{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Driver+Mutation", "query": { "condition": "Driver Mutation" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 27, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Driver+Mutation&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-17T17:55:31.849Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03101839", "title": "Phase I Dose-Escalation Study of AZD4785 in Patients With Advanced Solid Tumours", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Non-Small Cell Lung Cancer", "Advanced Solid Tumours" ], "interventions": [ { "name": "AZD4785", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "130 Years", "sex": "ALL", "summary": "18 Years to 130 Years" }, "enrollment_count": 28, "start_date": "2017-05-15", "completion_date": "2019-01-08", "has_results": false, "last_update_posted_date": "2019-10-04", "last_synced_at": "2026-09-17T17:55:31.849Z", "location_count": 3, "location_summary": "Sarasota, Florida • Boston, Massachusetts • Nashville, Tennessee", "locations": [ { "city": "Sarasota", "state": "Florida" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT03101839" }, { "nct_id": "NCT03140670", "title": "Maintenance Rucaparib in BRCA1, BRCA2 or PALB2 Mutated Pancreatic Cancer That Has Not Progressed on Platinum-based Therapy", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Pancreatic Cancer" ], "interventions": [ { "name": "RUCAPARIB", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Abramson Cancer Center at Penn Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 46, "start_date": "2017-09-05", "completion_date": "2023-08-07", "has_results": true, "last_update_posted_date": "2023-09-28", "last_synced_at": "2026-09-17T17:55:31.849Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT03140670" }, { "nct_id": "NCT04584255", "title": "Niraparib + Dostarlimab In BRCA Mutated Breast Cancer", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Stage I Breast Cancer", "Stage II Breast Cancer", "Stage III Breast Cancer", "Breast Cancer", "HER2-negative Breast Cancer", "Germline BRCA1 Gene Mutation", "Germline BRCA2 Gene Mutation", "Deleterious PALB2 Gene Mutation" ], "interventions": [ { "name": "Niraparib", "type": "DRUG" }, { "name": "Dostarlimab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Dana-Farber Cancer Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 62, "start_date": "2020-12-18", "completion_date": "2029-07-17", "has_results": false, "last_update_posted_date": "2026-05-13", "last_synced_at": "2026-09-17T17:55:31.849Z", "location_count": 8, "location_summary": "New Haven, Connecticut • Baltimore, Maryland • Boston, Massachusetts + 3 more", "locations": [ { "city": "New Haven", "state": "Connecticut" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04584255" }, { "nct_id": "NCT04171700", "title": "A Study to Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Solid Tumor" ], "interventions": [ { "name": "Rucaparib", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "pharmaand GmbH", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 83, "start_date": "2020-01-16", "completion_date": "2022-07-15", "has_results": true, "last_update_posted_date": "2023-10-02", "last_synced_at": "2026-09-17T17:55:31.849Z", "location_count": 19, "location_summary": "Los Angeles, California • San Francisco, California • Fort Myers, Florida + 15 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Fort Myers", "state": "Florida" }, { "city": "St. Petersburg", "state": "Florida" }, { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04171700" }, { "nct_id": "NCT04257045", "title": "Factors Influencing Cascade Testing Among Women With Hereditary Gynecological Cancers and Their Relatives", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Breast Carcinoma", "Deleterious CDH1 Gene Mutation", "Deleterious DICER1 Gene Mutation", "Deleterious SMARCA4 Gene Mutation", "Deleterious STK11 Gene Mutation", "Endometrial Carcinoma", "Fallopian Tube Carcinoma", "Ovarian Carcinoma", "Primary Peritoneal Carcinoma" ], "interventions": [ { "name": "Interview", "type": "OTHER" }, { "name": "Questionnaire Administration", "type": "OTHER" }, { "name": "Survey Administration", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "M.D. Anderson Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 46, "start_date": "2019-08-21", "completion_date": "2024-07-09", "has_results": false, "last_update_posted_date": "2024-07-12", "last_synced_at": "2026-09-17T17:55:31.849Z", "location_count": 2, "location_summary": "Birmingham, Alabama • Houston, Texas", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04257045" }, { "nct_id": "NCT04640259", "title": "Epidemiology of Young Lung Cancer - Survey", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "NSCLC" ], "interventions": [ { "name": "Online Survey", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Addario Lung Cancer Medical Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 187, "start_date": "2021-02-01", "completion_date": "2026-03-06", "has_results": false, "last_update_posted_date": "2026-08-04", "last_synced_at": "2026-09-17T17:55:31.849Z", "location_count": 2, "location_summary": "Los Angeles, California • San Carlos, California", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "San