{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Down+Syndrome+%28Trisomy+21%29&page=2",
    "query": {
      "condition": "Down Syndrome (Trisomy 21)",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Down+Syndrome+%28Trisomy+21%29&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-11T02:29:23.459Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00754013",
      "title": "Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Down Syndrome",
        "Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "Aricept (Donepezil hydrochloride)",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eisai Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "10 Years",
        "sex": "ALL",
        "summary": "6 Years to 10 Years"
      },
      "enrollment_count": 9,
      "start_date": "2008-09",
      "completion_date": "2008-12",
      "has_results": true,
      "last_update_posted_date": "2020-01-28",
      "last_synced_at": "2026-06-11T02:29:23.459Z",
      "location_count": 2,
      "location_summary": "San Antonio, Texas • Herndon, Virginia",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        },
        {
          "city": "Herndon",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00754013"
    },
    {
      "nct_id": "NCT02317965",
      "title": "Non-Invasive Screening for Fetal Aneuploidy",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome",
        "Edwards Syndrome"
      ],
      "interventions": [
        {
          "name": "Maternal Blood Draw",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Progenity, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "54 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 54 Years · Female only"
      },
      "enrollment_count": 340,
      "start_date": "2015-03",
      "completion_date": "2018-11",
      "has_results": false,
      "last_update_posted_date": "2018-08-28",
      "last_synced_at": "2026-06-11T02:29:23.459Z",
      "location_count": 10,
      "location_summary": "Campbell, California • Long Beach, California • Denver, Colorado + 6 more",
      "locations": [
        {
          "city": "Campbell",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Englewood",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02317965"
    },
    {
      "nct_id": "NCT01920633",
      "title": "A Screening Protocol to Assess Adults and Adolescents With Down Syndrome for Eligibility For Upcoming Study of RG1662 (Study BP27832)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Hoffmann-La Roche",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "12 Years to 30 Years"
      },
      "enrollment_count": 135,
      "start_date": "2013-10-31",
      "completion_date": "2015-01-31",
      "has_results": false,
      "last_update_posted_date": "2017-07-19",
      "last_synced_at": "2026-06-11T02:29:23.459Z",
      "location_count": 9,
      "location_summary": "La Jolla, California • Decatur, Georgia • Chicago, Illinois + 6 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Decatur",
          "state": "Georgia"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01920633"
    },
    {
      "nct_id": "NCT06673069",
      "title": "Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Alzheimer Disease",
        "Down Syndrome"
      ],
      "interventions": [
        {
          "name": "ION269",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Ionis Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "35 Years to 55 Years"
      },
      "enrollment_count": 1,
      "start_date": "2024-12-20",
      "completion_date": "2025-12-03",
      "has_results": false,
      "last_update_posted_date": "2026-02-20",
      "last_synced_at": "2026-06-11T02:29:23.459Z",
      "location_count": 5,
      "location_summary": "Indianapolis, Indiana • Kansas City, Kansas • Lexington, Kentucky + 2 more",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Kansas City",
          "state": "Kansas"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06673069"
    },
    {
      "nct_id": "NCT06450509",
      "title": "Proactive Speech and Language Intervention for Infants With Down Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Down Syndrome"
      ],
      "interventions": [
        {
          "name": "Babble Boot Camp",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Arizona State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Months",
        "maximum_age": "12 Months",
        "sex": "ALL",
        "summary": "0 Months to 12 Months"
      },
      "enrollment_count": 60,
      "start_date": "2024-02-28",
      "completion_date": "2026-03-30",
      "has_results": false,
      "last_update_posted_date": "2026-04-29",
      "last_synced_at": "2026-06-11T02:29:23.459Z",
      "location_count": 1,
      "location_summary": "Tempe, Arizona",
      "locations": [
        {
          "city": "Tempe",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06450509"
    },
    {
      "nct_id": "NCT02381457",
      "title": "SNP-based Microdeletion and Aneuploidy RegisTry (SMART)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "22q11 Deletion Syndrome",
        "DiGeorge Syndrome",
        "Trisomy 21",
        "Trisomy 18",
        "Trisomy 13",
        "Monosomy X",
        "Sex Chromosome Abnormalities",
        "Cri-du-Chat Syndrome",
        "Angelman Syndrome",
        "Prader-Willi Syndrome",
        "1p36 Deletion Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Natera, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "48 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 48 Years · Female only"
      },
      "enrollment_count": 20960,
      "start_date": "2015-04",
      "completion_date": "2020-06",
      "has_results": false,
      "last_update_posted_date": "2021-01-29",
      "last_synced_at": "2026-06-11T02:29:23.459Z",
      "location_count": 16,
      "location_summary": "San Francisco, California • Camden, New Jersey • Mount Laurel, New Jersey + 10 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Camden",
          "state": "New Jersey"
        },
        {
          "city": "Mount Laurel",
          "state": "New Jersey"
        },
        {
          "city": "New Brunswick",
          "state": "New Jersey"
        },
        {
          "city": "Garden City",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02381457"
    },
    {
      "nct_id": "NCT07630207",
      "title": "Vascular Function in Adults With Down Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome (Trisomy 21)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Nevada, Las Vegas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 24,
      "start_date": "2026-04-09",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-05",
      "last_synced_at": "2026-06-11T02:29:23.459Z",
      "location_count": 1,
      "location_summary": "Las Vegas, Nevada",
      "locations": [
        {
          "city": "Las Vegas",
          "state": "Nevada"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07630207"
    },
    {
      "nct_id": "NCT07425769",
      "title": "Adapting RDAD for DS",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Down Syndrome (DS)",
        "Alzheimer's Disease (AD)"
      ],
      "interventions": [
        {
          "name": "Remote Exercise Sessions",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Caregiver Education Sessions",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Kansas Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 40,
      "start_date": "2026-03-31",
      "completion_date": "2026-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-06",
      "last_synced_at": "2026-06-11T02:29:23.459Z",
      "location_count": 1,
      "location_summary": "Kansas City, Kansas",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07425769"
    },
    {
      "nct_id": "NCT04124471",
      "title": "Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Down Syndrome",
        "Obstructive Sleep Apnea"
      ],
      "interventions": [
        {
          "name": "Open-ended semi-structured interviews",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "6 Years to 17 Years"
      },
      "enrollment_count": 42,
      "start_date": "2019-08-02",
      "completion_date": "2022-08-01",
      "has_results": true,
      "last_update_posted_date": "2023-04-25",
      "last_synced_at": "2026-06-11T02:29:23.459Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04124471"
    },
    {
      "nct_id": "NCT01808508",
      "title": "Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Down Syndrome",
        "Obstructive Sleep Apnea Syndrome"
      ],
      "interventions": [
        {
          "name": "Continuous positive airway pressure",
          "type": "DEVICE"
        },
        {
          "name": "Sham or placebo continuous positive airway pressure",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "8 Years to 20 Years"
      },
      "enrollment_count": 27,
      "start_date": "2010-09",
      "completion_date": "2014-09",
      "has_results": true,
      "last_update_posted_date": "2016-02-08",
      "last_synced_at": "2026-06-11T02:29:23.459Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01808508"
    }
  ]
}