{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Heart+Failure+NYHA+Class+III&page=2",
    "query": {
      "condition": "Heart Failure NYHA Class III",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Heart+Failure+NYHA+Class+III&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T21:39:25.945Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03005184",
      "title": "Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Heart Failure NYHA Class I",
        "Heart Failure NYHA Class II",
        "Heart Failure NYHA Class III"
      ],
      "interventions": [
        {
          "name": "Valsartan 80 mg bid",
          "type": "DRUG"
        },
        {
          "name": "Enalapril 10 mg bid",
          "type": "DRUG"
        },
        {
          "name": "Sacubitril-Valsartan 200 mg bid",
          "type": "DRUG"
        },
        {
          "name": "Icatibant",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 0,
      "start_date": "2017-09",
      "completion_date": "2020-01",
      "has_results": false,
      "last_update_posted_date": "2018-01-11",
      "last_synced_at": "2026-06-26T21:39:25.945Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03005184"
    },
    {
      "nct_id": "NCT00283361",
      "title": "ZP120 Add-on to Furosemide in Treatment of Acute or Sub-Acute Decompensated Heart Failure",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Heart Failure, Congestive"
      ],
      "interventions": [
        {
          "name": "ZP120",
          "type": "DRUG"
        },
        {
          "name": "I.v. catherization",
          "type": "PROCEDURE"
        },
        {
          "name": "6-minutes walk performance",
          "type": "PROCEDURE"
        },
        {
          "name": "Dyspnea severity assessment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Blood sampling for laboratory tests",
          "type": "PROCEDURE"
        },
        {
          "name": "ECG",
          "type": "PROCEDURE"
        },
        {
          "name": "Physical examination",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE",
        "BEHAVIORAL"
      ],
      "sponsor": "Zealand Pharma",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 130,
      "start_date": "2006-01",
      "completion_date": "2006-12",
      "has_results": false,
      "last_update_posted_date": "2007-02-28",
      "last_synced_at": "2026-06-26T21:39:25.945Z",
      "location_count": 22,
      "location_summary": "Los Angeles, California • San Diego, California • San Francisco, California + 17 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00283361"
    },
    {
      "nct_id": "NCT01381172",
      "title": "Evaluate Safety and Efficacy of the OPTIMIZER® System in Subjects With Moderate-to-Severe Heart Failure: FIX-HF-5C",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "NYHA Class III Heart Failure",
        "NYHA Class IV Heart Failure"
      ],
      "interventions": [
        {
          "name": "Optimizer System",
          "type": "DEVICE"
        },
        {
          "name": "No intervention: Optimal medical therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Impulse Dynamics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 160,
      "start_date": "2011-01",
      "completion_date": "2019-03-19",
      "has_results": true,
      "last_update_posted_date": "2021-09-17",
      "last_synced_at": "2026-06-26T21:39:25.945Z",
      "location_count": 32,
      "location_summary": "Glendale, Arizona • Mesa, Arizona • Phoenix, Arizona + 26 more",
      "locations": [
        {
          "city": "Glendale",
          "state": "Arizona"
        },
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01381172"
    },
    {
      "nct_id": "NCT00007683",
      "title": "Warfarin and Antiplatelet Therapy in Chronic Heart Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Heart Failure"
      ],
      "interventions": [
        {
          "name": "Warfarin titrated to an INR of 2.5-3.0",
          "type": "DRUG"
        },
        {
          "name": "Aspirin",
          "type": "DRUG"
        },
        {
          "name": "Clopidogrel 75",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "US Department of Veterans Affairs",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1587,
      "start_date": "1998-10",
      "completion_date": "2004-12",
      "has_results": false,
      "last_update_posted_date": "2011-06-16",
      "last_synced_at": "2026-06-26T21:39:25.945Z",
      "location_count": 79,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 76 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "No. Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Downey",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00007683"
    },
    {
      "nct_id": "NCT07646210",
      "title": "HiCM-188 Cell Therapy in Adults With Advanced Heart Failure Undergoing Heart Bypass Surgery",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Advanced Heart Failure",
