{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Diseases+of+the+Circulatory+System&page=42",
    "query": {
      "condition": "Diseases of the Circulatory System",
      "page": 42
    },
    "page_size": 10
  },
  "pagination": {
    "page": 42,
    "page_size": 10,
    "total_count": 3305,
    "total_pages": 331,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Diseases+of+the+Circulatory+System&page=43&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Diseases+of+the+Circulatory+System&page=41&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-16T15:22:01.767Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01576523",
      "title": "A Study to Evaluate the Clinical Pharmacology and Safety of C1-esterase Inhibitor Administered by the Subcutaneous Route",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Hereditary Angioedema Types I and II"
      ],
      "interventions": [
        {
          "name": "C1-esterase inhibitor - single intravenous dose",
          "type": "BIOLOGICAL"
        },
        {
          "name": "C1-esterase inhibitor - subcutaneous low dose",
          "type": "BIOLOGICAL"
        },
        {
          "name": "C1-esterase inhibitor - subcutaneous medium dose",
          "type": "BIOLOGICAL"
        },
        {
          "name": "C1-esterase inhibitor - subcutaneous high dose",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "CSL Behring",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2012-04",
      "completion_date": "2012-12",
      "has_results": true,
      "last_update_posted_date": "2021-02-01",
      "last_synced_at": "2026-10-16T15:22:01.767Z",
      "location_count": 5,
      "location_summary": "Atlanta, Georgia • Chevy Chase, Maryland • Cincinnati, Ohio + 2 more",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Chevy Chase",
          "state": "Maryland"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Toledo",
          "state": "Ohio"
        },
        {
          "city": "Hershey",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01576523"
    },
    {
      "nct_id": "NCT06029959",
      "title": "Stroke and CPAP Outcome Study 3",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ischemic Stroke",
        "Intra Cerebral Hemorrhage",
        "Obstructive Sleep Apnea",
        "Adherence, Treatment",
        "Motivation"
      ],
      "interventions": [
        {
          "name": "Continuous positive airway pressure (CPAP)",
          "type": "DEVICE"
        },
        {
          "name": "CPAP technical support intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Motivational Enhancement Therapy (MET)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Mobile Health intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 36,
      "start_date": "2023-10-01",
      "completion_date": "2025-01-01",
      "has_results": true,
      "last_update_posted_date": "2025-10-08",
      "last_synced_at": "2026-10-16T15:22:01.767Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06029959"
    },
    {
      "nct_id": "NCT01580813",
      "title": "Evaluating the Effects of a Study Medication on Exercise Function in Type 2 Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 2 Diabetes"
      ],
      "interventions": [
        {
          "name": "Acipimox",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "30 Years to 60 Years"
      },
      "enrollment_count": 13,
      "start_date": "2011-06",
      "completion_date": "2015-06-05",
      "has_results": true,
      "last_update_posted_date": "2021-12-03",
      "last_synced_at": "2026-10-16T15:22:01.767Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01580813"
    },
    {
      "nct_id": "NCT00489580",
      "title": "A Pilot Study Investigating the Feasibility of the Saebo Arm Training Program on an Inpatient Population",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stroke",
        "Hemiplegia"
      ],
      "interventions": [
        {
          "name": "SaeboFlex Dynamic Hand Orthosis",
          "type": "DEVICE"
        },
        {
          "name": "Saebo F.T.M. Arm Training Program",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "Kessler Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2005-08",
      "completion_date": "2006-05",
      "has_results": false,
      "last_update_posted_date": "2007-07-25",
      "last_synced_at": "2026-10-16T15:22:01.767Z",
      "location_count": 1,
      "location_summary": "East Orange, New Jersey",
      "locations": [
        {
          "city": "East Orange",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00489580"
    },
    {
      "nct_id": "NCT05256303",
      "title": "Rural Hospital-Level Care at Home for Acutely Ill Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Infections",
        "Heart Failure",
        "Chronic Obstructive Pulmonary Disease",
        "Asthma",
        "Gout Flare",
        "Chronic Kidney Diseases",
        "Hypertensive Urgency",
        "Atrial Fibrillation Rapid",
        "Anticoagulation",
        "Diabetes and Its Complications",
        "End of Life/Desires Only Medical Management"
      ],
