{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Head+Injury+Major&page=2",
    "query": {
      "condition": "Head Injury Major",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Head+Injury+Major&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-11T00:17:37.910Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00125229",
      "title": "Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Traumatic Brain Injury",
        "Intracranial Hypertension"
      ],
      "interventions": [
        {
          "name": "Mannitol",
          "type": "DRUG"
        },
        {
          "name": "Hypertonic Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 10,
      "start_date": "2005-08",
      "completion_date": "2006-06",
      "has_results": false,
      "last_update_posted_date": "2012-06-26",
      "last_synced_at": "2026-06-11T00:17:37.910Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00125229"
    },
    {
      "nct_id": "NCT05741411",
      "title": "Facilitating Access to Specialty Treatment",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mild Traumatic Brain Injury",
        "Concussion, Mild",
        "Concussion, Severe",
        "Concussion, Intermediate"
      ],
      "interventions": [
        {
          "name": "RPM-assisted specialist access",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "13 Years to 18 Years"
      },
      "enrollment_count": 210,
      "start_date": "2024-03-11",
      "completion_date": "2027-08-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-22",
      "last_synced_at": "2026-06-11T00:17:37.910Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05741411"
    },
    {
      "nct_id": "NCT03307070",
      "title": "Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Cognitive Behavioral Therapy for individuals with TBI",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Waitlist Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 62,
      "start_date": "2017-09-23",
      "completion_date": "2022-11-28",
      "has_results": false,
      "last_update_posted_date": "2023-04-10",
      "last_synced_at": "2026-06-11T00:17:37.910Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03307070"
    },
    {
      "nct_id": "NCT00113685",
      "title": "Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Distress Syndrome, Adult",
        "Head Injuries, Closed",
        "Shock",
        "Shock, Traumatic"
      ],
      "interventions": [
        {
          "name": "Hypertonic Saline-Dextran Solution",
          "type": "DRUG"
        },
        {
          "name": "Lactated Ringer's Solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 209,
      "start_date": "2003-04",
      "completion_date": "2007-03",
      "has_results": false,
      "last_update_posted_date": "2021-05-03",
      "last_synced_at": "2026-06-11T00:17:37.910Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00113685"
    },
    {
      "nct_id": "NCT05048966",
      "title": "Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury",
        "Mild Traumatic Brain Injury",
        "Alzheimer's Disease",
        "Brain Injury Traumatic Moderate",
        "Brain Injury Traumatic Severe",
        "Dementia"
      ],
      "interventions": [
        {
          "name": "Group Wellness Class 1",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Group Wellness Class 2",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Kessler Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 360,
      "start_date": "2022-12-08",
      "completion_date": "2025-09",
      "has_results": false,
      "last_update_posted_date": "2022-12-16",
      "last_synced_at": "2026-06-11T00:17:37.910Z",
      "location_count": 1,
      "location_summary": "East Hanover, New Jersey",
      "locations": [
        {
          "city": "East Hanover",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05048966"
    },
    {
      "nct_id": "NCT03353246",
      "title": "Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Head Trauma",
        "Craniocerebral Injuries",
        "Crushing Skull Injury",
        "Head Injuries",
        "Head Injuries, Multiple",
        "Head Injuries, Closed",
        "Head Trauma,Closed",
        "Head Trauma Injury",
        "Head Trauma, Penetrating",
        "Head Injury, Minor",
        "Head Injury Major",
        "Head Injury, Open",
        "Injuries, Craniocerebral",
        "Injuries, Head",
        "Multiple Head Injury",
        "Trauma, Head"
      ],
      "interventions": [
        {
          "name": "InfraScanner 2000™",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 500,
