{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Genetics%2FBirth+Defects&page=47", "query": { "condition": "Genetics/Birth Defects", "page": 47 }, "page_size": 10 }, "pagination": { "page": 47, "page_size": 10, "total_count": 8007, "total_pages": 801, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Genetics%2FBirth+Defects&page=48&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Genetics%2FBirth+Defects&page=46&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-24T16:22:16.197Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00001305", "title": "Growth Hormone Therapy in Osteogenesis Imperfecta", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Osteogenesis Imperfecta" ], "interventions": [ { "name": "Humatrope", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Years", "maximum_age": "16 Years", "sex": "ALL", "summary": "3 Years to 16 Years" }, "enrollment_count": 42, "start_date": "1991-11-05", "completion_date": "2017-05-19", "has_results": true, "last_update_posted_date": "2019-01-29", "last_synced_at": "2026-10-24T16:22:16.197Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00001305" }, { "nct_id": "NCT06079372", "title": "Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hypophosphatasia" ], "interventions": [ { "name": "ALXN1850", "type": "DRUG" }, { "name": "asfotase alfa", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alexion Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "11 Years", "sex": "ALL", "summary": "2 Years to 11 Years" }, "enrollment_count": 43, "start_date": "2024-04-02", "completion_date": "2028-02-29", "has_results": false, "last_update_posted_date": "2026-05-05", "last_synced_at": "2026-10-24T16:22:16.197Z", "location_count": 6, "location_summary": "Hartford, Connecticut • Baltimore, Maryland • Minneapolis, Minnesota + 3 more", "locations": [ { "city": "Hartford", "state": "Connecticut" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Minneapolis", "state": "Minnesota" }, { "city": "Kansas City", "state": "Missouri" }, { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT06079372" }, { "nct_id": "NCT00001377", "title": "Familial Prostate Cancer", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Neoplastic Syndromes, Hereditary", "Prostatic Neoplasms" ], "interventions": [], "intervention_types": [], "sponsor": "National Cancer Institute (NCI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 200, "start_date": "1993-12", "completion_date": "2000-12", "has_results": false, "last_update_posted_date": "2008-03-04", "last_synced_at": "2026-10-24T16:22:16.197Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00001377" }, { "nct_id": "NCT01746095", "title": "Efficacy and Safety Study of AeroVanc for the Treatment of Persistent MRSA Lung Infection in Cystic Fibrosis Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "Vancomycin hydrochloride inhalation powder", "type": "DRUG" }, { "name": "Placebo inhalation powder", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Savara Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 87, "start_date": "2013-03", "completion_date": "2014-11", "has_results": true, "last_update_posted_date": "2020-01-13", "last_synced_at": "2026-10-24T16:22:16.197Z", "location_count": 38, "location_summary": "Mobile, Alabama • Little Rock, Arkansas • Los Angeles, California + 32 more", "locations": [ { "city": "Mobile", "state": "Alabama" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Los Angeles", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Hollywood", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01746095" }, { "nct_id": "NCT03478839", "title": "Study of People With Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Generalized Arterial Calcification of Infancy", "Autosomal Recessive Hypophosphatemic Rickets Type2" ], "interventions": [], "intervention_types": [], "sponsor": "National Human Genome Research Institute (NHGRI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Year", "maximum_age": "110 Years", "sex": "ALL", "summary": "1 Year to 110 Years" }, "enrollment_count": 48, "start_date": "2018-04-17", "completion_date": "2020-12-31", "has_results": false, "last_update_posted_date": "2026-07-16", "last_synced_at": "2026-10-24T16:22:16.197Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT03478839" }, { "nct_id": "NCT05630794", "title": "Testing for Safety and Colorectal Cancer Preventive Effects of ONC201", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Colorectal Adenomatous