{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Freeman-Burian+Syndrome",
    "query": {
      "condition": "Freeman-Burian Syndrome"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 5,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-21T23:32:12.992Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06801535",
      "title": "Efficacy of 3D-Printed Mouth Splints",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Microstomia"
      ],
      "interventions": [
        {
          "name": "Splint",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "2 Years to 99 Years"
      },
      "enrollment_count": 10,
      "start_date": "2025-02-21",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-12-17",
      "last_synced_at": "2026-07-21T23:32:12.992Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06801535"
    },
    {
      "nct_id": "NCT01307475",
      "title": "Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Arthrogryposis",
        "Craniofacial Abnormalities",
        "Posttraumatic Stress Disorder",
        "Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "PTSD Checklist-Specific",
          "type": "OTHER"
        },
        {
          "name": "Modified Flanagan Quality of Life Scale",
          "type": "OTHER"
        },
        {
          "name": "Center for Epidemiologic Studies Depression Scale",
          "type": "OTHER"
        },
        {
          "name": "Functional Enquiry Form",
          "type": "OTHER"
        },
        {
          "name": "Strength, Joint ROM, Girth and Length Measurements",
          "type": "OTHER"
        },
        {
          "name": "Study Physical Examination",
          "type": "OTHER"
        },
        {
          "name": "PTSD, Depression, and FSS-Focused Examination",
          "type": "OTHER"
        },
        {
          "name": "Freeman-Sheldon Specific Quality of Life Survey",
          "type": "OTHER"
        },
        {
          "name": "Lactate, Glucose, and Adenosine Triphosphate Blood Levels",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Freeman-Sheldon Research Group, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 6,
      "start_date": "2011-02",
      "completion_date": "2017-04-01",
      "has_results": false,
      "last_update_posted_date": "2017-04-04",
      "last_synced_at": "2026-07-21T23:32:12.992Z",
      "location_count": 1,
      "location_summary": "Buckhannon, West Virginia",
      "locations": [
        {
          "city": "Buckhannon",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01307475"
    },
    {
      "nct_id": "NCT01144741",
      "title": "Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Freeman-Sheldon Syndrome",
        "Arthrogryposis Distal Type 2A",
        "Whistling Face Syndrome",
        "Craniocarpotarsal Dysplasia",
        "Craniocarpotarsal Dystrophy",
        "Freeman-Sheldon Syndrome Variant",
        "Sheldon-Hall Syndrome",
        "Arthrogryposis Distal Type 2B",
        "Gordon Syndrome",
        "Arthrogryposis Distal Type 3",
        "Arthrogryposis Distal Type 1",
        "Arthrogryposis, Distal, Type 1A",
        "Arthrogryposis Distal Type 1B",
        "Arthrogryposis, Distal",
        "Craniofacial Abnormalities",
        "Arthrogryposis"
      ],
      "interventions": [
        {
          "name": "PTSD Checklist-Civilian (PCL-C)",
          "type": "OTHER"
        },
        {
          "name": "Modified Flanagan Quality of Life Scale",
          "type": "OTHER"
        },
        {
          "name": "Center for Epidemiologic Studies Depression Scale (CES-D)",
          "type": "OTHER"
        },
        {
          "name": "Functional Enquiry (or Review of Systems) Form",
          "type": "OTHER"
        },
        {
          "name": "Study of Therapeutic Outcomes and Practices in Freeman-Sheldon Syndrome (STOP-FSS) Questionnaire",
          "type": "OTHER"
        },
        {
          "name": "FSRG Semi-Structured Quality of Life Interview (FSRG SSQLI)",
          "type": "OTHER"
        },
        {
          "name": "Medical Records Review",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Freeman-Sheldon Research Group, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 2,
      "start_date": "2010-02",
      "completion_date": "2022-06-14",
      "has_results": false,
      "last_update_posted_date": "2022-06-21",
      "last_synced_at": "2026-07-21T23:32:12.992Z",
      "location_count": 1,
      "location_summary": "Buckhannon, West Virginia",
      "locations": [
        {
          "city": "Buckhannon",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01144741"
    },
    {
      "nct_id": "NCT01306994",
      "title": "Study of Resting and Exercising Body Functioning in Freeman-Sheldon Syndrome and Related Conditions",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Arthrogryposis",
        "Craniofacial Abnormalities"
      ],
      "interventions": [
        {
          "name": "Lactate, Glucose, and Adenosine Triphosphate Blood Levels",
          "type": "OTHER"
        },
        {
          "name": "Physiological Stress Test",
          "type": "PROCEDURE"
        },
        {
          "name": "Functional Enquiry Form",
          "type": "OTHER"
        },
        {
          "name": "Strength, Joint ROM, Girth and Length Measurements",
          "type": "OTHER"
        },
        {
          "name": "Study Physical Examination",
          "type": "OTHER"
        },
        {
          "name": "Observational Gait Analysis",
          "type": "OTHER"
        },
        {
          "name": "Mental Health Interview",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "PROCEDURE"
      ],
      "sponsor": "Freeman-Sheldon Research Group, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 0,
      "start_date": "2014-03",
      "completion_date": "2022-06",
      "has_results": false,
      "last_update_posted_date": "2022-06-06",
      "last_synced_at": "2026-07-21T23:32:12.992Z",
      "location_count": 1,
      "location_summary": "Buckhannon, West Virginia",
      "locations": [
        {
          "city": "Buckhannon",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01306994"
    },
    {
      "nct_id": "NCT05419245",
      "title": "Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Freeman-Burian Syndrome",
        "Freeman-Sheldon Syndrome",
        "Whistling Face Syndrome",
        "Sheldon-Hall Syndrome",
        "Freeman-Sheldon Syndrome Variant",
        "Arthrogryposis Distal Type 1",
        "Arthrogryposis Distal Type 3",
        "Gordon Syndrome"
      ],
      "interventions": [
        {
          "name": "Guided Health History for Freeman-Burian Syndrome Questionnaire",
          "type": "OTHER"
        },
        {
          "name": "Freeman-Burian syndrome Semi-Structured Quality of Life Interview",
          "type": "OTHER"
        },
        {
          "name": "Medical Records Review",
          "type": "OTHER"
        },
        {
          "name": "PTSD Checklist for DSM-5",
          "type": "OTHER"
        },
        {
          "name": "Modified Flanagan Quality of Life Scale",
          "type": "OTHER"
        },
        {
          "name": "Center for Epidemiologic Studies Depression Scale",
          "type": "OTHER"
        },
        {
          "name": "Review of Systems",
          "type": "OTHER"
        },
        {
          "name": "FACE-Q | Craniofacial - Appearance of the Face",
          "type": "OTHER"
        },
        {
          "name": "FACE-Q | Craniofacial - Appearance Distress",
          "type": "OTHER"
        },
        {
          "name": "FACE-Q | Craniofacial - Facial Function",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Dufresne, Craig, MD, PC",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 20,
      "start_date": "2022-06-01",
      "completion_date": "2023-12",
      "has_results": false,
      "last_update_posted_date": "2022-07-19",
      "last_synced_at": "2026-07-21T23:32:12.992Z",
      "location_count": 1,
      "location_summary": "Fairfax, Virginia",
      "locations": [
        {
          "city": "Fairfax",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05419245"
    }
  ]
}