{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Heart+Valve+Replacement&page=2",
    "query": {
      "condition": "Heart Valve Replacement",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Heart+Valve+Replacement&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T13:57:52.566Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07130994",
      "title": "Reduction of Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US)",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Regurgitation",
        "Heart Disease"
      ],
      "interventions": [
        {
          "name": "Mitral Valve Replacement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "InnovHeart",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2026-06",
      "completion_date": "2032-01",
      "has_results": false,
      "last_update_posted_date": "2026-06-02",
      "last_synced_at": "2026-07-22T13:57:52.566Z",
      "location_count": 5,
      "location_summary": "Los Angeles, California • Sacramento, California • Thousand Oaks, California + 2 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Thousand Oaks",
          "state": "California"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07130994"
    },
    {
      "nct_id": "NCT05189886",
      "title": "Transcatheter Aortic Valve Replacement (TAVR) Double Balloon Valvuloplasty",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Aortic Valve Stenosis"
      ],
      "interventions": [
        {
          "name": "Double Balloon Valvuloplasty in TAVR",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Community Memorial Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 400,
      "start_date": "2021-11-10",
      "completion_date": "2024-12",
      "has_results": false,
      "last_update_posted_date": "2022-01-13",
      "last_synced_at": "2026-07-22T13:57:52.566Z",
      "location_count": 1,
      "location_summary": "Ventura, California",
      "locations": [
        {
          "city": "Ventura",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05189886"
    },
    {
      "nct_id": "NCT02718001",
      "title": "Edwards EVOQUE Eos MISCEND Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Valve Regurgitation (Degenerative or Functional)"
      ],
      "interventions": [
        {
          "name": "Edwards EVOQUE Eos Mitral Valve Replacement System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Edwards Lifesciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 123,
      "start_date": "2015-02-06",
      "completion_date": "2033-04-30",
      "has_results": false,
      "last_update_posted_date": "2026-04-13",
      "last_synced_at": "2026-07-22T13:57:52.566Z",
      "location_count": 16,
      "location_summary": "Burlingame, California • Los Angeles, California • San Francisco, California + 13 more",
      "locations": [
        {
          "city": "Burlingame",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02718001"
    },
    {
      "nct_id": "NCT06689839",
      "title": "Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Stenosis Treated With TAVI",
        "Aortic Diseases"
      ],
      "interventions": [
        {
          "name": "F2 Filter and Delivery System",
          "type": "DEVICE"
        },
        {
          "name": "Transcatheter Aortic Valve Replacement (TAVR)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "EnCompass Technologies, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 500,
      "start_date": "2025-09-09",
      "completion_date": "2027-01",
      "has_results": false,
      "last_update_posted_date": "2025-11-20",
      "last_synced_at": "2026-07-22T13:57:52.566Z",
      "location_count": 8,
      "location_summary": "Naples, Florida • Indianappolis, Indiana • Detroit, Michigan + 5 more",
      "locations": [
        {
          "city": "Naples",
          "state": "Florida"
        },
        {
          "city": "Indianappolis",
          "state": "Indiana"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "Kansas City",
          "state": "Missouri"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06689839"
    },
    {
      "nct_id": "NCT05372757",
      "title": "Partial Heart Transplantation for Severe Pediatric Semilunar Valve Dysfunction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Semilunar Heart Valve Replacement"
      ],
      "interventions": [
        {
          "name": "Partial Heart Transplantation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "2 Years",
        "sex": "ALL",
        "summary": "1 Day to 2 Years"
      },
      "enrollment_count": 5,
      "start_date": "2023-05-03",
      "completion_date": "2023-11-30",
      "has_results": false,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-07-22T13:57:52.566Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05372757"
    },
    {
      "nct_id": "NCT01171625",
      "title": "Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Coronary Artery Disease",
        "Aortic Valve Disorder",
        "Heart Failure",
        "Aortic Valve Stenosis",
        "Aortic Valve Insufficiency"
      ],
      "interventions": [
        {
          "name": "Implantation of CEP Magna Ease Model 3300TFX",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Edwards Lifesciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 283,
      "start_date": "2007-10",
      "completion_date": "2018-09",
      "has_results": true,
      "last_update_posted_date": "2020-04-17",
      "last_synced_at": "2026-07-22T13:57:52.566Z",
      "location_count": 5,
      "location_summary": "Sacramento, California • Camden, New Jersey • Morristown, New Jersey + 2 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Camden",
          "state": "New Jersey"
        },
        {
          "city": "Morristown",
          "state": "New Jersey"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01171625"
    },
    {
      "nct_id": "NCT05075590",
      "title": "Coronary Access After Supra-Annular THV Implantation",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Coronary Angiography",
        "Transcatheter Aortic Valve Replacement"
      ],
      "interventions": [
        {
          "name": "Coronary Angiography",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of British Columbia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2021-10-27",
      "completion_date": "2024-07-31",
      "has_results": false,
      "last_update_posted_date": "2023-12-20",
      "last_synced_at": "2026-07-22T13:57:52.566Z",
      "location_count": 1,
      "location_summary": "Harrisburg, Pennsylvania",
      "locations": [
        {
          "city": "Harrisburg",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05075590"
    },
    {
      "nct_id": "NCT06680427",
      "title": "Siegel™ Transcatheter Aortic Valve Replacement System (TAVR) Early Feasibility Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Stenosis Symptomatic"
      ],
      "interventions": [
        {
          "name": "Siegel Transcatheter Aortic Valve (TAVR)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "MiRus",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2025-03-26",
      "completion_date": "2025-12",
      "has_results": false,
      "last_update_posted_date": "2025-12-03",
      "last_synced_at": "2026-07-22T13:57:52.566Z",
      "location_count": 8,
      "location_summary": "Los Angeles, California • Palo Alto, California • Naples, Florida + 5 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Naples",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06680427"
    },
    {
      "nct_id": "NCT03557242",
      "title": "Strategies to Prevent Transcatheter Heart Valve Dysfunction in Low Risk Transcatheter Aortic Valve Replacement",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Stenosis"
      ],
      "interventions": [
        {
          "name": "TAVR",
          "type": "DEVICE"
        },
        {
          "name": "Warfarin plus Aspirin",
          "type": "OTHER"
        },
        {
          "name": "Aspirin Only",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Medstar Health Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 124,
      "start_date": "2018-07-05",
      "completion_date": "2023-07-30",
      "has_results": false,
      "last_update_posted_date": "2022-01-04",
      "last_synced_at": "2026-07-22T13:57:52.566Z",
      "location_count": 7,
      "location_summary": "San Diego, California • Washington D.C., District of Columbia • Ridgewood, New Jersey + 4 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Ridgewood",
          "state": "New Jersey"
        },
        {
          "city": "Stony Brook",
          "state": "New York"
        },
        {
          "city": "Tulsa",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03557242"
    },
    {
      "nct_id": "NCT03836521",
      "title": "Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Bicuspid Aortic Valve"
      ],
      "interventions": [
        {
          "name": "Transcatheter aortic valve replacement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "129 Years",
        "sex": "ALL",
        "summary": "19 Years to 129 Years"
      },
      "enrollment_count": 2000,
      "start_date": "2016-08-15",
      "completion_date": "2028-08-15",
      "has_results": false,
      "last_update_posted_date": "2019-02-11",
      "last_synced_at": "2026-07-22T13:57:52.566Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03836521"
    }
  ]
}