{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Early+Stages+of+Cognitive+Decline",
    "query": {
      "condition": "Early Stages of Cognitive Decline"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 12,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Early+Stages+of+Cognitive+Decline&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T18:13:46.216Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03919162",
      "title": "A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Alzheimer Disease"
      ],
      "interventions": [
        {
          "name": "PQ912",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Vivoryon Therapeutics N.V.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "50 Years to 89 Years"
      },
      "enrollment_count": 112,
      "start_date": "2021-11-15",
      "completion_date": "2024-08-12",
      "has_results": true,
      "last_update_posted_date": "2025-12-12",
      "last_synced_at": "2026-07-23T18:13:46.216Z",
      "location_count": 22,
      "location_summary": "Phoenix, Arizona • Sun City, Arizona • Chula Vista, California + 19 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Sun City",
          "state": "Arizona"
        },
        {
          "city": "Chula Vista",
          "state": "California"
        },
        {
          "city": "Irvine",
          "state": "California"
        },
        {
          "city": "La Jolla",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03919162"
    },
    {
      "nct_id": "NCT05077826",
      "title": "Enhancing Memory in Mild Cognitive Impairment and Early Stage Alzheimer's Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alzheimer Disease",
        "Mild Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "North Coast Medical Activadose II",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The Mind Research Network",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "50 Years to 90 Years"
      },
      "enrollment_count": 98,
      "start_date": "2021-10-07",
      "completion_date": "2023-04-30",
      "has_results": false,
      "last_update_posted_date": "2024-03-13",
      "last_synced_at": "2026-07-23T18:13:46.216Z",
      "location_count": 1,
      "location_summary": "Albuquerque, New Mexico",
      "locations": [
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05077826"
    },
    {
      "nct_id": "NCT04928976",
      "title": "Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alzheimer Disease",
        "Preclinical Alzheimer's Disease",
        "Prodromal Alzheimer's Disease",
        "Alzheimer's Disease (Incl Subtypes)",
        "Mild Cognitive Impairment"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Novoic Limited",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "50 Years to 85 Years"
      },
      "enrollment_count": 67,
      "start_date": "2021-01-22",
      "completion_date": "2021-07-30",
      "has_results": false,
      "last_update_posted_date": "2021-09-05",
      "last_synced_at": "2026-07-23T18:13:46.216Z",
      "location_count": 1,
      "location_summary": "Santa Ana, California",
      "locations": [
        {
          "city": "Santa Ana",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04928976"
    },
    {
      "nct_id": "NCT00909662",
      "title": "Fatigue Caused by Chemotherapy in Women Who Have Undergone Surgery for Breast Cancer and in Healthy Volunteers",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Breast Cancer",
        "Cognitive/Functional Effects",
        "Fatigue",
        "Long-term Effects Secondary to Cancer Therapy in Adults"
      ],
      "interventions": [
        {
          "name": "assessment of therapy complications",
          "type": "PROCEDURE"
        },
        {
          "name": "cognitive assessment",
          "type": "PROCEDURE"
        },
        {
          "name": "fatigue assessment and management",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Case Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 18,
      "start_date": "2008-07",
      "completion_date": "2010-12",
      "has_results": false,
      "last_update_posted_date": "2015-10-02",
      "last_synced_at": "2026-07-23T18:13:46.216Z",
      "location_count": 2,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00909662"
    },
    {
      "nct_id": "NCT02951598",
      "title": "A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alzheimer Disease",
        "Mild Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "Florbetapir F 18 PET Scan",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eli Lilly and Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "55 Years to 85 Years"
      },
      "enrollment_count": 1400,
      "start_date": "2016-10-29",
      "completion_date": "2026-04-28",
      "has_results": false,
      "last_update_posted_date": "2025-10-24",
      "last_synced_at": "2026-07-23T18:13:46.216Z",
      "location_count": 77,
      "location_summary": "Anaheim, California • Imperial, California • Irvine, California + 59 more",
      "locations": [
        {
          "city": "Anaheim",
          "state": "California"
        },
        {
          "city": "Anaheim",
          "state": "California"
        },
        {
          "city": "Imperial",
          "state": "California"
        },
        {
          "city": "Irvine",
          "state": "California"
        },
        {
          "city": "Irvine",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02951598"
    },
    {
      "nct_id": "NCT05187117",
      "title": "CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dementia, Mild",
        "Mild Cognitive Impairment",
        "Disability Physical",
        "Impairment, Cognitive",
        "Caregiver Burden",
        "Quality of Life",
        "Depression"
      ],
      "interventions": [
        {
          "name": "CAPABLE Family - Open Label Pilot",