Polyp", "Colorectal Carcinoma", "Familial Adenomatous Polyposis", "Multiple Adenomatous Polyps" ], "interventions": [ { "name": "Biopsy Procedure", "type": "PROCEDURE" }, { "name": "Biospecimen Collection", "type": "PROCEDURE" }, { "name": "Colonoscopy", "type": "PROCEDURE" }, { "name": "Dordaviprone Hydrochloride", "type": "DRUG" }, { "name": "Endoscopic Procedure", "type": "PROCEDURE" }, { "name": "Questionnaire Administration", "type": "OTHER" }, { "name": "Sigmoidoscopy", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE", "DRUG", "OTHER" ], "sponsor": "National Cancer Institute (NCI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 36, "start_date": "2025-10-06", "completion_date": "2029-05-01", "has_results": false, "last_update_posted_date": "2026-10-15", "last_synced_at": "2026-10-24T16:22:16.197Z", "location_count": 5, "location_summary": "Ann Arbor, Michigan • St Louis, Missouri • Cleveland, Ohio + 2 more", "locations": [ { "city": "Ann Arbor", "state": "Michigan" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Cleveland", "state": "Ohio" }, { "city": "Columbus", "state": "Ohio" }, { "city": "Providence", "state": "Rhode Island" } ], "official_url": "https://clinicaltrials.gov/study/NCT05630794" }, { "nct_id": "NCT05833022", "title": "Patient Characteristics and Treatment Patterns From Early Crizanlizumab Use in Real-world Setting: Preliminary Analysis From Select Sickle Cell Centers", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Sickle Cell Disease" ], "interventions": [], "intervention_types": [], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": null, "eligibility": { "minimum_age": "16 Years", "maximum_age": null, "sex": "ALL", "summary": "16 Years and older" }, "enrollment_count": 297, "start_date": "2021-07-30", "completion_date": "2022-04-18", "has_results": false, "last_update_posted_date": "2023-04-27", "last_synced_at": "2026-10-24T16:22:16.197Z", "location_count": 11, "location_summary": "Birmingham, Alabama • Wilmington, Delaware • St. Petersburg, Florida + 8 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Wilmington", "state": "Delaware" }, { "city": "St. Petersburg", "state": "Florida" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT05833022" }, { "nct_id": "NCT01798966", "title": "Twenty-four Hour Intraocular Pressure Patterns in Patients With Uncontrolled Thyroid Eye Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Thyroid Eye Disease" ], "interventions": [ { "name": "SENSIMED Triggerfish", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Sensimed AG", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "18 Years to 90 Years" }, "enrollment_count": 10, "start_date": "2013-02", "completion_date": "2013-06", "has_results": true, "last_update_posted_date": "2016-03-11", "last_synced_at": "2026-10-24T16:22:16.197Z", "location_count": 1, "location_summary": "La Jolla, California", "locations": [ { "city": "La Jolla", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01798966" }, { "nct_id": "NCT01736566", "title": "A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Healthy Adults (Full Study and Extension Phase)", "Hypertrophic Cardiomyopathy or Dilated Cardiomyopathy" ], "interventions": [ { "name": "Family History + Whole Genome Sequencing", "type": "OTHER" }, { "name": "Family History Only", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Brigham and Women's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "18 Years to 90 Years" }, "enrollment_count": 213, "start_date": "2011-12", "completion_date": "2021-01-02", "has_results": true, "last_update_posted_date": "2024-08-27", "last_synced_at": "2026-10-24T16:22:16.197Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01736566" }, { "nct_id": "NCT03938272", "title": "An Extension Study to Evaluate the Long-term Efficacy and Safety of Oxabact in Patients With Primary Hyperoxaluria", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hyperoxaluria, Primary" ], "interventions": [ { "name": "Oxabact OC5 - Oxalobacter formigenes Strain HC-1", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "OxThera", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Years", "maximum_age": null, "sex": "ALL", "summary": "3 Years and older" }, "enrollment_count": 22, "start_date": "2019-03-14", "completion_date": "2021-07-14", "has_results": true, "last_update_posted_date": "2021-12-08", "last_synced_at": "2026-10-24T16:22:16.197Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT03938272" } ] }