Carlos", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04640259" }, { "nct_id": "NCT02949843", "title": "Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "EGFR Activating Mutation", "Recurrent Non-Small Cell Lung Carcinoma", "Stage IV Non-Small Cell Lung Cancer" ], "interventions": [ { "name": "Chemotherapy", "type": "DRUG" }, { "name": "Immunotherapy", "type": "BIOLOGICAL" }, { "name": "Laboratory Biomarker Analysis", "type": "OTHER" }, { "name": "Nivolumab", "type": "BIOLOGICAL" }, { "name": "Pembrolizumab", "type": "BIOLOGICAL" }, { "name": "Targeted Molecular Therapy", "type": "DRUG" }, { "name": "Tyrosine Kinase Inhibitor", "type": "DRUG" } ], "intervention_types": [ "DRUG", "BIOLOGICAL", "OTHER" ], "sponsor": "Wake Forest University Health Sciences", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 19, "start_date": "2017-03-10", "completion_date": "2021-01-12", "has_results": true, "last_update_posted_date": "2024-06-28", "last_synced_at": "2026-09-17T17:55:31.849Z", "location_count": 1, "location_summary": "Winston-Salem, North Carolina", "locations": [ { "city": "Winston-Salem", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT02949843" }, { "nct_id": "NCT03609216", "title": "Gemcitabine and Cisplatin Without Cystectomy for Patients With Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Infiltrating Bladder Urothelial Carcinoma", "Stage II Bladder Urothelial Carcinoma", "Stage III Bladder Urothelial Carcinoma" ], "interventions": [ { "name": "Gemcitabine Hydrochloride", "type": "DRUG" }, { "name": "Cisplatin", "type": "DRUG" }, { "name": "Pegfilgrastim", "type": "BIOLOGICAL" }, { "name": "Conventional Surgery", "type": "PROCEDURE" }, { "name": "Radical Cystectomy", "type": "PROCEDURE" }, { "name": "Chemoradiotherapy", "type": "OTHER" } ], "intervention_types": [ "DRUG", "BIOLOGICAL", "PROCEDURE", "OTHER" ], "sponsor": "Alliance for Clinical Trials in Oncology", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 237, "start_date": "2018-12-10", "completion_date": "2029-02-01", "has_results": false, "last_update_posted_date": "2026-04-13", "last_synced_at": "2026-09-17T17:55:31.849Z", "location_count": 424, "location_summary": "Fairbanks, Alaska • Goodyear, Arizona • Phoenix, Arizona + 293 more", "locations": [ { "city": "Fairbanks", "state": "Alaska" }, { "city": "Goodyear", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Fort Smith", "state": "Arkansas" }, { "city": "Hot Springs", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03609216" }, { "nct_id": "NCT02760849", "title": "Surgery in Preventing Ovarian Cancer in Patients With Genetic Mutations", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Deleterious BARD1 Gene Mutation", "Deleterious BRCA1 Gene Mutation", "Deleterious BRCA2 Gene Mutation", "Deleterious BRIP1 Gene Mutation", "Deleterious EPCAM Gene Mutation", "Deleterious MLH1 Gene Mutation", "Deleterious MSH2 Gene Mutation", "Deleterious MSH6 Gene Mutation", "Deleterious PALB2 Gene Mutation", "Deleterious PMS2 Gene Mutation", "Deleterious RAD51C Gene Mutation", "Deleterious RAD51D Gene Mutation", "Hereditary Breast and Ovarian Cancer Syndrome", "Premenopausal" ], "interventions": [ { "name": "Laboratory Biomarker Analysis", "type": "OTHER" }, { "name": "Oophorectomy", "type": "PROCEDURE" }, { "name": "Quality-of-Life Assessment", "type": "OTHER" }, { "name": "Salpingectomy", "type": "PROCEDURE" }, { "name": "Salpingo-Oophorectomy", "type": "PROCEDURE" } ], "intervention_types": [ "OTHER", "PROCEDURE" ], "sponsor": "M.D. Anderson Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "30 Years to 50 Years · Female only" }, "enrollment_count": 374, "start_date": "2016-05-02", "completion_date": "2041-05-31", "has_results": false, "last_update_posted_date": "2026-07-15", "last_synced_at": "2026-09-17T17:55:31.849Z", "location_count": 9, "location_summary": "Chicago, Illinois • Boston, Massachusetts • Rochester, Minnesota + 5 more", "locations": [ { "city": "Chicago", "state": "Illinois" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Rochester", "state": "Minnesota" }, { "city": "St Louis", "state": "Missouri" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02760849" }, { "nct_id": "NCT05697198", "title": "PRospective REgistry of Advanced Stage CancER (PREFER) Patients to Assess Prevalence of Actionable Biomarkers and Driver Mutations to Address Disparities in Precision Medicine", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Lung Cancer", "Ovarian Cancer", "Uterine Cancer", "Colorectal Cancer", "Stomach Cancer", "Esophageal Cancer", "Pancreatic Cancer", "Melanoma", "Breast Cancer", "Head and Neck Cancer", "Soft Tissue Sarcoma", "Rhabdomyosarcoma", "Prostate Cancer" ], "interventions": [ { "name": "OmniSeq Test", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "Labcorp Corporation of America Holdings, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1429, "start_date": "2021-04-19", "completion_date": "2024-12-31", "has_results": false, "last_update_posted_date": "2025-03-06", "last_synced_at": "2026-09-17T17:55:31.849Z", "location_count": 8, "location_summary": "Fort Payne, Alabama • Orange City, Florida • Stuart, Florida + 5 more", "locations": [ { "city": "Fort Payne", "state": "Alabama" }, { "city": "Orange City", "state": "Florida" }, { "city": "Stuart", "state": "Florida" }, { "city": "Dublin", "state": "Georgia" }, { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT05697198" } ] }