{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Fontan+Physiology",
    "query": {
      "condition": "Fontan Physiology"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 23,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Fontan+Physiology&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T05:26:20.042Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01815502",
      "title": "Study of Effects of Sildenafil on Patients With Fontan Heart Circulation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Single Ventricle Heart Disease After Fontan Surgery"
      ],
      "interventions": [
        {
          "name": "Cardiac catheterization",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "3 Years to 40 Years"
      },
      "enrollment_count": 20,
      "start_date": "2013-02",
      "completion_date": "2014-12",
      "has_results": true,
      "last_update_posted_date": "2018-12-07",
      "last_synced_at": "2026-05-22T05:26:20.042Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01815502"
    },
    {
      "nct_id": "NCT01149603",
      "title": "The Destination Therapy Evaluation for Failing Fontan Study",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Failing Fontan Physiology",
        "Failing Fontan",
        "Single-ventricle",
        "Single-ventricle Fontan",
        "Single-ventricle Physiology"
      ],
      "interventions": [
        {
          "name": "HeartMate II Ventricular Assist Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Timothy Icenogle, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2010-07",
      "completion_date": "2017-09-19",
      "has_results": false,
      "last_update_posted_date": "2017-09-21",
      "last_synced_at": "2026-05-22T05:26:20.042Z",
      "location_count": 1,
      "location_summary": "Spokane, Washington",
      "locations": [
        {
          "city": "Spokane",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01149603"
    },
    {
      "nct_id": "NCT00211081",
      "title": "Spironolactone in Patients With Single Ventricle Heart",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Congenital Disorders"
      ],
      "interventions": [
        {
          "name": "Spironolactone (drug)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2004-11",
      "completion_date": "2008-06",
      "has_results": true,
      "last_update_posted_date": "2017-11-06",
      "last_synced_at": "2026-05-22T05:26:20.042Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00211081"
    },
    {
      "nct_id": "NCT00974025",
      "title": "Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fontan Procedure",
        "Hypoplastic Left Heart Syndrome",
        "Tricuspid Atresia"
      ],
      "interventions": [
        {
          "name": "Vitamin C",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "8 Years to 25 Years"
      },
      "enrollment_count": 53,
      "start_date": "2009-06",
      "completion_date": "2010-03",
      "has_results": false,
      "last_update_posted_date": "2017-06-01",
      "last_synced_at": "2026-05-22T05:26:20.042Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00974025"
    },
    {
      "nct_id": "NCT05206955",
      "title": "Study of Tadalafil vs. Placebo for Improving Hemodynamics and End-Organ Dysfunction in Fontan Physiology",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Fontan Palliation"
      ],
      "interventions": [
        {
          "name": "Tadalafil",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 80,
      "start_date": "2022-09-16",
      "completion_date": "2026-11",
      "has_results": false,
      "last_update_posted_date": "2025-11-14",
      "last_synced_at": "2026-05-22T05:26:20.042Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05206955"
    },
    {
      "nct_id": "NCT02741115",
      "title": "Fontan Udenafil Exercise Longitudinal Assessment Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Single Ventricle Heart Disease"
      ],
      "interventions": [
        {
          "name": "Udenafil",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mezzion Pharma Co. Ltd",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "12 Years to 18 Years"
      },
      "enrollment_count": 400,
      "start_date": "2016-07-22",
      "completion_date": "2019-04-30",
      "has_results": true,
      "last_update_posted_date": "2025-06-17",
      "last_synced_at": "2026-05-22T05:26:20.042Z",
      "location_count": 26,
      "location_summary": "Phoenix, Arizona • Los Angeles, California • San Diego, California + 22 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02741115"
    },
    {
      "nct_id": "NCT04463394",
      "title": "The Hemodynamic Effects of Vasopressin in Patients With Fontan Physiology",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Hypotension",
        "Fontan Physiology"
      ],
      "interventions": [
        {
          "name": "Vasopressin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 28,
      "start_date": "2020-08-12",
      "completion_date": "2022-02-15",
      "has_results": false,
      "last_update_posted_date": "2025-05-14",
      "last_synced_at": "2026-05-22T05:26:20.042Z",
      "location_count": 2,
      "location_summary": "Stanford, California",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04463394"
    },
    {
      "nct_id": "NCT04672538",
      "title": "Fontan Physiology Ventilation Strategy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anesthesia",
        "Congenital Heart Disease"
      ],
      "interventions": [
        {
          "name": "Low Vt protocol",
          "type": "PROCEDURE"
        },
        {
          "name": "High Vt protocol",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 32,
      "start_date": "2021-03-02",
      "completion_date": "2023-05-15",
      "has_results": false,
      "last_update_posted_date": "2023-05-17",
      "last_synced_at": "2026-05-22T05:26:20.042Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04672538"
    },
    {
      "nct_id": "NCT00480740",
      "title": "The Pharmacology and Hemodynamics of Dexmedetomidine in Children With Congenital Heart Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Cardiac Transplant",
        "Patent Ductus Arterious",
        "Atrial Septal Defect",
        "Bidirectional Cavopulmonary Anastomosis"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Children's National Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "Up to 18 Years"
      },
      "enrollment_count": 41,
      "start_date": "2006-12",
      "completion_date": "2011-10",
      "has_results": true,
      "last_update_posted_date": "2015-06-26",
      "last_synced_at": "2026-05-22T05:26:20.042Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00480740"
    },
    {
      "nct_id": "NCT01563757",
      "title": "Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle Physiology",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fontan Physiology Patients With PB or PLE",
        "Fontan Physiology Patients Without PB or PLE"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Medical College of Wisconsin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Months",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "6 Months and older"
      },
      "enrollment_count": 20,
      "start_date": "2012-03",
      "completion_date": "2013-09",
      "has_results": false,
      "last_update_posted_date": "2013-10-29",
      "last_synced_at": "2026-05-22T05:26:20.042Z",
      "location_count": 1,
      "location_summary": "Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01563757"
    }
  ]
}