effects of Sapropterin Dihydrochloride on Neuropsychiatric Symptoms in Phenylketonuria (PKU) Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Phenylketonuria"
      ],
      "interventions": [
        {
          "name": "Sapropterin dihydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "BioMarin Pharmaceutical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "8 Years to 65 Years"
      },
      "enrollment_count": 206,
      "start_date": "2010-08",
      "completion_date": "2013-03",
      "has_results": true,
      "last_update_posted_date": "2016-02-01",
      "last_synced_at": "2026-11-07T20:12:46.999Z",
      "location_count": 26,
      "location_summary": "La Jolla, California • Los Angeles, California • Palo Alto, California + 23 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01114737"
    },
    {
      "nct_id": "NCT02775656",
      "title": "UCB Cimzia Pregnancy Follow-up Study",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Rheumatoid Arthritis (RA)",
        "Crohn's Disease (CD)",
        "Psoriatic Arthritis (PsA)",
        "Axial Spondyloarthritis and Ankylosing Spondylitis"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "UCB BIOSCIENCES, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 64 Years · Female only"
      },
      "enrollment_count": 1,
      "start_date": "2016-11",
      "completion_date": "2017-12",
      "has_results": false,
      "last_update_posted_date": "2021-04-22",
      "last_synced_at": "2026-11-07T20:12:46.999Z",
      "location_count": 1,
      "location_summary": "Wilmington, North Carolina",
      "locations": [
        {
          "city": "Wilmington",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02775656"
    }
  ]
}