{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hepatic%3B+Functional+Disturbance&page=2", "query": { "condition": "Hepatic; Functional Disturbance", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hepatic%3B+Functional+Disturbance&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-07-23T21:56:40.660Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00091117", "title": "Bortezomib in Treating Patients With Advanced Cancer and Liver Dysfunction", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hepatic Complications", "Malignant Neoplasm" ], "interventions": [ { "name": "bortezomib", "type": "DRUG" }, { "name": "pharmacological study", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "National Cancer Institute (NCI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 80, "start_date": "2004-07", "completion_date": null, "has_results": false, "last_update_posted_date": "2013-12-16", "last_synced_at": "2026-07-23T21:56:40.660Z", "location_count": 3, "location_summary": "Duarte, California • Baltimore, Maryland • Detroit, Michigan", "locations": [ { "city": "Duarte", "state": "California" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Detroit", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT00091117" }, { "nct_id": "NCT00141284", "title": "An Open Label Study To Evaluate The Safety and Kinetics of Nelfinavir in Subjects With HIV and Hepatitis C", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "HIV Infection", "Hepatitis C" ], "interventions": [ { "name": "nelfinavir 1,250 mg twice daily", "type": "DRUG" }, { "name": "Zidovudine 300 mg twice daily", "type": "DRUG" }, { "name": "Lamivudine 150 mg twice daily", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 12, "start_date": "2005-10", "completion_date": "2006-12", "has_results": false, "last_update_posted_date": "2011-05-16", "last_synced_at": "2026-07-23T21:56:40.660Z", "location_count": 4, "location_summary": "Bakersfield, California • Miami, Florida • Shreveport, Louisiana + 1 more", "locations": [ { "city": "Bakersfield", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "Shreveport", "state": "Louisiana" }, { "city": "Dallas", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00141284" }, { "nct_id": "NCT00145041", "title": "Pharmacokinetic Study of Liposomal Vincristine in Patients With Malignant Melanoma & Hepatic Dysfunction", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malignant Melanoma" ], "interventions": [ { "name": "Vincristine Sulfate Liposomes Injection", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Acrotech Biopharma Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 7, "start_date": "2005-02", "completion_date": "2007-11", "has_results": true, "last_update_posted_date": "2019-12-12", "last_synced_at": "2026-07-23T21:56:40.660Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00145041" }, { "nct_id": "NCT05195125", "title": "Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "End Stage Liver DIsease", "Obesity", "Acute Kidney Injury" ], "interventions": [ { "name": "Direct Peritoneal Resuscitation", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "University of Colorado, Denver", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 15, "start_date": "2022-02-01", "completion_date": "2023-12", "has_results": false, "last_update_posted_date": "2023-06-08", "last_synced_at": "2026-07-23T21:56:40.660Z", "location_count": 1, "location_summary": "Aurora, Colorado", "locations": [ { "city": "Aurora", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT05195125" }, { "nct_id": "NCT03151798", "title": "The Liver Health Study for Patients with NAFLD", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Nonalcoholic Fatty Liver", "Nonalcoholic Steatohepatitis", "Obesity" ], "interventions": [ { "name": "Phase II: Lifestyle treatment", "type": "BEHAVIORAL" }, { "name": "Phase II: Control treatment", "type": "BEHAVIORAL" }, { "name": "Phase I: Observational studies", "type": "OTHER" } ], "intervention_types": [ "BEHAVIORAL", "OTHER" ], "sponsor": "University of Missouri-Columbia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "22 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "22 Years to 65 Years" }, "enrollment_count": 336, "start_date": "2017-08-09", "completion_date": "2023-04-29", "has_results": false, "last_update_posted_date": "2024-12-19", "last_synced_at": "2026-07-23T21:56:40.660Z", "location_count": 1, "location_summary": "Columbia, Missouri", "locations": [ { "city": "Columbia", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT03151798" }, { "nct_id": "NCT05900050", "title": "Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)®", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Acute-On-Chronic Liver Failure", "Ascites" ], "interventions": [ { "name": "VS-01 on top of SOC", "type": "DRUG" }, { "name": "SOC (Control Group)", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Genfit", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "79 Years", "sex": "ALL", "summary": "18 Years to 79 Years" }, "enrollment_count": 15, "start_date": "2023-07-02", "completion_date": "2025-10-15", "has_results": true, "last_update_posted_date": "2026-07-23", "last_synced_at": "2026-07-23T21:56:40.660Z", "location_count": 13, "location_summary": "Sacramento, California • Washington D.C., District of Columbia • Tampa, Florida + 9 more", "locations": [ { "city": "Sacramento", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Tampa", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT05900050" }, { "nct_id": "NCT00275093", "title": "Temsirolimus in Treating Patients With Metastatic Solid Tumor or Lymphoma That Cannot Be Removed By Surgery Who Have Different Levels of Liver Function", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hepatic Complications", "Lymphoma", "Unspecified Adult Solid Tumor, Protocol Specific" ], "interventions": [ { "name": "temsirolimus", "type": "DRUG" }, { "name": "laboratory biomarker analysis", "type": "OTHER" }, { "name": "pharmacological study", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "National Cancer Institute (NCI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 130, "start_date": "2005-12", "completion_date": null, "has_results": false, "last_update_posted_date": "2013-01-30", "last_synced_at": "2026-07-23T21:56:40.660Z", "location_count": 1, "location_summary": "San Antonio, Texas", "locations": [ { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00275093" }, { "nct_id": "NCT01392807", "title": "Open-label Study to Assess the Pharmacokinetics of NKTR-118 in Patients With Impaired Hepatic Function", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hepatic; Functional Disturbance" ], "interventions": [ { "name": "NKTR-118", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 24, "start_date": "2011-07", "completion_date": "2011-11", "has_results": false, "last_update_posted_date": "2014-10-15", "last_synced_at": "2026-07-23T21:56:40.660Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01392807" }, { "nct_id": "NCT05478603", "title": "A Study to Understand How the Study Medicine (PF-07081532) is Processed in People With Liver Dysfunction", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hepatic Impairment", "Healthy Volunteers" ], "interventions": [ { "name": "PF-07081532", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 24, "start_date": "2022-08-01", "completion_date": "2023-04-05", "has_results": true, "last_update_posted_date": "2024-08-22", "last_synced_at": "2026-07-23T21:56:40.660Z", "location_count": 2, "location_summary": "Orlando, Florida • Tampa, Florida", "locations": [ { "city": "Orlando", "state": "Florida" }, { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05478603" }, { "nct_id": "NCT07058155", "title": "Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Liver Cirrhoses", "Portal Hypertension Related to Cirrhosis", "Severe Obesity", "TIPS" ], "interventions": [ { "name": "Transjugular Intrahepatic Portosystemic Shunt (TIPS)", "type": "PROCEDURE" }, { "name": "Sleeve Gastrectomy", "type": "PROCEDURE" }, { "name": "Anti-Obesity Pharmacotherapy (Class Effect)", "type": "DRUG" }, { "name": "Lifestyle Counseling - Diet & Physical-Activity Program", "type": "BEHAVIORAL" } ], "intervention_types": [ "PROCEDURE", "DRUG", "BEHAVIORAL" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 70, "start_date": "2025-12-17", "completion_date": "2034-02-01", "has_results": false, "last_update_posted_date": "2025-12-23", "last_synced_at": "2026-07-23T21:56:40.660Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT07058155" } ] }