{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Down+Syndrome&page=2",
    "query": {
      "condition": "Down Syndrome",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Down+Syndrome&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T01:40:47.784Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01821300",
      "title": "Down Syndrome Metabolic Health Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome",
        "Trisomy 21"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "10 Years to 20 Years"
      },
      "enrollment_count": 257,
      "start_date": "2013-02",
      "completion_date": "2017-08-25",
      "has_results": true,
      "last_update_posted_date": "2019-07-31",
      "last_synced_at": "2026-05-22T01:40:47.784Z",
      "location_count": 2,
      "location_summary": "Washington D.C., District of Columbia • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01821300"
    },
    {
      "nct_id": "NCT00891852",
      "title": "Non-Invasive Determination of Fetal Chromosome Abnormalities",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome (Trisomy 21)",
        "Edward's Syndrome (Trisomy 18)",
        "Patau Syndrome (Trisomy 13)",
        "Klinefelter Syndrome (47, XXY)",
        "and Other Chromosome",
        "Abnormalities."
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Lenetix Medical Screening Laboratory",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 1000,
      "start_date": "2009-01",
      "completion_date": "2009-12",
      "has_results": false,
      "last_update_posted_date": "2009-05-01",
      "last_synced_at": "2026-05-22T01:40:47.784Z",
      "location_count": 7,
      "location_summary": "Rockville, Maryland • Moristown, New Jersey • Mineola, New York + 3 more",
      "locations": [
        {
          "city": "Rockville",
          "state": "Maryland"
        },
        {
          "city": "Moristown",
          "state": "New Jersey"
        },
        {
          "city": "Mineola",
          "state": "New York"
        },
        {
          "city": "New Hyde Park",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00891852"
    },
    {
      "nct_id": "NCT02521493",
      "title": "Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Acute Myeloid Leukemia",
        "Down Syndrome",
        "Myelodysplastic Syndrome",
        "Myeloid Leukemia Associated With Down Syndrome",
        "Myeloproliferative Neoplasm"
      ],
      "interventions": [
        {
          "name": "Asparaginase",
          "type": "DRUG"
        },
        {
          "name": "Asparaginase Erwinia chrysanthemi",
          "type": "DRUG"
        },
        {
          "name": "Cytarabine",
          "type": "DRUG"
        },
        {
          "name": "Daunorubicin Hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Etoposide",
          "type": "DRUG"
        },
        {
          "name": "Laboratory Biomarker Analysis",
          "type": "OTHER"
        },
        {
          "name": "Mitoxantrone Hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Thioguanine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Children's Oncology Group",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "91 Days",
        "maximum_age": "3 Years",
        "sex": "ALL",
        "summary": "91 Days to 3 Years"
      },
      "enrollment_count": 280,
      "start_date": "2015-12-23",
      "completion_date": "2026-06-30",
      "has_results": true,
      "last_update_posted_date": "2025-08-01",
      "last_synced_at": "2026-05-22T01:40:47.784Z",
      "location_count": 169,
      "location_summary": "Birmingham, Alabama • Anchorage, Alaska • Mesa, Arizona + 131 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Anchorage",
          "state": "Alaska"
        },
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02521493"
    },
    {
      "nct_id": "NCT01256112",
      "title": "Parent Supported Weight Reduction in Down Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Down Syndrome"
      ],
      "interventions": [
        {
          "name": "Parent Supported Behavioral Intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Nutrition/Activity Education (NAE)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "26 Years",
        "sex": "ALL",
        "summary": "13 Years to 26 Years"
      },
      "enrollment_count": 21,
      "start_date": "2006-09",
      "completion_date": "2010-03",
      "has_results": false,
      "last_update_posted_date": "2017-10-18",
      "last_synced_at": "2026-05-22T01:40:47.784Z",
      "location_count": 1,
      "location_summary": "Waltham, Massachusetts",
      "locations": [
        {
          "city": "Waltham",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01256112"
    },
    {
      "nct_id": "NCT03684512",
      "title": "Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Adolescent Behavior",
        "Intellectual Disability",
        "Down Syndrome",
        "Physical Activity"
      ],
