{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Developmental+Defect&page=40", "query": { "condition": "Developmental Defect", "page": 40 }, "page_size": 10 }, "pagination": { "page": 40, "page_size": 10, "total_count": 10802, "total_pages": 1081, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Developmental+Defect&page=41&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Developmental+Defect&page=39&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-25T18:55:31.520Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00467935", "title": "Scotoma Reduction in AMD Patients Treated With Ranibizumab", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Macular Degeneration" ], "interventions": [ { "name": "intravitreal injection Lucentis (ranibizumab)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Retina Research Foundation", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "50 Years to 90 Years" }, "enrollment_count": 20, "start_date": "2007-03", "completion_date": "2007-11", "has_results": false, "last_update_posted_date": "2011-07-29", "last_synced_at": "2026-10-25T18:55:31.520Z", "location_count": 1, "location_summary": "Slingerlands, New York", "locations": [ { "city": "Slingerlands", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00467935" }, { "nct_id": "NCT03583697", "title": "A Clinical Trial to Evaluate the Safety and Efficacy of BMN 111 in Infants and Young Children With Achondroplasia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Achondroplasia" ], "interventions": [ { "name": "BMN 111", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "BioMarin Pharmaceutical", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "59 Months", "sex": "ALL", "summary": "Up to 59 Months" }, "enrollment_count": 75, "start_date": "2018-06-13", "completion_date": "2022-01-26", "has_results": true, "last_update_posted_date": "2024-06-13", "last_synced_at": "2026-10-25T18:55:31.520Z", "location_count": 9, "location_summary": "Oakland, California • Torrance, California • Wilmington, Delaware + 6 more", "locations": [ { "city": "Oakland", "state": "California" }, { "city": "Torrance", "state": "California" }, { "city": "Wilmington", "state": "Delaware" }, { "city": "Decatur", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT03583697" }, { "nct_id": "NCT04965597", "title": "Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Bone Marrow Failure Syndrome", "Congenital Amegakaryocytic Thrombocytopenia", "Diamond-Blackfan Anemia", "Hereditary Sideroblastic Anemia", "Paroxysmal Nocturnal Hemoglobinuria", "Shwachman-Diamond Syndrome", "Hematologic Neoplasm With Germline GATA2 Mutation", "Hematologic Neoplasm With Germline SAMD9 Mutation", "Hematologic Neoplasm With Germline SAMD9L Mutation" ], "interventions": [ { "name": "Treosulfan", "type": "DRUG" }, { "name": "Fludarabine Phosphate", "type": "DRUG" }, { "name": "Tacrolimus", "type": "DRUG" }, { "name": "Methotrexate", "type": "DRUG" }, { "name": "Lapine T-Lymphocyte Immune Globulin", "type": "BIOLOGICAL" }, { "name": "Peripheral Blood Stem Cell Transplantation", "type": "PROCEDURE" }, { "name": "Allogeneic Bone Marrow Transplantation", "type": "PROCEDURE" }, { "name": "Quality-of-Life Assessment", "type": "OTHER" }, { "name": "Echocardiography", "type": "PROCEDURE" }, { "name": "Multigated Acquisition Scan", "type": "PROCEDURE" }, { "name": "Bone Marrow Biopsy", "type": "PROCEDURE" }, { "name": "Bone Marrow Aspiration", "type": "PROCEDURE" }, { "name": "Biospecimen Collection", "type": "PROCEDURE" }, { "name": "X-Ray Imaging", "type": "PROCEDURE" }, { "name": "Computed Tomography", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "BIOLOGICAL", "PROCEDURE", "OTHER" ], "sponsor": "Fred Hutchinson Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Year", "maximum_age": "49 Years", "sex": "ALL", "summary": "1 Year to 49 Years" }, "enrollment_count": 40, "start_date": "2022-04-19", "completion_date": "2026-02-18", "has_results": false, "last_update_posted_date": "2026-03-09", "last_synced_at": "2026-10-25T18:55:31.520Z", "location_count": 24, "location_summary": "Los Angeles, California • San Diego, California • San Francisco, California + 20 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT04965597" }, { "nct_id": "NCT01335113", "title": "A Scan Ultrasonography in the Evaluation of Retinopathy of Prematurity", "overall_status": "TERMINATED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Retinopathy of Prematurity" ], "interventions": [], "intervention_types": [], "sponsor": "Stanford University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 1, "start_date": "2010-10", "completion_date": "2015-10-01", "has_results": false, "last_update_posted_date": "2020-07-09", "last_synced_at": "2026-10-25T18:55:31.520Z", "location_count": 1, "location_summary": "Miami, Florida", "locations": [ { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01335113" }, { "nct_id": "NCT03740282", "title": "Early