      "interventions": [
        {
          "name": "Home Hospital care",
          "type": "OTHER"
        },
        {
          "name": "Traditional Hospital care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 160,
      "start_date": "2022-02-16",
      "completion_date": "2024-01-17",
      "has_results": false,
      "last_update_posted_date": "2025-11-12",
      "last_synced_at": "2026-10-16T15:22:01.767Z",
      "location_count": 2,
      "location_summary": "Quincy, Illinois • Hazard, Kentucky",
      "locations": [
        {
          "city": "Quincy",
          "state": "Illinois"
        },
        {
          "city": "Hazard",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05256303"
    },
    {
      "nct_id": "NCT00538850",
      "title": "Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Cancer"
      ],
      "interventions": [
        {
          "name": "Fentanyl sublingual spray",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "INSYS Therapeutics Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 130,
      "start_date": "2007-10",
      "completion_date": "2010-10",
      "has_results": true,
      "last_update_posted_date": "2014-03-05",
      "last_synced_at": "2026-10-16T15:22:01.767Z",
      "location_count": 1,
      "location_summary": "Chandler, Arizona",
      "locations": [
        {
          "city": "Chandler",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00538850"
    },
    {
      "nct_id": "NCT01901874",
      "title": "The Gore SCAFFOLD Clinical Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Carotid Artery Disease",
        "Carotid Artery Stenosis"
      ],
      "interventions": [
        {
          "name": "Carotid Artery Stenting",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "W.L.Gore & Associates",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 312,
      "start_date": "2013-07",
      "completion_date": "2020-09",
      "has_results": true,
      "last_update_posted_date": "2020-10-29",
      "last_synced_at": "2026-10-16T15:22:01.767Z",
      "location_count": 2,
      "location_summary": "Honolulu, Hawaii • Wynnewood, Pennsylvania",
      "locations": [
        {
          "city": "Honolulu",
          "state": "Hawaii"
        },
        {
          "city": "Wynnewood",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01901874"
    },
    {
      "nct_id": "NCT04893590",
      "title": "Adapting MHealth Technology to Improve Patient Activation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injuries",
        "Stroke",
        "Multiple Sclerosis"
      ],
      "interventions": [
        {
          "name": "Fatigue self-management SMS intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 27,
      "start_date": "2021-05-14",
      "completion_date": "2022-02-28",
      "has_results": false,
      "last_update_posted_date": "2025-03-28",
      "last_synced_at": "2026-10-16T15:22:01.767Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04893590"
    },
    {
      "nct_id": "NCT06487780",
      "title": "Evaluating a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetic Foot",
        "Diabetic Foot Ulcer",
        "Foot Ulcer, Diabetic",
        "Foot Wound"
      ],
      "interventions": [
        {
          "name": "Lifestyle-focused Occupational Therapy Intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Education",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2025-06-11",
      "completion_date": "2026-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-06-22",
      "last_synced_at": "2026-10-16T15:22:01.767Z",
      "location_count": 3,
      "location_summary": "Downey, California • Los Angeles, California",
      "locations": [
        {
          "city": "Downey",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06487780"
    },
    {
      "nct_id": "NCT07646782",
      "title": "Human Observatory Study",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Aging",
        "Mortality",
        "All-cause Mortality",
        "Life Expectancy",
        "Cardiovascular Diseases",
        "Neoplasms",
        "Cognitive Dysfunction",
        "Metabolic Syndrome",
        "Frailty",
        "Musculoskeletal Disease",
        "Neurodegenerative Disease",
        "Dementia",
        "Activities of Daily Living",
        "Health Related Quality of Life",
        "Environmental Exposure",
        "Occupational Diseases",
        "Health Equity",
        "Social Determinants of Health",
        "Physical Disability"
      ],
      "interventions": [
        {
          "name": "Multi-Domain Ecological and Clinical Data Linkage",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Longevity Metrics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1000000,
      "start_date": "2026-04-25",
      "completion_date": "2099-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-09-08",
      "last_synced_at": "2026-10-16T15:22:01.767Z",
      "location_count": 1,
      "location_summary": "Boulder, Colorado",
      "locations": [
        {
          "city": "Boulder",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07646782"
    }
  ]
}