      "interventions": [
        {
          "name": "Group Exercise Sessions",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Individual Support Sessions",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Facebook Group",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Kansas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "21 Years",
        "sex": "ALL",
        "summary": "10 Years to 21 Years"
      },
      "enrollment_count": 116,
      "start_date": "2019-01-07",
      "completion_date": "2022-10-28",
      "has_results": true,
      "last_update_posted_date": "2023-07-03",
      "last_synced_at": "2026-05-22T01:40:47.784Z",
      "location_count": 1,
      "location_summary": "Lawrence, Kansas",
      "locations": [
        {
          "city": "Lawrence",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03684512"
    },
    {
      "nct_id": "NCT05343468",
      "title": "Life Skills Improved in Children With Down Syndrome After Using Assistive Technology",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Down Syndrome",
        "Adaptive Behavior",
        "Quality of Life"
      ],
      "interventions": [
        {
          "name": "The MapHabit System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "MapHabit, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "7 Years to 17 Years"
      },
      "enrollment_count": 26,
      "start_date": "2020-09-20",
      "completion_date": "2021-08-05",
      "has_results": false,
      "last_update_posted_date": "2023-02-24",
      "last_synced_at": "2026-05-22T01:40:47.784Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05343468"
    },
    {
      "nct_id": "NCT05196984",
      "title": "Gamma Frequency Stimulation in Individuals With Down Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Down Syndrome"
      ],
      "interventions": [
        {
          "name": "GENUS device (Active Settings)",
          "type": "DEVICE"
        },
        {
          "name": "GENUS device (Sham Settings)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts Institute of Technology",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "25 Years to 65 Years"
      },
      "enrollment_count": 60,
      "start_date": "2021-12-06",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-31",
      "last_synced_at": "2026-05-22T01:40:47.784Z",
      "location_count": 1,
      "location_summary": "Cambridge, Massachusetts",
      "locations": [
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05196984"
    },
    {
      "nct_id": "NCT05198232",
      "title": "The Effects of Virtual Zumba® in Individuals With Developmental Disabilities",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Developmental Disability",
        "Autism Spectrum Disorder",
        "Down Syndrome",
        "Cerebral Palsy"
      ],
      "interventions": [
        {
          "name": "Zumba High Tempo",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Zumba Low Tempo",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Auburn University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 57,
      "start_date": "2021-01-26",
      "completion_date": "2022-03-30",
      "has_results": false,
      "last_update_posted_date": "2022-05-05",
      "last_synced_at": "2026-05-22T01:40:47.784Z",
      "location_count": 1,
      "location_summary": "Auburn, Alabama",
      "locations": [
        {
          "city": "Auburn",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05198232"
    },
    {
      "nct_id": "NCT03653143",
      "title": "JASPER Intervention in Down Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Down Syndrome, Trisomy 21"
      ],
      "interventions": [
        {
          "name": "JASPER",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "24 Months",
        "maximum_age": "48 Months",
        "sex": "ALL",
        "summary": "24 Months to 48 Months"
      },
      "enrollment_count": 12,
      "start_date": "2018-12-01",
      "completion_date": "2021-07-31",
      "has_results": false,
      "last_update_posted_date": "2022-01-18",
      "last_synced_at": "2026-05-22T01:40:47.784Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03653143"
    },
    {
      "nct_id": "NCT06614582",
      "title": "Long-term Evaluation of Nasopharyngeal Airway in Hypotonia",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypotonia, Muscle",
        "Obstructive Sleep Apnea",
        "Nasal Airway Obstruction"
      ],
      "interventions": [
        {
          "name": "Self-Supporting Nasopharyngeal Airway (ssNPA)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "23 Years",
        "sex": "ALL",
        "summary": "3 Years to 23 Years"
      },
      "enrollment_count": 40,
      "start_date": "2024-10-23",
      "completion_date": "2026-10",
      "has_results": false,
      "last_update_posted_date": "2025-12-02",
      "last_synced_at": "2026-05-22T01:40:47.784Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06614582"
    }
  ]
}