{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Edwards+Syndrome+%28Trisomy+18%29",
    "query": {
      "condition": "Edwards Syndrome (Trisomy 18)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 21,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Edwards+Syndrome+%28Trisomy+18%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T00:53:01.907Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00891852",
      "title": "Non-Invasive Determination of Fetal Chromosome Abnormalities",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome (Trisomy 21)",
        "Edward's Syndrome (Trisomy 18)",
        "Patau Syndrome (Trisomy 13)",
        "Klinefelter Syndrome (47, XXY)",
        "and Other Chromosome",
        "Abnormalities."
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Lenetix Medical Screening Laboratory",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 1000,
      "start_date": "2009-01",
      "completion_date": "2009-12",
      "has_results": false,
      "last_update_posted_date": "2009-05-01",
      "last_synced_at": "2026-07-22T00:53:01.907Z",
      "location_count": 7,
      "location_summary": "Rockville, Maryland • Moristown, New Jersey • Mineola, New York + 3 more",
      "locations": [
        {
          "city": "Rockville",
          "state": "Maryland"
        },
        {
          "city": "Moristown",
          "state": "New Jersey"
        },
        {
          "city": "Mineola",
          "state": "New York"
        },
        {
          "city": "New Hyde Park",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00891852"
    },
    {
      "nct_id": "NCT00971334",
      "title": "Noninvasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pregnancy",
        "Aneuploidy",
        "Down Syndrome",
        "Edwards Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Sequenom, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 2502,
      "start_date": "2009-08",
      "completion_date": "2011-12",
      "has_results": false,
      "last_update_posted_date": "2012-02-17",
      "last_synced_at": "2026-07-22T00:53:01.907Z",
      "location_count": 30,
      "location_summary": "Mobile, Alabama • La Mesa, California • San Diego, California + 21 more",
      "locations": [
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "La Mesa",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00971334"
    },
    {
      "nct_id": "NCT02109770",
      "title": "Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Microdeletion Syndromes",
        "Trisomy 21",
        "Trisomy 18",
        "Trisomy 13",
        "Sex Chromosome Abnormalities"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Natera, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 216,
      "start_date": "2012-10",
      "completion_date": "2019-08",
      "has_results": false,
      "last_update_posted_date": "2019-08-26",
      "last_synced_at": "2026-07-22T00:53:01.907Z",
      "location_count": 2,
      "location_summary": "San Carlos, California • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "San Carlos",
          "state": "California"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02109770"
    },
    {
      "nct_id": "NCT01852708",
      "title": "Development of Non-invasive Prenatal Screening Test for Microdeletions Based on Fetal DNA Isolated From Maternal Blood",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Trisomy 21",
        "Trisomy 18",
        "Trisomy 13",
        "Sex Chromosome Abnormalities",
        "Microdeletion Syndromes"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Natera, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1059,
      "start_date": "2012-11",
      "completion_date": "2020-10",
      "has_results": false,
      "last_update_posted_date": "2020-12-30",
      "last_synced_at": "2026-07-22T00:53:01.907Z",
      "location_count": 7,
      "location_summary": "San Carlos, California • San Gabriel, California • Washington D.C., District of Columbia + 4 more",
      "locations": [
        {
          "city": "San Carlos",
          "state": "California"
        },
        {
          "city": "San Gabriel",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "New Brunswick",
          "state": "New Jersey"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01852708"
    },
    {
      "nct_id": "NCT05004337",
      "title": "Verification of Risk Assignment for Whole Chromosome Using SNP-based NIPT in Vanishing Twin Pregnancies",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Vanishing Twin",
        "Trisomy 21",
        "Trisomy 13",
        "Trisomy 18"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Natera, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 126,
      "start_date": "2021-07-22",
      "completion_date": "2023-11-29",
      "has_results": false,
      "last_update_posted_date": "2024-09-25",
      "last_synced_at": "2026-07-22T00:53:01.907Z",
      "location_count": 21,
      "location_summary": "Los Angeles, California • Palo Alto, California • Aurora, Colorado + 15 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05004337"
    },
    {
      "nct_id": "NCT00847990",
      "title": "Non-Invasive Screening for Fetal Aneuploidy",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome",
        "Edwards Syndrome"
      ],
      "interventions": [
        {
          "name": "Maternal blood screening test for fetal aneuploidy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Sequenom, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 5000,
      "start_date": "2009-03",
      "completion_date": "2011-08",
      "has_results": false,
      "last_update_posted_date": "2011-09-05",
      "last_synced_at": "2026-07-22T00:53:01.907Z",
      "location_count": 25,
      "location_summary": "Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 18 more",
      "locations": [
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Laguna Hills",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00847990"
    },
    {
      "nct_id": "NCT01545674",
      "title": "Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Trisomy 13",
        "Trisomy 18",
        "Trisomy 21",
        "Aneuploidy"
      ],
      "interventions": [
        {
          "name": "Blood Draw",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Natera, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 937,
      "start_date": "2012-01",
      "completion_date": "2023-03",
      "has_results": false,
      "last_update_posted_date": "2023-03-23",
      "last_synced_at": "2026-07-22T00:53:01.907Z",
      "location_count": 24,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • San Francisco, California + 16 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01545674"
    },
    {
      "nct_id": "NCT03087357",
      "title": "VAlidation of a Lower Cost aneUploidy scrEen",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome",
        "Trisomy 18",
        "Trisomy 13"
      ],
      "interventions": [
        {
          "name": "SmartNIPT",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Women and Infants Hospital of Rhode Island",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 2443,
      "start_date": "2017-10-10",
      "completion_date": "2020-10-01",
      "has_results": false,
      "last_update_posted_date": "2022-09-22",
      "last_synced_at": "2026-07-22T00:53:01.907Z",
      "location_count": 13,
      "location_summary": "Los Angeles, California • Aurora, Colorado • Bridgeport, Connecticut + 9 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Bridgeport",
          "state": "Connecticut"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03087357"
    },
    {
      "nct_id": "NCT02317965",
      "title": "Non-Invasive Screening for Fetal Aneuploidy",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome",
        "Edwards Syndrome"
      ],
      "interventions": [
        {
          "name": "Maternal Blood Draw",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Progenity, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "54 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 54 Years · Female only"
      },
      "enrollment_count": 340,
      "start_date": "2015-03",
      "completion_date": "2018-11",
      "has_results": false,
      "last_update_posted_date": "2018-08-28",
      "last_synced_at": "2026-07-22T00:53:01.907Z",
      "location_count": 10,
      "location_summary": "Campbell, California • Long Beach, California • Denver, Colorado + 6 more",
      "locations": [
        {
          "city": "Campbell",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Englewood",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02317965"
    },
    {
      "nct_id": "NCT00770458",
      "title": "Non-Invasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome (Trisomy 21)",
        "Edwards Syndrome (Trisomy 18)",
        "Patau Syndrome (Trisomy 13)",
        "Turner Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Sequenom, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 1000,
      "start_date": "2008-06",
      "completion_date": "2009-12",
      "has_results": false,
      "last_update_posted_date": "2010-01-06",
      "last_synced_at": "2026-07-22T00:53:01.907Z",
      "location_count": 7,
      "location_summary": "La Jolla, California • San Diego, California • San Jose, California + 4 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Jose",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00770458"
    }
  ]
}