        "Ischemic Heart Failure"
      ],
      "interventions": [
        {
          "name": "HiCM-188 Cells",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HELP Therapeutics Co., Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 12,
      "start_date": "2026-09",
      "completion_date": "2028-05",
      "has_results": false,
      "last_update_posted_date": "2026-06-12",
      "last_synced_at": "2026-06-26T21:39:25.945Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07646210"
    },
    {
      "nct_id": "NCT02939053",
      "title": "Correlation of SOZO BIS Measures With CardioMEMS PA Pressure",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "NYHA Class III Heart Failure"
      ],
      "interventions": [
        {
          "name": "SOZO",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "ImpediMed Limited",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 3,
      "start_date": "2017-08-29",
      "completion_date": "2019-06-25",
      "has_results": false,
      "last_update_posted_date": "2019-07-08",
      "last_synced_at": "2026-06-26T21:39:25.945Z",
      "location_count": 2,
      "location_summary": "Rochester, Minnesota • Lancaster, Pennsylvania",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Lancaster",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02939053"
    },
    {
      "nct_id": "NCT07209098",
      "title": "Propensity-Matched Study of Cardiac Contractility Modulation Therapy in Heart Failure",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Heart Failure and Reduced Ejection Fraction",
        "NYHA Class III Heart Failure"
      ],
      "interventions": [
        {
          "name": "Cardiac Contractility Modulation (CCM)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Impulse Dynamics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4200,
      "start_date": "2025-11-18",
      "completion_date": "2031-04",
      "has_results": false,
      "last_update_posted_date": "2026-03-24",
      "last_synced_at": "2026-06-26T21:39:25.945Z",
      "location_count": 1,
      "location_summary": "Marlton, New Jersey",
      "locations": [
        {
          "city": "Marlton",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07209098"
    },
    {
      "nct_id": "NCT01369407",
      "title": "REGISTRY EVALUATION OF VITAL INFORMATION FOR VADs IN AMBULATORY LIFE",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Congestive Heart Failure"
      ],
      "interventions": [
        {
          "name": "No Intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 400,
      "start_date": "2015-07",
      "completion_date": "2018-08-29",
      "has_results": false,
      "last_update_posted_date": "2018-09-07",
      "last_synced_at": "2026-06-26T21:39:25.945Z",
      "location_count": 21,
      "location_summary": "Birmingham, Alabama • Beverly Hills, California • Aurora, Colorado + 17 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01369407"
    },
    {
      "nct_id": "NCT00578695",
      "title": "THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Hyponatremia"
      ],
      "interventions": [
        {
          "name": "lixivaptan",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "CardioKine Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 652,
      "start_date": "2007-01",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2011-06-28",
      "last_synced_at": "2026-06-26T21:39:25.945Z",
      "location_count": 102,
      "location_summary": "Birmingham, Alabama • Mobile, Alabama • Bakersfield, California + 82 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Bakersfield",
          "state": "California"
        },
        {
          "city": "Banning",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00578695"
    },
    {
      "nct_id": "NCT03387813",
      "title": "Hemodynamic-GUIDEd Management of Heart Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Heart Failure",
        "Heart Failure, Systolic",
        "Heart Failure, Diastolic",
        "Heart Failure NYHA Class II",
        "Heart Failure NYHA Class III",
        "Heart Failure NYHA Class IV",
        "Heart Failure，Congestive",
        "Heart Failure With Reduced Ejection Fraction",
        "Heart Failure With Normal Ejection Fraction",
        "Heart Failure; With Decompensation"
      ],
      "interventions": [
        {
          "name": "CardioMEMS™ HF System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2358,
      "start_date": "2018-03-15",
      "completion_date": "2023-05-17",
      "has_results": true,
      "last_update_posted_date": "2025-08-07",
      "last_synced_at": "2026-06-26T21:39:25.945Z",
      "location_count": 125,
      "location_summary": "Phoenix, Arizona • Tucson, Arizona • Fayetteville, Arkansas + 100 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Fayetteville",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03387813"
    }
  ]
}