{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Heart+Valve+Prosthesis",
    "query": {
      "condition": "Heart Valve Prosthesis"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 16,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Heart+Valve+Prosthesis&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-11T04:52:39.206Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01635244",
      "title": "Hemodynamic Comparison of Tissue Aortic Valves",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Valve Stenosis"
      ],
      "interventions": [
        {
          "name": "Aortic valve replacement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2012-07",
      "completion_date": "2015-12",
      "has_results": true,
      "last_update_posted_date": "2017-02-03",
      "last_synced_at": "2026-06-11T04:52:39.206Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01635244"
    },
    {
      "nct_id": "NCT01334801",
      "title": "Biomarkers in Aortic Stenosis - B.A.S.S.",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Aortic Stenosis",
        "Disorder of Prosthetic Cardiac Valve",
        "Aortic Valve Insufficiency",
        "Mitral Valve Insufficiency",
        "Hypertrophic Cardiomyopathy",
        "Tricuspid Valve Insufficiency"
      ],
      "interventions": [
        {
          "name": "Blood Draw",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 378,
      "start_date": "2010-07",
      "completion_date": "2020-01-31",
      "has_results": false,
      "last_update_posted_date": "2022-05-05",
      "last_synced_at": "2026-06-11T04:52:39.206Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01334801"
    },
    {
      "nct_id": "NCT05236153",
      "title": "Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tetralogy of Fallot",
        "Ventricular Tachycardia",
        "Sudden Cardiac Death"
      ],
      "interventions": [
        {
          "name": "Electroanatomic substrate mapping",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 60,
      "start_date": "2022-11-04",
      "completion_date": "2024-01-01",
      "has_results": false,
      "last_update_posted_date": "2023-02-08",
      "last_synced_at": "2026-06-11T04:52:39.206Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05236153"
    },
    {
      "nct_id": "NCT05459233",
      "title": "Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Valve Stenosis",
        "Aortic Valve Regurgitation",
        "Prosthesis Failure"
      ],
      "interventions": [
        {
          "name": "Doppler-echocardiography",
          "type": "PROCEDURE"
        },
        {
          "name": "Invasive hemodynamic measurements",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Institut universitaire de cardiologie et de pneumologie de Québec, University Laval",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 310,
      "start_date": "2023-01-11",
      "completion_date": "2029-09-01",
      "has_results": false,
      "last_update_posted_date": "2026-03-24",
      "last_synced_at": "2026-06-11T04:52:39.206Z",
      "location_count": 6,
      "location_summary": "San Francisco, California • Hollywood, Florida • Royal Oak, Michigan + 3 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Hollywood",
          "state": "Florida"
        },
        {
          "city": "Royal Oak",
          "state": "Michigan"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Syracuse",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05459233"
    },
    {
      "nct_id": "NCT00291525",
      "title": "Randomized On-X Anticoagulation Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Heart Valve Disease"
      ],
      "interventions": [
        {
          "name": "On-X valve using reduced anticoagulation",
          "type": "DEVICE"
        },
        {
          "name": "On-X Valve with Standard warfarin Therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "On-X Life Technologies, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 977,
      "start_date": "2006-06-06",
      "completion_date": "2023-12-29",
      "has_results": true,
      "last_update_posted_date": "2024-12-24",
      "last_synced_at": "2026-06-11T04:52:39.206Z",
      "location_count": 44,
      "location_summary": "Tucson, Arizona • Loma Linda, California • Hartford, Connecticut + 34 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "Hartford",
          "state": "Connecticut"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00291525"
    },
    {
      "nct_id": "NCT02677974",
      "title": "On-X Aortic Prosthetic Heart Valve Low Dose Warfarin Post Approval Clinical Registry Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Thrombotic and Bleeding Events"
      ],
      "interventions": [
        {
          "name": "On-X Aortic Heart Valve replacement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "On-X Life Technologies, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 510,
      "start_date": "2015-11-10",
      "completion_date": "2027-08",
      "has_results": false,
      "last_update_posted_date": "2024-10-08",
      "last_synced_at": "2026-06-11T04:52:39.206Z",
      "location_count": 15,
      "location_summary": "Tucson, Arizona • Hartford, Connecticut • Indianapolis, Indiana + 12 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Hartford",
          "state": "Connecticut"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Portland",
          "state": "Maine"
        },
        {
          "city": "Fargo",
          "state": "North Dakota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02677974"
    },
    {
      "nct_id": "NCT00691470",
      "title": "Comparison of ATI-5923, a Novel Vitamin K Antagonist, With Warfarin in Patients Requiring Chronic Anticoagulation",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Atrial Fibrillation",
        "Atrial Flutter",
        "Venous Thromboembolic Disease",
        "Myocardial Infarction",
        "Cardiomyopathy"
      ],
      "interventions": [
        {
          "name": "ATI-5923",
          "type": "DRUG"
        },
        {
          "name": "Coumadin (warfarin)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "ARYx Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 600,
      "start_date": "2008-05",
      "completion_date": "2009-06",
      "has_results": false,
      "last_update_posted_date": "2010-02-02",
      "last_synced_at": "2026-06-11T04:52:39.206Z",
      "location_count": 41,
      "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 34 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Huntsville",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00691470"
    },
    {
      "nct_id": "NCT00107666",
      "title": "CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Coronary Disease",
        "Heart Valve Diseases"
      ],
      "interventions": [
        {
          "name": "CTI-01 (ethyl pyruvate)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Critical Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2005-04",
      "completion_date": "2006-04",
      "has_results": false,
      "last_update_posted_date": "2006-03-17",
      "last_synced_at": "2026-06-11T04:52:39.206Z",
      "location_count": 17,
      "location_summary": "Laguna Hills, California • Los Angeles, California • San Francisco, California + 14 more",
      "locations": [
        {
          "city": "Laguna Hills",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00107666"
    },
    {
      "nct_id": "NCT00904982",
      "title": "Randomized Trial of Interventions to Improve Warfarin Adherence",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Atrial Fibrillation",
        "Deep Vein Thrombosis",
        "Dilated Cardiomyopathies"
      ],
      "interventions": [
        {
          "name": "Financial Incentive and Med-eMonitor",
          "type": "BEHAVIORAL"
        },
        {
          "name": "2Med-eMonitor",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DEVICE"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 268,
      "start_date": "2009-10",
      "completion_date": "2013-12",
      "has_results": true,
      "last_update_posted_date": "2017-03-16",
      "last_synced_at": "2026-06-11T04:52:39.206Z",
      "location_count": 2,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00904982"
    },
    {
      "nct_id": "NCT04372381",
      "title": "Supra-Annular vs. Annular ValvEs for Small Annuli",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Valve Stenosis",
        "Implantation, Heart Valve Prosthesis"
      ],
      "interventions": [
        {
          "name": "Transcatheter aortic valve replacement (Edwards Sapien Ultra or Medtronic Evolut Pro",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Marvin Eng",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 150,
      "start_date": "2020-05-12",
      "completion_date": "2025-06",
      "has_results": false,
      "last_update_posted_date": "2023-01-27",
      "last_synced_at": "2026-06-11T04:52:39.206Z",
      "location_count": 3,
      "location_summary": "Phoenix, Arizona • Tucson, Arizona • Delray Beach, Florida",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Delray Beach",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04372381"
    }
  ]
}