{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hereditary+Angioedema+Type+II", "query": { "condition": "Hereditary Angioedema Type II" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 24, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hereditary+Angioedema+Type+II&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-05-22T04:51:04.484Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07428499", "title": "Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema (HAE)", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2", "HAE" ], "interventions": [ { "name": "ADX-324 Dose Level 1", "type": "DRUG" }, { "name": "ADX-324 Dose Level 2", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "ADARx Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 90, "start_date": "2026-04-02", "completion_date": "2030-06-30", "has_results": false, "last_update_posted_date": "2026-04-30", "last_synced_at": "2026-05-22T04:51:04.484Z", "location_count": 15, "location_summary": "Litchfield Park, Arizona • Little Rock, Arkansas • San Diego, California + 12 more", "locations": [ { "city": "Litchfield Park", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Orlando", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07428499" }, { "nct_id": "NCT06634420", "title": "HAELO: A Phase 3 Study to Evaluate NTLA-2002 in Participants With Hereditary Angioedema (HAE)", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "NTLA-2002", "type": "BIOLOGICAL" }, { "name": "Normal Saline IV Administration", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Intellia Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": null, "sex": "ALL", "summary": "16 Years and older" }, "enrollment_count": 80, "start_date": "2025-01-15", "completion_date": "2027-09", "has_results": false, "last_update_posted_date": "2026-05-15", "last_synced_at": "2026-05-22T04:51:04.484Z", "location_count": 14, "location_summary": "Scottsdale, Arizona • San Diego, California • Santa Monica, California + 11 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Centennial", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT06634420" }, { "nct_id": "NCT03845400", "title": "A Study of Lanadelumab in Persons With Hereditary Angioedema (HAE) Type I or II in North America", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hereditary Angioedema (HAE)" ], "interventions": [], "intervention_types": [], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 168, "start_date": "2019-03-30", "completion_date": "2022-10-22", "has_results": false, "last_update_posted_date": "2023-03-30", "last_synced_at": "2026-05-22T04:51:04.484Z", "location_count": 23, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • San Diego, California + 20 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT03845400" }, { "nct_id": "NCT05047185", "title": "Dose-ranging Study of Oral PHA-022121 for Prophylaxis Against Angioedema Attacks in Patients With Hereditary Angioedema Type I or Type II", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hereditary Angioedema", "Hereditary Angioedema Type I", "Hereditary Angioedema Type II", "Hereditary Angioedema Types I and II", "Hereditary Angioedema Attack", "Hereditary Angioedema With C1 Esterase Inhibitor Deficiency", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2", "C1 Esterase Inhibitor Deficiency", "C1 Inhibitor Deficiency" ], "interventions": [ { "name": "Deucrictibant low dose", "type": "DRUG" }, { "name": "Deucrictibant high dose", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pharvaris Netherlands B.V.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 34, "start_date": "2022-04-19", "completion_date": "2025-06-30", "has_results": false, "last_update_posted_date": "2025-07-30", "last_synced_at": "2026-05-22T04:51:04.484Z", "location_count": 3, "location_summary": "Birmingham, Alabama • Paradise Valley, Arizona • St Louis, Missouri", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Paradise Valley", "state": "Arizona" }, { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT05047185" }, { "nct_id": "NCT05259917", "title": "A Phase III, Crossover Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "KVD900 600 mg", "type": "DRUG" }, { "name": "KVD900 300 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "KalVista Pharmaceuticals, Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 136, "start_date": "2022-02-22", "completion_date": "2023-12-31", "has_results": true, "last_update_posted_date": "2025-05-02", "last_synced_at": "2026-05-22T04:51:04.484Z", "location_count": 22, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 18 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05259917" }, { "nct_id": "NCT05396105", "title": "Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Hereditary Angioedema", "Hereditary Angioedema Type I", "Hereditary Angioedema Type II", "Hereditary Angioedema Types I and II", "Hereditary Angioedema Attack", "Hereditary Angioedema With C1 Esterase Inhibitor Deficiency", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2", "Hereditary Angioedema - Type 3", "C1 Esterase Inhibitor [C1-INH] Deficiency", "C1 Esterase Inhibitor Deficiency", "C1 Esterase Inhibitor, Deficiency of", "C1 Inhibitor Deficiency", "Hereditary Angioedema Type III", "Hereditary Angioedema (HAE)", "Hereditary Angioedema Type I and II" ], "interventions": [ { "name": "deucrictibant", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pharvaris Netherlands B.V.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 150, "start_date": "2022-12-28", "completion_date": "2027-06", "has_results": false, "last_update_posted_date": "2026-03-16", "last_synced_at": "2026-05-22T04:51:04.484Z", "location_count": 13, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 10 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05396105" }, { "nct_id": "NCT07009262", "title": "A Study Observing US Patients With HAE Type I or II Who Take Icatibant to Treat HAE Attacks", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "Inapplicable", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "KalVista Pharmaceuticals, