{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Developmental+and+Epileptic+Encephalopathy", "query": { "condition": "Developmental and Epileptic Encephalopathy" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 34, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Developmental+and+Epileptic+Encephalopathy&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-06-10T11:28:13.814Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04537832", "title": "Natural History Study of Infants and Children With Developmental and Epileptic Encephalopathies", "overall_status": "TERMINATED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Dravet Syndrome" ], "interventions": [ { "name": "No Intervention", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Encoded Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Months", "maximum_age": "60 Months", "sex": "ALL", "summary": "6 Months to 60 Months" }, "enrollment_count": 58, "start_date": "2021-01-18", "completion_date": "2023-03-31", "has_results": false, "last_update_posted_date": "2023-06-12", "last_synced_at": "2026-06-10T11:28:13.814Z", "location_count": 12, "location_summary": "Los Angeles, California • San Francisco, California • Aurora, Colorado + 9 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Miami", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04537832" }, { "nct_id": "NCT06983158", "title": "A Clinical Trial of CAP-002 Gene Therapy in Pediatric Patients With Syntaxin-Binding Protein 1 (STXBP1) Encephalopathy", "overall_status": "SUSPENDED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Developmental and Epileptic Encephalopathy" ], "interventions": [ { "name": "gene therapy", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Capsida Biotherapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Months", "maximum_age": "7 Years", "sex": "ALL", "summary": "18 Months to 7 Years" }, "enrollment_count": 12, "start_date": "2025-07-03", "completion_date": "2028-12-20", "has_results": false, "last_update_posted_date": "2025-10-01", "last_synced_at": "2026-06-10T11:28:13.814Z", "location_count": 4, "location_summary": "Aurora, Colorado • New York, New York • Philadelphia, Pennsylvania + 1 more", "locations": [ { "city": "Aurora", "state": "Colorado" }, { "city": "New York", "state": "New York" }, { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06983158" }, { "nct_id": "NCT03944447", "title": "Outcomes Mandate National Integration With Cannabis as Medicine", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Chronic Pain", "Chronic Pain Syndrome", "Chronic Pain Due to Injury", "Chronic Pain Due to Trauma", "Fibromyalgia", "Seizures", "Hepatitis C", "Cancer", "Crohn Disease", "HIV/AIDS", "Multiple Sclerosis", "Traumatic Brain Injury", "Sickle Cell Disease", "Post Traumatic Stress Disorder", "Tourette Syndrome", "Ulcerative Colitis", "Glaucoma", "Epilepsy", "Inflammatory Bowel Diseases", "Parkinson Disease", "Amyotrophic Lateral Sclerosis", "Chronic Traumatic Encephalopathy", "Anxiety", "Depression", "Insomnia", "Autism", "Opioid-use Disorder", "Bipolar Disorder", "Covid19", "SARS-CoV Infection", "COVID-19", "Corona Virus Infection", "Coronavirus" ], "interventions": [ { "name": "Cannabis, Medical", "type": "DRUG" }, { "name": "RYAH-Medtech Inhaler", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "OMNI Medical Services, LLC", "sponsor_class": "NETWORK", "healthy_volunteers": true, "eligibility": { "minimum_age": "7 Years", "maximum_age": null, "sex": "ALL", "summary": "7 Years and older" }, "enrollment_count": 200000, "start_date": "2018-12-01", "completion_date": "2025-12-31", "has_results": false, "last_update_posted_date": "2022-06-02", "last_synced_at": "2026-06-10T11:28:13.814Z", "location_count": 17, "location_summary": "Boca Raton, Florida • Bradenton, Florida • Fort Lauderdale, Florida + 13 more", "locations": [ { "city": "Boca Raton", "state": "Florida" }, { "city": "Bradenton", "state": "Florida" }, { "city": "Fort Lauderdale", "state": "Florida" }, { "city": "Fort Myers", "state": "Florida" }, { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03944447" }, { "nct_id": "NCT06700811", "title": "Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Developmental and Epileptic Encephalopathies", "Epileptic Spasms", "Genetic Epilepsy", "Neonatal and Infant Epilepsy" ], "interventions": [ { "name": "Ketogenic diet", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Heather Olson", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "0 Days", "maximum_age": "9 Months", "sex": "ALL", "summary": "0 Days to 9 Months" }, "enrollment_count": 10, "start_date": "2025-08-11", "completion_date": "2028-05", "has_results": false, "last_update_posted_date": "2026-02-02", "last_synced_at": "2026-06-10T11:28:13.814Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT06700811" }, { "nct_id": "NCT04337697", "title": "Neonatal Seizure Registry - Developmental Functional EValuation", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Neonatal Seizure", "Hypoxic-Ischemic Encephalopathy", "Stroke", "Intracranial Hemorrhages", "Epilepsy", "Cerebral Palsy", "Intellectual Disability" ], "interventions": [], "intervention_types": [], "sponsor": "University of California, San Francisco", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "8 Years", "sex": "ALL", "summary": "2 Years to 8 Years" }, "enrollment_count": 188, "start_date": "2020-03-15", "completion_date": "2025-03-01", "has_results": false, "last_update_posted_date": "2026-02-05", "last_synced_at": "2026-06-10T11:28:13.814Z", "location_count": 9, "location_summary": "San Francisco, California • Stanford, California • Washington D.C., District of Columbia + 5 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04337697" }, { "nct_id": "NCT05818553", "title": "A Clinical Trial of PRAX-562 in Subjects With Developmental and Epileptic Encephalopathies (DEE)", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "SCN2A Encephalopathy", "SCN8A Encephalopathy" ], "interventions": [ { "name": "PRAX-562", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Praxis Precision Medicines", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Year", "maximum_age": "18 Years", "sex": "ALL", "summary": "1 Year to 18 Years" }, "enrollment_count": 77, "start_date": "2023-08-02", "completion_date": "2027-03-01", "has_results": false, "last_update_posted_date": "2026-01-29", "last_synced_at": "2026-06-10T11:28:13.814Z", "location_count": 4, "location_summary": "Atlanta, Georgia • Chicago, Illinois • Minneapolis, Minnesota + 1 more", "locations": [ { "city": "Atlanta", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Minneapolis", "state": "Minnesota" }, { "city": "Hackensack", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT05818553" }, { "nct_id": "NCT03166215", "title": "Study of TAK-935 as an Adjunctive Therapy in Participants With Developmental and/or Epileptic Encephalopathies", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Developmental and/or Epileptic Encephalopathies" ], "interventions": [ { "name": "TAK-935", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 18, "start_date": "2017-08-17", "completion_date": "2018-09-19", "has_results": true, "last_update_posted_date": "2021-01-07", "last_synced_at": "2026-06-10T11:28:13.814Z", "location_count": 11, "location_summary": "Phoenix, Arizona • Port Charlotte, Florida • Tampa, Florida + 8 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Port Charlotte", "state": "Florida" }, { "city": "Tampa", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Lexington", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT03166215" }, { "nct_id": "NCT05226780", "title": "Extension Study to Evaluate How Safe and Tolerable NBI-921352 is as an Adjunctive Therapy for Participants With SCN8A-DEE", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "SCN8A Developmental and Epileptic Encephalopathy Syndrome" ], "interventions": [ { "name": "NBI-921352", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Neurocrine Biosciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "22 Years", "sex": "ALL", "summary": "2 Years to 22 Years" }, "enrollment_count": 8, "start_date": "2022-07-12", "completion_date": "2025-11-12", "has_results": false, "last_update_posted_date": "2026-05-27", "last_synced_at": "2026-06-10T11:28:13.814Z", "location_count": 4, "location_summary": "San Francisco, California • Washington D.C., District of Columbia • Rochester, New York + 1 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Rochester", "state": "New York" }, { "city": "Fort Worth", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05226780" }, { "nct_id": "NCT01238250", "title": "Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "16P11.2 Deletion Syndrome", "16p11.2 Duplications", "1Q21.1 Deletion", "1Q21.1 Microduplication Syndrome (Disorder)", "ACTL6B", "ADNP", "AHDC1", "ANK2", "ANKRD11", "ARID1B", "ASH1L", "BCL11A", "CHAMP1", "CHD2", "CHD8", "CSNK2A1", "CTBP1", "CTNNB1 Gene Mutation", "CUL3", "DDX3X", "DNMT3A", "DSCAM", "DYRK1A", "FOXP1", "GRIN2A", "GRIN2B", "HIVEP2-Related Intellectual Disability", "HNRNPH2", "KATNAL2", "KDM5B", "KDM6B", "KMT2C Gene Mutation", "KMT2E", "KMT5B", "MBD5", "MED13L", "PACS1", "PPP2R5D-Related Intellectual Disability", "PTCHD1", "REST", "SCN2A Encephalopathy", "SETBP1 Gene Mutation", "SETD5", "SMARCA4 Gene Mutation", "SMARCC2", "STXBP1 Encephalopathy With Epilepsy", "SYNGAP1-Related Intellectual Disability", "TBR1", "ARHGEF9", "HNRNPU", "PPP3CA", "PPP2R1A", "SLC6A1", "2p16.3 Deletions", "5q35 Deletions", "5q35 Duplications", "7q11.23 Duplications", "15Q13.3 Deletion Syndrome", "16p11.2 Triplications", "16P12.2 Microdeletion", "16P13.11 Microdeletion Syndrome (Disorder)", "17Q12 Microdeletion Syndrome (Disorder)", "17Q12 Duplication Syndrome", "17Q21.31 Deletion Syndrome", "17q21.3 Duplications", "ACTB", "ADSL", "AFF2", "ALDH5A1", "ANK3", "ARX", "ATRX Gene Mutation", "AUTS2 Syndrome", "BCKDK", "BRSK2", "CACNA1C", "CAPRIN1", "CASK", "CASZ1", "CHD3", "CIC", "CNOT3", "CREBBP Gene Mutation", "CSDE1", "CTCF", "DEAF1", "DHCR7", "DLG4", "EBF3", "EHMT1", "EP300 Gene Mutation", "GIGYF1", "GRIN1", "GRIN2D", "IQSEC2-Related Syndromic Intellectual Disability", "IRF2BPL", "KANSL1", "KCNB1", "KDM3B", "NEXMIF", "KMT2A", "MBOAT7", "MEIS2", "MYT1L", "NAA15", "NBEA", "NCKAP1", "NIPBL", "NLGN2", "NLGN3", "NLGN4X", "NR4A2", "NRXN1", "NRXN2", "NSD1 Gene Mutation", "PHF21A", "PHF3", "PHIP", "POMGNT1", "PSMD12", "RELN", "RERE", "RFX3", "RIMS1", "RORB", "SCN1A", "SETD2 Gene Mutation", "SHANK2", "SIN3A", "SLC9A6", "SON", "SOX5", "SPAST", "SRCAP", "TAOK1", "TANC2", "TCF20", "TLK2", "TRIO", "TRIP12", "UPF3B", "USP9X", "VPS13B", "WAC", "WDFY3", "ZBTB20", "ZNF292", "ZNF462", "2Q37 Deletion Syndrome", "9q34 Duplications", "15q15 Deletions", "15Q24 Deletion", "NR3C2", "SYNCRIP", "2q34 Duplication", "2q37.3 Deletion", "6q16 Deletion", "15q11.2 BP1-BP2 Deletion", "16p13.3 Deletion", "17Q11.2 Microduplication Syndrome (Disorder)", "17p13.3", "Xq28 Duplication", "CLCN4", "CSNK2B", "DYNC1H1", "EIF3F", "GNB1", "MED13", "MEF2C", "RALGAPB", "SCN1B", "YY1", "Xp11.22 Duplication", "PACS2", "MAOA", "MAOB", "HNRNPC", "HNRNPD", "HNRNPK", "HNRNPR", "HNRNPUL2", "5P Deletion Syndrome", "TCF7L2 Gene Mutation", "HECW2" ], "interventions": [], "intervention_types": [], "sponsor": "Simons Searchlight", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 100000, "start_date": "2010-10", "completion_date": "2050-10", "has_results": false, "last_update_posted_date": "2025-06-06", "last_synced_at": "2026-06-10T11:28:13.814Z", "location_count": 2, "location_summary": "Boston, Massachusetts • Lewisburg, Pennsylvania", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "Lewisburg", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01238250" }, { "nct_id": "NCT06149663", "title": "Intermediate-Size Expanded Access Protocol (EAP) for LP352", "overall_status": "AVAILABLE", "study_type": "EXPANDED_ACCESS", "phases": [], "conditions": [ "Dravet Syndrome", "Lennox Gastaut Syndrome", "Developmental and Epileptic Encephalopathies" ], "interventions": [ { "name": "LP352", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Longboard Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": null, "eligibility": { "minimum_age": "2 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "2 Years to 65 Years" }, "enrollment_count": null, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2025-01-22", "last_synced_at": "2026-06-10T11:28:13.814Z", "location_count": 19, "location_summary": "Downey, California • Los Angeles, California • San Francisco, California + 15 more", "locations": [ { "city": "Downey", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Gulf Breeze", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06149663" } ] }