{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=GJB2+Gene+Mutation",
    "query": {
      "condition": "GJB2 Gene Mutation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 2,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-04T12:57:49.138Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07627971",
      "title": "Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "GJB2-mediated Hearing Loss",
        "GJB2 Gene Mutation",
        "DFNB1A"
      ],
      "interventions": [
        {
          "name": "SKY-GJB2",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Skylark Bio Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "9 Months",
        "maximum_age": "7 Years",
        "sex": "ALL",
        "summary": "9 Months to 7 Years"
      },
      "enrollment_count": 10,
      "start_date": "2026-05-28",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2026-08-27",
      "last_synced_at": "2026-09-04T12:57:49.138Z",
      "location_count": 4,
      "location_summary": "Bethesda, Maryland • Boston, Massachusetts • Oklahoma City, Oklahoma + 1 more",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        },
        {
          "city": "Allentown",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07627971"
    },
    {
      "nct_id": "NCT06019481",
      "title": "A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF)",
        "Biallelic Mutations in the Gap Junction Beta 2 (GJB2) Gene",
        "Digenic Mutations in GJB2/Gap Junction Beta 6 (GJB6) Genes"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Regeneron Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "7 Years",
        "sex": "ALL",
        "summary": "Up to 7 Years"
      },
      "enrollment_count": 0,
      "start_date": "2025-06-30",
      "completion_date": "2030-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-05-15",
      "last_synced_at": "2026-09-04T12:57:49.138Z",
      "location_count": 2,
      "location_summary": "Phoenix, Arizona • Columbus, Ohio",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06019481"
    }
  ]
}