{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=FBN1%2C+TGFBR1%2C+TGFBR2%2C+ACTA2+or+MYH11+Genetic+Mutation",
    "query": {
      "condition": "FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic Mutation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 1,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T04:16:53.158Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01322165",
      "title": "National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Marfan Syndrome",
        "Turner Syndrome",
        "Ehlers-Danlos Syndrome",
        "Loeys-Dietz Syndrome",
        "FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic Mutation",
        "Bicuspid Aortic Valve Without Known Family History",
        "Bicuspid Aortic Valve With Family History",
        "Bicuspid Aortic Valve With Coarctation",
        "Familial Thoracic Aortic Aneurysm and Dissections",
        "Shprintzen-Goldberg Syndrome",
        "Other Aneur/Diss of Thoracic Aorta Not Due to Trauma, <50yo",
        "Other Congenital Heart Disease"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 3706,
      "start_date": "2007-11",
      "completion_date": "2016-09",
      "has_results": false,
      "last_update_posted_date": "2016-12-20",
      "last_synced_at": "2026-05-22T04:16:53.158Z",
      "location_count": 7,
      "location_summary": "Honolulu, Hawaii • Baltimore, Maryland • New York, New York + 3 more",
      "locations": [
        {
          "city": "Honolulu",
          "state": "Hawaii"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01322165"
    }
  ]
}