{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Heart+Defect%2C+Congenital",
    "query": {
      "condition": "Heart Defect, Congenital"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 1097,
    "total_pages": 110,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Heart+Defect%2C+Congenital&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T09:14:13.296Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04956952",
      "title": "Enhanced External Counterpulsation in Patients With Fontan Circulation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Single-ventricle",
        "Congenital Heart Disease"
      ],
      "interventions": [
        {
          "name": "EECP",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 23,
      "start_date": "2022-03-31",
      "completion_date": "2023-05-17",
      "has_results": false,
      "last_update_posted_date": "2023-06-13",
      "last_synced_at": "2026-07-22T09:14:13.296Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04956952"
    },
    {
      "nct_id": "NCT05583721",
      "title": "Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Sickle Cell Disease"
      ],
      "interventions": [
        {
          "name": "[13N]NH3",
          "type": "DRUG"
        },
        {
          "name": "Lexiscan",
          "type": "DRUG"
        },
        {
          "name": "Positron emission tomography",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "St. Jude Children's Research Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "21 Years",
        "sex": "ALL",
        "summary": "18 Years to 21 Years"
      },
      "enrollment_count": 40,
      "start_date": "2023-10-10",
      "completion_date": "2028-09",
      "has_results": false,
      "last_update_posted_date": "2026-05-06",
      "last_synced_at": "2026-07-22T09:14:13.296Z",
      "location_count": 1,
      "location_summary": "Memphis, Tennessee",
      "locations": [
        {
          "city": "Memphis",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05583721"
    },
    {
      "nct_id": "NCT01330433",
      "title": "Effects of CoSeal on Bleeding & Adhesions in Pediatric Heart Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Congenital Heart Defect",
        "Surgery-Induced Tissue Adhesions",
        "Hemorrhage"
      ],
      "interventions": [
        {
          "name": "CoSeal Surgical Spray Group",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Loma Linda University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "Up to 17 Years"
      },
      "enrollment_count": 35,
      "start_date": "2011-08",
      "completion_date": "2015-08",
      "has_results": true,
      "last_update_posted_date": "2016-12-15",
      "last_synced_at": "2026-07-22T09:14:13.296Z",
      "location_count": 1,
      "location_summary": "Loma Linda, California",
      "locations": [
        {
          "city": "Loma Linda",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01330433"
    },
    {
      "nct_id": "NCT00283738",
      "title": "MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Migraine",
        "Aura",
        "Patent Foramen Ovale"
      ],
      "interventions": [
        {
          "name": "BioSTAR Septal Repair Implant System",
          "type": "DEVICE"
        },
        {
          "name": "Sham Procedure",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "NMT Medical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 610,
      "start_date": "2006-02",
      "completion_date": "2008-03",
      "has_results": false,
      "last_update_posted_date": "2008-01-25",
      "last_synced_at": "2026-07-22T09:14:13.296Z",
      "location_count": 2,
      "location_summary": "Stamford, Connecticut • Seattle, Washington",
      "locations": [
        {
          "city": "Stamford",
          "state": "Connecticut"
        },
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00283738"
    },
    {
      "nct_id": "NCT01929967",
      "title": "Defining Immunodeficiency in Heterotaxy Syndrome: Pilot Study Data",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Heterotaxy Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "Up to 12 Years"
      },
      "enrollment_count": 10,
      "start_date": "2013-08",
      "completion_date": "2014-06",
      "has_results": false,
      "last_update_posted_date": "2014-06-27",
      "last_synced_at": "2026-07-22T09:14:13.296Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01929967"
    },
    {
      "nct_id": "NCT02498444",
      "title": "Perioperative Treprostinil in Pediatric Patients Undergoing the Fontan Operation",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Single Ventricle"
      ],
      "interventions": [
        {
          "name": "Treprostinil",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "1 Year to 18 Years"
      },
      "enrollment_count": 34,
      "start_date": "2015-09",
      "completion_date": "2020-12",
      "has_results": true,
      "last_update_posted_date": "2022-03-31",
      "last_synced_at": "2026-07-22T09:14:13.296Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02498444"
    },
    {
      "nct_id": "NCT01461304",
      "title": "Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism",
      "overall_status": "NO_LONGER_AVAILABLE",
      "study_type": "EXPANDED_ACCESS",
      "phases": [],
      "conditions": [
        "Very Long-chain acylCoA Dehydrogenase (VLCAD) Deficiency",
        "Carnitine Palmitoyltransferase Deficiencies (CPT1, CPT2)",
        "Mitochondrial Trifunctional Protein Deficiency",
        "Long-chain Hydroxyacyl-CoA Dehydrogenase Deficiency",
        "Glycogen Storage Disorders",
        "Pyruvate Carboxylase Deficiency Disease",
        "ACYL-CoA DEHYDROGENASE FAMILY, MEMBER 9, DEFICIENCY of",
        "Barth Syndrome"
      ],
      "interventions": [
        {
          "name": "triheptanoin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Jerry Vockley, MD, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Month",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "1 Month and older"
      },
      "enrollment_count": null,
      "start_date": null,
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2021-12-10",
      "last_synced_at": "2026-07-22T09:14:13.296Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01461304"
    },
    {
      "nct_id": "NCT05980104",
      "title": "Single-Session \"Empowered Relief\" Class for Marfan Syndrome and Related Conditions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Pain",
        "Marfan Syndrome",
        "Vascular Ehlers-Danlos Syndrome",
        "Loeys-Dietz Syndrome"
      ],
      "interventions": [
        {
          "name": "Empowered Relief",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 92,
      "start_date": "2024-03-21",
      "completion_date": "2024-08-31",
      "has_results": false,
      "last_update_posted_date": "2024-10-26",
      "last_synced_at": "2026-07-22T09:14:13.296Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05980104"
    },
    {
      "nct_id": "NCT03481985",
      "title": "The Effect of Fontan Fenestration Closure on Hepatic Stiffness",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Single-ventricle",
        "Hepatic Congestion"
      ],
      "interventions": [
        {
          "name": "Fenestration status",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 16,
      "start_date": "2018-05-29",
      "completion_date": "2022-06-30",
      "has_results": false,
      "last_update_posted_date": "2023-04-19",
      "last_synced_at": "2026-07-22T09:14:13.296Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03481985"
    },
    {
      "nct_id": "NCT03882450",
      "title": "Universal Screening for Vocal Fold Motion Impairment in Children Undergoing Congenital Cardiac Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Vocal Fold Palsy",
        "Dysphagia",
        "Congenital Heart Disease in Children"
      ],
      "interventions": [
        {
          "name": "Flexible fiberoptic laryngoscopy",
          "type": "PROCEDURE"
        },
        {
          "name": "Laryngeal ultrasonography",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "Up to 18 Years"
      },
      "enrollment_count": 94,
      "start_date": "2019-01-01",
      "completion_date": "2020-03-13",
      "has_results": false,
      "last_update_posted_date": "2020-04-14",
      "last_synced_at": "2026-07-22T09:14:13.296Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03882450"
    }
  ]
}