      "start_date": "2017-12-11",
      "completion_date": "2018-05-04",
      "has_results": true,
      "last_update_posted_date": "2019-08-20",
      "last_synced_at": "2026-06-11T00:17:37.910Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03353246"
    },
    {
      "nct_id": "NCT04079907",
      "title": "Ketone Supplementation in Adolescents Post-Concussion",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Concussion, Mild",
        "Concussion, Severe",
        "Concussion, Brain",
        "Concussive Injury",
        "Sport Injury",
        "Sports Injuries in Children"
      ],
      "interventions": [
        {
          "name": "Ketone",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "19 Years",
        "sex": "ALL",
        "summary": "13 Years to 19 Years"
      },
      "enrollment_count": 5,
      "start_date": "2020-03-20",
      "completion_date": "2022-04-27",
      "has_results": false,
      "last_update_posted_date": "2022-05-10",
      "last_synced_at": "2026-06-11T00:17:37.910Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04079907"
    },
    {
      "nct_id": "NCT02776462",
      "title": "Use of Eye Movement Tracking to Detect Oculomotor Abnormality in Traumatic Brain Injury Patients",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Brain Concussion",
        "Cerebral Concussion",
        "Concussion, Intermediate",
        "Concussion, Mild",
        "Concussion, Severe",
        "Trauma, Nervous System",
        "Craniocerebral Trauma",
        "Brain Injuries"
      ],
      "interventions": [
        {
          "name": "EyeBox CNS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Oculogica, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "67 Years",
        "sex": "ALL",
        "summary": "5 Years to 67 Years"
      },
      "enrollment_count": 321,
      "start_date": "2016-06",
      "completion_date": "2018-06-19",
      "has_results": false,
      "last_update_posted_date": "2018-09-07",
      "last_synced_at": "2026-06-11T00:17:37.910Z",
      "location_count": 2,
      "location_summary": "Lone Tree, Colorado • Beaver Dam, Wisconsin",
      "locations": [
        {
          "city": "Lone Tree",
          "state": "Colorado"
        },
        {
          "city": "Beaver Dam",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02776462"
    },
    {
      "nct_id": "NCT02957461",
      "title": "Validation of Brain Function Assessment Algorithm for mTBI/Concussion in College Athletes",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Brain Injuries, Traumatic",
        "Concussion, Mild",
        "Concussion, Brain",
        "Concussion, Severe",
        "Concussion, Intermediate"
      ],
      "interventions": [
        {
          "name": "BrainScope Ahead 200iD",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "BrainScope Company, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "18 Years to 25 Years"
      },
      "enrollment_count": 420,
      "start_date": "2017-02-03",
      "completion_date": "2018-03-02",
      "has_results": false,
      "last_update_posted_date": "2019-05-23",
      "last_synced_at": "2026-06-11T00:17:37.910Z",
      "location_count": 8,
      "location_summary": "Fayetteville, Arkansas • Storrs, Connecticut • Tampa, Florida + 5 more",
      "locations": [
        {
          "city": "Fayetteville",
          "state": "Arkansas"
        },
        {
          "city": "Storrs",
          "state": "Connecticut"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "East Lansing",
          "state": "Michigan"
        },
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02957461"
    },
    {
      "nct_id": "NCT04505293",
      "title": "Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Head Trauma",
        "Craniocerebral Injuries",
        "Crushing Skull Injury",
        "Head Injuries",
        "Head Injuries, Multiple",
        "Head Injuries, Closed",
        "Head Trauma,Closed",
        "Head Trauma Injury",
        "Head Trauma, Penetrating",
        "Head Injury, Minor",
        "Head Injury Major",
        "Head Injury, Open",
        "Injuries, Craniocerebral",
        "Injuries, Head",
        "Multiple Head Injury",
        "Trauma, Head"
      ],
      "interventions": [
        {
          "name": "InfraScanner 2000™",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 672,
      "start_date": "2021-10-05",
      "completion_date": "2022-08-05",
      "has_results": true,
      "last_update_posted_date": "2024-03-19",
      "last_synced_at": "2026-06-11T00:17:37.910Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04505293"
    }
  ]
}