{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Familial+Hypercholesterolemia+-+Heterozygous", "query": { "condition": "Familial Hypercholesterolemia - Heterozygous" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 47, "total_pages": 5, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Familial+Hypercholesterolemia+-+Heterozygous&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-06-10T14:17:44.138Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01623115", "title": "Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With Heterozygous Familial Hypercholesterolemia Not Adequately Controlled With Their Lipid-Modifying Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hypercholesterolemia" ], "interventions": [ { "name": "Alirocumab", "type": "DRUG" }, { "name": "Placebo (for alirocumab)", "type": "DRUG" }, { "name": "Lipid Modifying Therapy (LMT)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sanofi", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 486, "start_date": "2012-07", "completion_date": "2014-12", "has_results": true, "last_update_posted_date": "2016-02-08", "last_synced_at": "2026-06-10T14:17:44.138Z", "location_count": 26, "location_summary": "Bell Gardens, California • Long Beach, California • Los Angeles, California + 21 more", "locations": [ { "city": "Bell Gardens", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Mission Viejo", "state": "California" }, { "city": "Newport Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01623115" }, { "nct_id": "NCT00827606", "title": "Atorvastatin Three Year Pediatric Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Familial Hypercholesterolemia" ], "interventions": [ { "name": "atorvastatin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "15 Years", "sex": "ALL", "summary": "6 Years to 15 Years" }, "enrollment_count": 272, "start_date": "2009-03", "completion_date": "2013-10", "has_results": true, "last_update_posted_date": "2021-02-21", "last_synced_at": "2026-06-10T14:17:44.138Z", "location_count": 7, "location_summary": "Phoenix, Arizona • Washington D.C., District of Columbia • Gainesville, Florida + 3 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Gainesville", "state": "Florida" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00827606" }, { "nct_id": "NCT02666664", "title": "Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hypercholesterolemia", "Atherosclerotic Cardiovascular Diseases" ], "interventions": [ { "name": "ETC-1002", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Esperion Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2230, "start_date": "2016-01-21", "completion_date": "2018-03-28", "has_results": true, "last_update_posted_date": "2020-05-11", "last_synced_at": "2026-06-10T14:17:44.138Z", "location_count": 48, "location_summary": "Huntsville, Alabama • Cottonwood, Arizona • Phoenix, Arizona + 45 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Cottonwood", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Canoga Park", "state": "California" }, { "city": "Santa Rosa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02666664" }, { "nct_id": "NCT01266876", "title": "Study of the Safety and Efficacy of REGN727/SAR236553 in Patients With HeFH Hypercholesterolemia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypercholesterolemia" ], "interventions": [ { "name": "Alirocumab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Regeneron Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 77, "start_date": "2011-01", "completion_date": "2011-11", "has_results": true, "last_update_posted_date": "2015-09-22", "last_synced_at": "2026-06-10T14:17:44.138Z", "location_count": 17, "location_summary": "Huntsville, Alabama • Mission Viejo, California • Newport Beach, California + 14 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Mission Viejo", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Bridgeport", "state": "Connecticut" }, { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01266876" }, { "nct_id": "NCT00079859", "title": "Implitapide in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) on Maximal Concurrent Lipid-Lowering Therapy", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Familial Hypercholesterolemia" ], "interventions": [ { "name": "Implitapide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Medical Research Laboratories International", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 120, "start_date": "2003-10", "completion_date": "2005-04", "has_results": false, "last_update_posted_date": "2005-06-24", "last_synced_at": "2026-06-10T14:17:44.138Z", "location_count": 1, "location_summary": "Cincinnati, Ohio", "locations": [ { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00079859" }, { "nct_id": "NCT01475825", "title": "A Study of the Safety and Efficacy of Two Different Regimens of Mipomersen in Patients With Familial Hypercholesterolemia and Inadequately Controlled Low-Density Lipoprotein Cholesterol", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hypercholesterolemia", "Heterozygous Familial" ], "interventions": [ { "name": "mipomersen sodium 200 mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "mipomersen sodium 70 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Kastle Therapeutics, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 309, "start_date": "2011-12", "completion_date": "2015-12-29", "has_results": true, "last_update_posted_date": "2019-03-26", "last_synced_at": "2026-06-10T14:17:44.138Z", "location_count": 20, "location_summary": "Mission Viejo, California • Aurora, Colorado • Cooper City, Florida + 17 more", "locations": [ { "city": "Mission Viejo", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Cooper City", "state": "Florida" }, { "city": "Winter Park", "state": "Florida" }, { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT01475825" }, { "nct_id": "NCT03337308", "title": "A Study Evaluating the Safety and Efficacy of Bempedoic Acid Plus Ezetimibe Fixed-Dose Combination Compared to Bempedoic Acid, Ezetimibe, and Placebo in Patients Treated With Maximally Tolerated Statin Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hyperlipidemias" ], "interventions": [ { "name": "Bempedoic Acid + Ezetimibe Fixed-Dose Combination", "type": "COMBINATION_PRODUCT" }, { "name": "Bempedoic Acid", "type": "DRUG" }, { "name": "Ezetimibe", "type": "DRUG" }, { "name": "Placebos", "type": "DRUG" } ], "intervention_types": [ "COMBINATION_PRODUCT", "DRUG" ], "sponsor": "Esperion Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 382, "start_date": "2017-10-23", "completion_date": "2018-07-18", "has_results": true, "last_update_posted_date": "2020-04-08", "last_synced_at": "2026-06-10T14:17:44.138Z", "location_count": 5, "location_summary": "Ames, Iowa • Nashua, New Hampshire • Statesville, North Carolina + 2 more", "locations": [ { "city": "Ames", "state": "Iowa" }, { "city": "Nashua", "state": "New Hampshire" }, { "city": "Statesville", "state": "North Carolina" }, { "city": "Wilmington", "state": "North Carolina" }, { "city": "Knoxville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT03337308" }, { "nct_id": "NCT02326220", "title": "Study of Alirocumab (REGN727/SAR236553) in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) Undergoing Low-density Lipoprotein (LDL) Apheresis Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Heterozygous Familial Hypercholesterolemia" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Alirocumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Regeneron Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 62, "start_date": "2015-03-31", "completion_date": "2016-04-30", "has_results": true, "last_update_posted_date": "2020-05-01", "last_synced_at": "2026-06-10T14:17:44.138Z", "location_count": 7, "location_summary": "Aurora, Colorado • Hartford, Connecticut • Kansas City, Kansas + 4 more", "locations": [ { "city": "Aurora", "state": "Colorado" }, { "city": "Hartford", "state": "Connecticut" }, { "city": "Kansas City", "state": "Kansas" }, { "city": "Scarborough", "state": "Maine" }, { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT02326220" }, { "nct_id": "NCT03510884", "title": "An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hypercholesterolaemia" ], "interventions": [ { "name": "Alirocumab SAR236553 (REGN727)", "type": "DRUG" }, { "name": "Rosuvastatin", "type": "DRUG" }, { "name": "Atorvastatin", "type": "DRUG" }, { "name": "Simvastatin", "type": "DRUG" }, { "name": "Pravastatin", "type": "DRUG" }, { "name": "Lovastatin", "type": "DRUG" }, { "name": "Fluvastatin", "type": "DRUG" }, { "name": "Ezetimibe", "type": "DRUG" }, { "name": "Cholestyramine", "type": "DRUG" }, { "name": "Nicotinic acid", "type": "DRUG" }, { "name": "Fenofibrate", "type": "DRUG" }, { "name": "Omega-3 fatty acids", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sanofi", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "8 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "8 Years to 17 Years" }, "enrollment_count": 153, "start_date": "2018-05-31", "completion_date": "2022-08-05", "has_results": true, "last_update_posted_date": "2023-05-06", "last_synced_at": "2026-06-10T14:17:44.138Z", "location_count": 5, "location_summary": "Boca Raton, Florida • St Louis, Missouri • Charlotte, North Carolina + 2 more", "locations": [ { "city": "Boca Raton", "state": "Florida" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Charlotte", "state": "North Carolina" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT03510884" }, { "nct_id": "NCT00477594", "title": "Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Lipid Metabolism, Inborn Errors", "Hypercholesterolemia, Autosomal Dominant", "Hyperlipidemias", "Metabolic Diseases", "Hyperlipoproteinemia Type II", "Metabolism, Inborn Errors", "Genetic Diseases, Inborn", "Infant, Newborn, Diseases", "Metabolic Disorder", "Congenital Abnormalities", "Hypercholesterolemia", "Hyperlipoproteinemias", "Dyslipidemias", "Lipid Metabolism Disorders" ], "interventions": [ { "name": "mipomersen sodium", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Kastle Therapeutics, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 21, "start_date": "2007-05", "completion_date": "2011-07", "has_results": true, "last_update_posted_date": "2016-09-09", "last_synced_at": "2026-06-10T14:17:44.138Z", "location_count": 5, "location_summary": "Chicago, Illinois • Auburn, Maine • Biddeford, Maine + 2 more", "locations": [ { "city": "Chicago", "state": "Illinois" }, { "city": "Auburn", "state": "Maine" }, { "city": "Biddeford", "state": "Maine" }, { "city": "Scarborough", "state": "Maine" }, { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00477594" } ] }