          "type": "BEHAVIORAL"
        },
        {
          "name": "CAPABLE Family - Randomized Control Trial",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 74,
      "start_date": "2022-03-09",
      "completion_date": "2024-04-15",
      "has_results": false,
      "last_update_posted_date": "2024-04-17",
      "last_synced_at": "2026-07-23T18:13:46.216Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05187117"
    },
    {
      "nct_id": "NCT05894954",
      "title": "Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Mild Cognitive Impairment",
        "Dementia, Mild"
      ],
      "interventions": [
        {
          "name": "Precision Medicine Approach",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Hormones and Medications tailored to lab tests, combined with devices that support stress management and brain exercises",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Standard-of-Care",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Lifestyle including diet, exercise, stress management",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "COMBINATION_PRODUCT",
        "BEHAVIORAL"
      ],
      "sponsor": "Alzheimer's Prevention and Reversal Project, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "76 Years",
        "sex": "ALL",
        "summary": "45 Years to 76 Years"
      },
      "enrollment_count": 73,
      "start_date": "2023-07-31",
      "completion_date": "2026-02-09",
      "has_results": false,
      "last_update_posted_date": "2026-02-18",
      "last_synced_at": "2026-07-23T18:13:46.216Z",
      "location_count": 6,
      "location_summary": "Folsom, California • San Rafael, California • Walnut Creek, California + 3 more",
      "locations": [
        {
          "city": "Folsom",
          "state": "California"
        },
        {
          "city": "San Rafael",
          "state": "California"
        },
        {
          "city": "Walnut Creek",
          "state": "California"
        },
        {
          "city": "Hollywood",
          "state": "Florida"
        },
        {
          "city": "Rocky River",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05894954"
    },
    {
      "nct_id": "NCT04937959",
      "title": "Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - PAST Extension",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alzheimer Disease",
        "Alzheimer's Disease (Incl Subtypes)",
        "Preclinical Alzheimer's Disease",
        "Prodromal Alzheimer's Disease",
        "Mild Cognitive Impairment",
        "Normal Cognition"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Novoic Limited",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "50 Years to 85 Years"
      },
      "enrollment_count": 40,
      "start_date": "2021-01-22",
      "completion_date": "2022-08-30",
      "has_results": false,
      "last_update_posted_date": "2022-04-07",
      "last_synced_at": "2026-07-23T18:13:46.216Z",
      "location_count": 1,
      "location_summary": "Santa Ana, California",
      "locations": [
        {
          "city": "Santa Ana",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04937959"
    },
    {
      "nct_id": "NCT07214974",
      "title": "Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device.",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Mild Cognitive Impairment (MCI)",
        "Early Stages of Cognitive Decline",
        "Alzheimer's Disease Dementia",
        "Alzheimer's Disease Diagnosis",
        "Alzheimer's Disease and Related Dementias",
        "Parkinson's Disease",
        "Parkinson's Disease (PD)",
        "Parkinson's Disease With Wearing-off Motor Fluctuations",
        "Dementia (Diagnosis)",
        "Dementia MCI (Mild Cognitive Impairment)"
      ],
      "interventions": [
        {
          "name": "Structured wellness care",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Wearable brain-computer interface devices",
          "type": "DEVICE"
        },
        {
          "name": "Stem Cell Therapy - Experimental",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Control - Placebo Comparator",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DEVICE",
        "BIOLOGICAL",
        "OTHER"
      ],
      "sponsor": "Noah Tech, Corp.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "55 Years and older"
      },
      "enrollment_count": 600,
      "start_date": "2026-09-01",
      "completion_date": "2030-01-03",
      "has_results": false,
      "last_update_posted_date": "2026-03-10",
      "last_synced_at": "2026-07-23T18:13:46.216Z",
      "location_count": 1,
      "location_summary": "Palisades Park, New Jersey",
      "locations": [
        {
          "city": "Palisades Park",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07214974"
    },
    {
      "nct_id": "NCT06792877",
      "title": "Mindfulness for Cognition in Early-stage Alzheimer's Disease",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mild Cognitive Impairment (MCI)",
        "Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease",
        "TBI (Traumatic Brain Injury)",
        "Aging",
        "Healthy Elderly",
        "Alzheimer&Amp;Amp;#39;s Dementia (AD)"
      ],
      "interventions": [
        {
          "name": "Mindfulness Intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Waitlist then mindfulness",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "VA Boston Healthcare System",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "50 Years to 100 Years"
      },
      "enrollment_count": 100,
      "start_date": "2025-01-23",
      "completion_date": "2027-03-31",
      "has_results": false,
      "last_update_posted_date": "2025-01-27",
      "last_synced_at": "2026-07-23T18:13:46.216Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06792877"
    }
  ]
}