{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hereditary+Angioedema", "query": { "condition": "Hereditary Angioedema" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 87, "total_pages": 9, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hereditary+Angioedema&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-06-10T14:01:15.965Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00432510", "title": "Pharmacokinetics of C1 Esterase Inhibitor in Hereditary Angioedema Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "C1 esterase inhibitor [human] (C1INH-nf)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 27, "start_date": "2006-10-09", "completion_date": "2007-02-28", "has_results": false, "last_update_posted_date": "2021-06-03", "last_synced_at": "2026-06-10T14:01:15.965Z", "location_count": 6, "location_summary": "San Diego, California • Walnut Creek, California • Atlanta, Georgia + 3 more", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Wheaton", "state": "Maryland" }, { "city": "Hershey", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00432510" }, { "nct_id": "NCT03485911", "title": "Efficacy and Safety Study of BCX7353 as an Oral Treatment for the Prevention of Attacks in HAE", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema", "HAE" ], "interventions": [ { "name": "BCX7353 capsules", "type": "DRUG" }, { "name": "Placebo oral capsule", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "BioCryst Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 121, "start_date": "2018-02-06", "completion_date": "2022-04-06", "has_results": true, "last_update_posted_date": "2023-06-26", "last_synced_at": "2026-06-10T14:01:15.965Z", "location_count": 27, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 24 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03485911" }, { "nct_id": "NCT05047185", "title": "Dose-ranging Study of Oral PHA-022121 for Prophylaxis Against Angioedema Attacks in Patients With Hereditary Angioedema Type I or Type II", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hereditary Angioedema", "Hereditary Angioedema Type I", "Hereditary Angioedema Type II", "Hereditary Angioedema Types I and II", "Hereditary Angioedema Attack", "Hereditary Angioedema With C1 Esterase Inhibitor Deficiency", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2", "C1 Esterase Inhibitor Deficiency", "C1 Inhibitor Deficiency" ], "interventions": [ { "name": "Deucrictibant low dose", "type": "DRUG" }, { "name": "Deucrictibant high dose", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pharvaris Netherlands B.V.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 34, "start_date": "2022-04-19", "completion_date": "2025-06-30", "has_results": false, "last_update_posted_date": "2025-07-30", "last_synced_at": "2026-06-10T14:01:15.965Z", "location_count": 3, "location_summary": "Birmingham, Alabama • Paradise Valley, Arizona • St Louis, Missouri", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Paradise Valley", "state": "Arizona" }, { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT05047185" }, { "nct_id": "NCT05121376", "title": "A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Hereditary Angioedema", "HAE" ], "interventions": [ { "name": "Dose 1 of BMN 331", "type": "GENETIC" }, { "name": "Dose 2 of BMN 331", "type": "GENETIC" }, { "name": "Dose 3 of BMN 331", "type": "GENETIC" }, { "name": "Dose 4 of BMN 331", "type": "GENETIC" }, { "name": "Dose 5 of BMN 331", "type": "GENETIC" }, { "name": "Dose 6 of BMN 331", "type": "GENETIC" }, { "name": "Dose 7 of BMN 331", "type": "GENETIC" } ], "intervention_types": [ "GENETIC" ], "sponsor": "BioMarin Pharmaceutical", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 44, "start_date": "2022-02-15", "completion_date": "2028-11", "has_results": false, "last_update_posted_date": "2024-05-16", "last_synced_at": "2026-06-10T14:01:15.965Z", "location_count": 13, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • San Diego, California + 10 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05121376" }, { "nct_id": "NCT07298447", "title": "Donidalorsen Treatment in Children With Hereditary Angioedema", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema (HAE)" ], "interventions": [ { "name": "Donidalorsen", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ionis Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "11 Years", "sex": "ALL", "summary": "2 Years to 11 Years" }, "enrollment_count": 20, "start_date": "2026-04-21", "completion_date": "2029-06", "has_results": false, "last_update_posted_date": "2026-05-28", "last_synced_at": "2026-06-10T14:01:15.965Z", "location_count": 5, "location_summary": "Santa Monica, California • Miami, Florida • St Louis, Missouri + 2 more", "locations": [ { "city": "Santa Monica", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Hershey", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT07298447" }, { "nct_id": "NCT04208412", "title": "A