{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Fetal+Membranes%2C+Premature+Rupture",
    "query": {
      "condition": "Fetal Membranes, Premature Rupture"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 40,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Fetal+Membranes%2C+Premature+Rupture&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T12:14:24.974Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03168178",
      "title": "Intrapartum Fever: Antibiotics Versus no Treatment",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Chorioamnionitis",
        "Intrapartum Fever",
        "Intra-amniotic Infection"
      ],
      "interventions": [
        {
          "name": "Standard Antibiotic Treatment",
          "type": "DRUG"
        },
        {
          "name": "No Antibiotic Treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2017-06-08",
      "completion_date": "2018-07-26",
      "has_results": false,
      "last_update_posted_date": "2018-10-23",
      "last_synced_at": "2026-06-10T12:14:24.974Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03168178"
    },
    {
      "nct_id": "NCT02536352",
      "title": "Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Preterm Birth",
        "Preterm Labor",
        "Bacteremia",
        "Preterm Premature Rupture of Fetal Membranes"
      ],
      "interventions": [
        {
          "name": "Prenatal vitamin-mineral containing 3 mg fluoride",
          "type": "DRUG"
        },
        {
          "name": "Prenatal vitamin-mineral containing 0 mg fluoride",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 55 Years · Female only"
      },
      "enrollment_count": 43,
      "start_date": "2015-10",
      "completion_date": "2019-10-01",
      "has_results": false,
      "last_update_posted_date": "2019-11-05",
      "last_synced_at": "2026-06-10T12:14:24.974Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02536352"
    },
    {
      "nct_id": "NCT00290199",
      "title": "Foley Catheter for Labor Induction in Women With Term and Near Term Membrane Rupture",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fetal Membranes, Premature Rupture",
        "Labor, Induced/IS"
      ],
      "interventions": [
        {
          "name": "Transcervical Foley catheter",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "12 Years to 55 Years · Female only"
      },
      "enrollment_count": 169,
      "start_date": "2005-12",
      "completion_date": "2008-05",
      "has_results": true,
      "last_update_posted_date": "2017-05-23",
      "last_synced_at": "2026-06-10T12:14:24.974Z",
      "location_count": 3,
      "location_summary": "Birmingham, Alabama • Newark, Delaware • Greenville, South Carolina",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Greenville",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00290199"
    },
    {
      "nct_id": "NCT05322252",
      "title": "Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Abortion, Second Trimester",
        "PPROM",
        "Rupture, Spontaneous",
        "Fetal Demise",
        "Fetal Death",
        "Fetal Demise From Miscarriage",
        "Fetal Death Before 22 Weeks With Retention of Dead Fetus",
        "Pregnancy Loss",
        "Pregnancy Complications"
      ],
      "interventions": [
        {
          "name": "Mifepristone",
          "type": "DRUG"
        },
        {
          "name": "Misoprostol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 30,
      "start_date": "2022-07-01",
      "completion_date": "2025-07-14",
      "has_results": true,
      "last_update_posted_date": "2026-04-07",
      "last_synced_at": "2026-06-10T12:14:24.974Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05322252"
    },
    {
      "nct_id": "NCT03576560",
      "title": "Selective Use of Antibiotics in Neonates Born to Mothers With Suspected Chorioamnionitis",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chorioamnionitis"
      ],
      "interventions": [
        {
          "name": "Retrospective Chart Review",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Pediatrix",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Weeks",
        "maximum_age": "42 Weeks",
        "sex": "FEMALE",
        "summary": "35 Weeks to 42 Weeks · Female only"
      },
      "enrollment_count": 768,
      "start_date": "2017-06-26",
      "completion_date": "2019-05-01",
      "has_results": false,
      "last_update_posted_date": "2025-06-03",
      "last_synced_at": "2026-06-10T12:14:24.974Z",
      "location_count": 1,
      "location_summary": "Greensboro, North Carolina",
      "locations": [
        {
          "city": "Greensboro",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03576560"
    },
    {
      "nct_id": "NCT04451109",
      "title": "Dilapan-S®: A Multicenter US E-registry",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Post Term Pregnancy",
        "Premature Rupture of Membrane",
        "Fetal Growth Retardation",
        "Oligohydramnios",
        "Gestational Diabetes",
        "High Blood Pressure in Pregnancy"
      ],
      "interventions": [
        {
          "name": "Dilapan-S",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medicem Technology s.r.o.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 1200,
      "start_date": "2020-12-01",
      "completion_date": "2025-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-11-22",
      "last_synced_at": "2026-06-10T12:14:24.974Z",
      "location_count": 1,
      "location_summary": "Galveston, Texas",
      "locations": [
        {
          "city": "Galveston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04451109"
    },
    {
      "nct_id": "NCT01975792",
      "title": "Fetal Thymus Involution as a Predictor of Adverse Neonatal Outcomes",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Women Admitted to Labor and Delivery for the Management of Preterm Labor and/or Preterm Premature Rupture of Membranes (PPROM)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 125,
      "start_date": "2013-03",
      "completion_date": "2014-04",
      "has_results": false,
      "last_update_posted_date": "2017-03-30",
      "last_synced_at": "2026-06-10T12:14:24.974Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01975792"
    },
    {
      "nct_id": "NCT05345457",
      "title": "Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Pregnancy Preterm",
        "Pregnancy Prom",
        "PROM, Preterm (Pregnancy)",
        "PROM (Pregnancy)",
        "Premat Rupture Membranes Preterm Unspec to Length of Time Between Rupture/Labor",
        "Premature Birth"
      ],
      "interventions": [
        {
          "name": "Azithromycin Pill",
          "type": "DRUG"
        },
        {
          "name": "Amoxicillin Pill",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University Hospitals Cleveland Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 88,
      "start_date": "2023-01-13",
      "completion_date": "2027-06",
      "has_results": false,
      "last_update_posted_date": "2025-04-22",
      "last_synced_at": "2026-06-10T12:14:24.974Z",
      "location_count": 3,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05345457"
    },
    {
      "nct_id": "NCT00201656",
      "title": "Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Fetal Membranes, Premature Rupture"
      ],
      "interventions": [
        {
          "name": "Retention of Cerclage",
          "type": "PROCEDURE"
        },
        {
          "name": "Removal of Cerclage",
          "type": "PROCEDURE"
        },
        {
          "name": "Removal vs. Retention of Cervical Cerclage",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Obstetrix Medical Group",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 60 Years · Female only"
      },
      "enrollment_count": 58,
      "start_date": "2004-11",
      "completion_date": "2014-04",
      "has_results": false,
      "last_update_posted_date": "2014-12-19",
      "last_synced_at": "2026-06-10T12:14:24.974Z",
      "location_count": 23,
      "location_summary": "Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 18 more",
      "locations": [
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Laguna Hills",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00201656"
    },
    {
      "nct_id": "NCT04478942",
      "title": "PROMMO Trial: Oral Misoprostol vs IV Oxytocin",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Premature Rupture of Membrane",
        "Induction of Labor Affected Fetus / Newborn"
      ],
      "interventions": [
        {
          "name": "Misoprostol Oral Product",
          "type": "DRUG"
        },
        {
          "name": "Intravenous Oxytocin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 138,
      "start_date": "2020-10-26",
      "completion_date": "2025-01-14",
      "has_results": false,
      "last_update_posted_date": "2025-08-28",
      "last_synced_at": "2026-06-10T12:14:24.974Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04478942"
    }
  ]
}