{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Facial+Rhytides&page=2",
    "query": {
      "condition": "Facial Rhytides",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Facial+Rhytides&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T18:20:35.707Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03228641",
      "title": "Evaluation of Safety and Efficacy of Micro-coring Device for Treatment of Facial Wrinkles and Skin Laxity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle",
        "Facial and Neck Skin Laxity"
      ],
      "interventions": [
        {
          "name": "micro-excisional skin removal with coring needle",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cytrellis Biosystems, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "40 Years to 75 Years"
      },
      "enrollment_count": 45,
      "start_date": "2016-06-01",
      "completion_date": "2017-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-25",
      "last_synced_at": "2026-07-22T18:20:35.707Z",
      "location_count": 6,
      "location_summary": "Sacramento, California • Miami, Florida • Chestnut Hill, Massachusetts + 3 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Chestnut Hill",
          "state": "Massachusetts"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03228641"
    },
    {
      "nct_id": "NCT05987917",
      "title": "Clinical and Histological Evaluation of BTL-785F Non-invasive Treatment for Facial Rejuvenation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "BTL-785-2",
          "type": "DEVICE"
        },
        {
          "name": "No Treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "BTL Industries Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 7,
      "start_date": "2021-01-25",
      "completion_date": "2022-01-03",
      "has_results": false,
      "last_update_posted_date": "2024-02-02",
      "last_synced_at": "2026-07-22T18:20:35.707Z",
      "location_count": 1,
      "location_summary": "Hackensack, New Jersey",
      "locations": [
        {
          "city": "Hackensack",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05987917"
    },
    {
      "nct_id": "NCT06218251",
      "title": "A Study to Evaluate Participant Satisfaction and Natural Outcomes Following Administration of BOTOX Cosmetic Injections in Adult Participants for Treatment of Upper Facial Lines",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Upper Facial Lines"
      ],
      "interventions": [
        {
          "name": "BOTOX",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "AbbVie",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2024-02-05",
      "completion_date": "2024-12-17",
      "has_results": true,
      "last_update_posted_date": "2025-11-24",
      "last_synced_at": "2026-07-22T18:20:35.707Z",
      "location_count": 7,
      "location_summary": "Birmingham, Alabama • San Francisco, California • Vista, California + 4 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Vista",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06218251"
    },
    {
      "nct_id": "NCT01379365",
      "title": "Cryo-Touch III Refinement Study Investigational Plan",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Facial Wrinkles",
        "Skin Aging"
      ],
      "interventions": [
        {
          "name": "Cryo-Touch III",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Pacira Pharmaceuticals, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "30 Years to 70 Years"
      },
      "enrollment_count": 88,
      "start_date": "2011-06",
      "completion_date": "2014-12",
      "has_results": false,
      "last_update_posted_date": "2015-03-24",
      "last_synced_at": "2026-07-22T18:20:35.707Z",
      "location_count": 1,
      "location_summary": "Redwood City, California",
      "locations": [
        {
          "city": "Redwood City",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01379365"
    },
    {
      "nct_id": "NCT03573271",
      "title": "Pivotal Study to Evaluate the Safety and Efficacy of a Micro-coring Device Treating Moderate to Severe Facial Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Laxity; Skin"
      ],
      "interventions": [
        {
          "name": "MCD",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cytrellis Biosystems, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "40 Years to 70 Years"
      },
      "enrollment_count": 30,
      "start_date": "2018-03-26",
      "completion_date": "2019-02-28",
      "has_results": false,
      "last_update_posted_date": "2026-04-09",
      "last_synced_at": "2026-07-22T18:20:35.707Z",
      "location_count": 5,
      "location_summary": "Sacramento, California • Miami, Florida • New York, New York + 2 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03573271"
    },
    {
      "nct_id": "NCT02261467",
      "title": "A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Forehead Rhytides",
        "Glabellar Rhytides"
      ],
      "interventions": [
        {
          "name": "OnabotulinumtoxinA",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Normal Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG"
      ],
      "sponsor": "Allergan",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 421,
      "start_date": "2014-10-21",
      "completion_date": "2016-04-26",
      "has_results": true,
      "last_update_posted_date": "2019-01-08",
      "last_synced_at": "2026-07-22T18:20:35.707Z",
      "location_count": 9,
      "location_summary": "Birmingham, Alabama • Glendale, Arizona • Santa Monica, California + 6 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Glendale",
          "state": "Arizona"
        },
        {
          "city": "Santa Monica",
          "state": "California"
        },
        {
          "city": "Greenwood Village",
          "state": "Colorado"
        },
        {
          "city": "Boca Raton",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02261467"
    },
    {
      "nct_id": "NCT05091788",
      "title": "Robotic Mechanical Coring for the Treatment of Moderate to Severe Facial Wrinkles",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Venus Aime",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Venus Concept",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "22 Years to 75 Years"
      },
      "enrollment_count": 70,
      "start_date": "2022-03-22",
      "completion_date": "2025-08-15",
      "has_results": false,
      "last_update_posted_date": "2024-01-26",
      "last_synced_at": "2026-07-22T18:20:35.707Z",
      "location_count": 2,
      "location_summary": "Chicago, Illinois • Charlotte, North Carolina",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05091788"
    },
    {
      "nct_id": "NCT06385171",
      "title": "Assessing the Impact of Botulinum Toxin Type A on Facial Wrinkles: A Comprehensive Clinical Investigation",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Botulinum toxin type A",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Global Aesthetics LLC",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "20 Years to 65 Years"
      },
      "enrollment_count": 500,
      "start_date": "2024-05-22",
      "completion_date": "2027-01-05",
      "has_results": false,
      "last_update_posted_date": "2024-05-24",
      "last_synced_at": "2026-07-22T18:20:35.707Z",
      "location_count": 2,
      "location_summary": "Cisco, Texas • Lubbock, Texas",
      "locations": [
        {
          "city": "Cisco",
          "state": "Texas"
        },
        {
          "city": "Lubbock",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06385171"
    },
    {
      "nct_id": "NCT06351293",
      "title": "A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Defyne Treatment in Nasolabial Fold",
          "type": "DEVICE"
        },
        {
          "name": "RHA3 Treatment in Nasolabial Fold",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Galderma R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 15,
      "start_date": "2024-02-21",
      "completion_date": "2025-04-30",
      "has_results": false,
      "last_update_posted_date": "2026-01-16",
      "last_synced_at": "2026-07-22T18:20:35.707Z",
      "location_count": 1,
      "location_summary": "Santa Rosa Beach, Florida",
      "locations": [
        {
          "city": "Santa Rosa Beach",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06351293"
    },
    {
      "nct_id": "NCT02096081",
      "title": "The Treatment of Glabellar Frown Lines",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Glabellar Frown Lines"
      ],
      "interventions": [
        {
          "name": "IncobotulinumtoxinA",
          "type": "DRUG"
        },
        {
          "name": "OnabotulinumtoxinA",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Merz North America, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 250,
      "start_date": "2014-02",
      "completion_date": "2014-11",
      "has_results": true,
      "last_update_posted_date": "2017-10-19",
      "last_synced_at": "2026-07-22T18:20:35.707Z",
      "location_count": 10,
      "location_summary": "Los Angeles, California • Sacramento, California • Santa Monica, California + 6 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Santa Monica",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02096081"
    }
  ]
}