Weight-Bearing After the Lapiplasty Procedure", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Hallux Valgus", "Bunion" ], "interventions": [ { "name": "Lapiplasty", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Treace Medical Concepts, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "14 Years", "maximum_age": "58 Years", "sex": "ALL", "summary": "14 Years to 58 Years" }, "enrollment_count": 183, "start_date": "2018-11-06", "completion_date": "2026-05-31", "has_results": false, "last_update_posted_date": "2026-04-06", "last_synced_at": "2026-10-25T18:55:31.520Z", "location_count": 7, "location_summary": "Greeley, Colorado • Ankeny, Iowa • Jefferson City, Missouri + 4 more", "locations": [ { "city": "Greeley", "state": "Colorado" }, { "city": "Ankeny", "state": "Iowa" }, { "city": "Jefferson City", "state": "Missouri" }, { "city": "Las Vegas", "state": "Nevada" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT03740282" }, { "nct_id": "NCT03293524", "title": "Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Leber Hereditary Optic Neuropathy" ], "interventions": [ { "name": "GS010", "type": "GENETIC" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "GENETIC", "DRUG" ], "sponsor": "GenSight Biologics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "15 Years", "maximum_age": null, "sex": "ALL", "summary": "15 Years and older" }, "enrollment_count": 98, "start_date": "2018-03-12", "completion_date": "2024-07-23", "has_results": true, "last_update_posted_date": "2026-04-16", "last_synced_at": "2026-10-25T18:55:31.520Z", "location_count": 7, "location_summary": "Pasadena, California • Aurora, Colorado • Atlanta, Georgia + 4 more", "locations": [ { "city": "Pasadena", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03293524" }, { "nct_id": "NCT00266513", "title": "Studies of Disorders in Antibody Production and Related Primary Immunodeficiency States", "overall_status": "TERMINATED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hyper-IgM Syndrome", "Ectodermal Dysplasia" ], "interventions": [], "intervention_types": [], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 119, "start_date": "2005-12-14", "completion_date": "2013-07-11", "has_results": false, "last_update_posted_date": "2017-10-06", "last_synced_at": "2026-10-25T18:55:31.520Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00266513" }, { "nct_id": "NCT00962260", "title": "Expanded Access Trial of Plant Expressed Recombinant Glucocerebrosidase (prGCD) in Patients With Gaucher Disease", "overall_status": "NO_LONGER_AVAILABLE", "study_type": "EXPANDED_ACCESS", "phases": [], "conditions": [ "Gaucher Disease" ], "interventions": [ { "name": "Plant cell expressed recombinant glucocerebrosidase (prGCD)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": null, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": null, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2018-09-07", "last_synced_at": "2026-10-25T18:55:31.520Z", "location_count": 14, "location_summary": "La Jolla, California • Aurora, Colorado • Coral Springs, Florida + 11 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Coral Springs", "state": "Florida" }, { "city": "Decatur", "state": "Georgia" }, { "city": "Skokie", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT00962260" }, { "nct_id": "NCT04527523", "title": "Descemet Membrane Endothelial Keratoplasty vs. Descemet's Stripping With Endothelial Keratoplasty vs. Descemet Stripping Only", "overall_status": "TERMINATED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Cystoid Macular Edema", "Fuchs Dystrophy" ], "interventions": [ { "name": "Optical Coherence Tomography", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "Wake Forest University Health Sciences", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 4, "start_date": "2020-11-21", "completion_date": "2022-08-24", "has_results": false, "last_update_posted_date": "2023-01-13", "last_synced_at": "2026-10-25T18:55:31.520Z", "location_count": 1, "location_summary": "Winston-Salem, North Carolina", "locations": [ { "city": "Winston-Salem", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT04527523" }, { "nct_id": "NCT01112059", "title": "Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult Cystic Fibrosis (CF) Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "Doxycycline", "type": "DRUG" }, { "name": "placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "University of Alabama at Birmingham", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 40, "start_date": "2008-11", "completion_date": "2012-11", "has_results": true, "last_update_posted_date": "2017-03-06", "last_synced_at": "2026-10-25T18:55:31.520Z", "location_count": 1, "location_summary": "Birmingham, Alabama", "locations": [ { "city": "Birmingham", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT01112059" } ] }