Phase II, Cross-over Clinical Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) in the On-demand Treatment of Angioedema Attacks in Adult Subjects With Hereditary Angioedema Type I or II", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "KVD900", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "KalVista Pharmaceuticals, Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 84, "start_date": "2019-07-02", "completion_date": "2020-12-08", "has_results": true, "last_update_posted_date": "2025-05-02", "last_synced_at": "2026-06-10T14:01:15.965Z", "location_count": 6, "location_summary": "Scottsdale, Arizona • Centennial, Colorado • Chevy Chase, Maryland + 3 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Centennial", "state": "Colorado" }, { "city": "Chevy Chase", "state": "Maryland" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Dallas", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04208412" }, { "nct_id": "NCT06361537", "title": "Study of IV Human Plasma-derived C1 Esterase Inhibitor Concentrate in Patients With Congenital C1-INH Deficiency for Treatment and Pre-procedure Preventing of Acute Hereditary Angioedema Attacks", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Acute Hereditary Angio Edema" ], "interventions": [ { "name": "OCTA-C1-INH", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Octapharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": null, "sex": "ALL", "summary": "2 Years and older" }, "enrollment_count": 124, "start_date": "2024-04-30", "completion_date": "2027-06", "has_results": false, "last_update_posted_date": "2026-06-09", "last_synced_at": "2026-06-10T14:01:15.965Z", "location_count": 3, "location_summary": "Centennial, Colorado • Farmington Hills, Michigan • Toledo, Ohio", "locations": [ { "city": "Centennial", "state": "Colorado" }, { "city": "Farmington Hills", "state": "Michigan" }, { "city": "Toledo", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT06361537" }, { "nct_id": "NCT04307381", "title": "An Extension Study of Donidalorsen (IONIS-PKK-LRx) in Participants With Hereditary Angioedema", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "Donidalorsen", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ionis Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2020-03-31", "completion_date": "2025-01-24", "has_results": true, "last_update_posted_date": "2026-05-08", "last_synced_at": "2026-06-10T14:01:15.965Z", "location_count": 6, "location_summary": "Scottsdale, Arizona • Santa Monica, California • Plymouth, Minnesota + 3 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Santa Monica", "state": "California" }, { "city": "Plymouth", "state": "Minnesota" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Hershey", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT04307381" }, { "nct_id": "NCT01576523", "title": "A Study to Evaluate the Clinical Pharmacology and Safety of C1-esterase Inhibitor Administered by the Subcutaneous Route", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Hereditary Angioedema Types I and II" ], "interventions": [ { "name": "C1-esterase inhibitor - single intravenous dose", "type": "BIOLOGICAL" }, { "name": "C1-esterase inhibitor - subcutaneous low dose", "type": "BIOLOGICAL" }, { "name": "C1-esterase inhibitor - subcutaneous medium dose", "type": "BIOLOGICAL" }, { "name": "C1-esterase inhibitor - subcutaneous high dose", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "CSL Behring", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 18, "start_date": "2012-04", "completion_date": "2012-12", "has_results": true, "last_update_posted_date": "2021-02-01", "last_synced_at": "2026-06-10T14:01:15.965Z", "location_count": 5, "location_summary": "Atlanta, Georgia • Chevy Chase, Maryland • Cincinnati, Ohio + 2 more", "locations": [ { "city": "Atlanta", "state": "Georgia" }, { "city": "Chevy Chase", "state": "Maryland" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Toledo", "state": "Ohio" }, { "city": "Hershey", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01576523" }, { "nct_id": "NCT05511922", "title": "PK Subtrial in Adolescent Patients With HAE Type I or II Participating in the KVD900-302 Trial", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "KVD900 600 mg", "type": "DRUG" }, { "name": "Drug: KVD900 300 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "KalVista Pharmaceuticals, Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "12 Years to 17 Years" }, "enrollment_count": 11, "start_date": "2022-10-24", "completion_date": "2026-05-27", "has_results": false, "last_update_posted_date": "2026-06-08", "last_synced_at": "2026-06-10T14:01:15.965Z", "location_count": 20, "location_summary": "Scottsdale, Arizona • Little Rock, Arkansas • San Diego, California + 16 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05511922" } ] }