{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Head+Injury%2C+Open", "query": { "condition": "Head Injury, Open" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 31, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Head+Injury%2C+Open&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-06-11T06:01:57.203Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00174980", "title": "Study of Oxycyte in Severe Closed Head Injury", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Traumatic Brain Injury" ], "interventions": [ { "name": "Oxycyte", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Tenax Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 9, "start_date": "2005-09", "completion_date": "2008-04", "has_results": true, "last_update_posted_date": "2026-02-24", "last_synced_at": "2026-06-11T06:01:57.203Z", "location_count": 1, "location_summary": "Richmond, Virginia", "locations": [ { "city": "Richmond", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00174980" }, { "nct_id": "NCT07600320", "title": "Fareon Open Label Device Clinical Trial", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cognitive Dysfunction", "Acquired Brain Injury", "Traumatic Brain Injury" ], "interventions": [ { "name": "Fareon device", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Icahn School of Medicine at Mount Sinai", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": null, "sex": "ALL", "summary": "16 Years and older" }, "enrollment_count": 30, "start_date": "2026-05-01", "completion_date": "2027-04-30", "has_results": false, "last_update_posted_date": "2026-05-20", "last_synced_at": "2026-06-11T06:01:57.203Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT07600320" }, { "nct_id": "NCT03880188", "title": "Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds", "overall_status": "UNKNOWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Wounds and Injuries", "Wound Infection", "Facial Bones Fracture", "Soft Tissue Injuries", "Skull Fractures", "Surgical Wound", "Surgical Wound Infection", "Wound Healing", "Disturbance of Wound Healing", "Wound; Head, Multiple", "Wound; Head, Scalp", "Wound; Head", "Wound Complication", "Wound Dehiscence", "Wound of Skin", "Wound Open", "Wounds, Penetrating", "Wounds, Nonpenetrating", "Wounds" ], "interventions": [], "intervention_types": [], "sponsor": "Dufresne, Craig, MD, PC", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 20, "start_date": "2022-09-10", "completion_date": "2024-06-30", "has_results": false, "last_update_posted_date": "2022-06-16", "last_synced_at": "2026-06-11T06:01:57.203Z", "location_count": 1, "location_summary": "Fairfax, Virginia", "locations": [ { "city": "Fairfax", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT03880188" }, { "nct_id": "NCT06081283", "title": "Antiseizure Medication in Seizure Networks at Early Acute Brain Injury", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Brain Injuries, Acute", "Brain Injuries, Traumatic", "Brain Ischemia", "Brain Hypoxia", "Hypoxia-Ischemia, Brain", "Heart Arrest", "Stroke", "Intracranial Hemorrhages", "Coma", "Persistent Vegetative State" ], "interventions": [ { "name": "Phenobarbital Sodium Injection", "type": "DRUG" }, { "name": "Levetiracetam", "type": "DRUG" }, { "name": "Lacosamide Injectable Product", "type": "DRUG" }, { "name": "Valproate Sodium", "type": "DRUG" }, { "name": "Fosphenytoin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of North Carolina, Chapel Hill", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Months", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Months to 70 Years" }, "enrollment_count": 5, "start_date": "2023-11-20", "completion_date": "2025-01-22", "has_results": true, "last_update_posted_date": "2025-11-14", "last_synced_at": "2026-06-11T06:01:57.203Z", "location_count": 1, "location_summary": "Chapel Hill, North Carolina", "locations": [ { "city": "Chapel Hill", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT06081283" }, { "nct_id": "NCT06510582", "title": "Chronic Subdural Hematoma Treatment With Intra-Arterial Bevacizumab Injection", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Chronic Subdural Hematoma" ], "interventions": [ { "name": "Bevacizumab 2 mg/kg", "type": "DRUG" }, { "name": "Bevacizumab 4 mg/kg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Cooper Health System", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 140, "start_date": "2024-06-17", "completion_date": "2028-06", "has_results": false, "last_update_posted_date": "2025-07-01", "last_synced_at": "2026-06-11T06:01:57.203Z", "location_count": 1, "location_summary": "Camden, New Jersey", "locations": [ { "city": "Camden", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT06510582" }, { "nct_id": "NCT03992404", "title": "Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury" ], "interventions": [ { "name": "NT 201", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merz Pharmaceuticals GmbH", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 603, "start_date": "2019-09-16", "completion_date": "2027-04", "has_results": false, "last_update_posted_date": "2026-05-22", "last_synced_at": "2026-06-11T06:01:57.203Z", "location_count": 15, "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Downey, California + 11 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Downey", "state": "California" }, { "city": "Stamford", "state": "Connecticut" }, { "city": "Brandenton", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03992404" }, { "nct_id": "NCT03496545", "title": "Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Subarachnoid Hemorrhage", "Subdural Hematoma", "Traumatic Brain Injury", "Ischemic Stroke", "Fever", "Intracerebral Hemorrhage" ], "interventions": [ { "name": "Bromocriptine 5 MG", "type": "DRUG" }, { "name": "Acetaminophen 650 MG", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, San Francisco", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 47, "start_date": "2018-11-30", "completion_date": "2019-11-02", "has_results": true, "last_update_posted_date": "2021-06-24", "last_synced_at": "2026-06-11T06:01:57.203Z", "location_count": 2, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03496545" }, { "nct_id": "NCT02652598", "title": "Evaluate the Effects of Tolcapone on Cognitive and Behavioral Dysfunction in Patients With BI and NCD", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Brain Injuries, Traumatic", "Neurocognitive Disorders", "Brain Injuries" ], "interventions": [ { "name": "Tolcapone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sheppard Pratt Health System", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 100, "start_date": "2015-11", "completion_date": null, "has_results": false, "last_update_posted_date": "2017-01-19", "last_synced_at": "2026-06-11T06:01:57.203Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02652598" }, { "nct_id": "NCT03353246", "title": "Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Head Trauma", "Craniocerebral Injuries", "Crushing Skull Injury", "Head Injuries", "Head Injuries, Multiple", "Head Injuries, Closed", "Head Trauma,Closed", "Head Trauma Injury", "Head Trauma, Penetrating", "Head Injury, Minor", "Head Injury Major", "Head Injury, Open", "Injuries, Craniocerebral", "Injuries, Head", "Multiple Head Injury", "Trauma, Head" ], "interventions": [ { "name": "InfraScanner 2000™", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 500, "start_date": "2017-12-11", "completion_date": "2018-05-04", "has_results": true, "last_update_posted_date": "2019-08-20", "last_synced_at": "2026-06-11T06:01:57.203Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT03353246" }, { "nct_id": "NCT00930202", "title": "Study of the Safety and Efficacy of Conivaptan (Vaprisol®) to Raise Serum Sodium Levels in Patients With Severe Traumatic Brain Injury", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Severe Traumatic Brain Injury" ], "interventions": [ { "name": "Conivaptan (Vaprisol)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Washington", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 10, "start_date": "2009-08", "completion_date": "2010-06", "has_results": false, "last_update_posted_date": "2010-09-10", "last_synced_at": "2026-06-11T06:01:57.203Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT00930202" } ] }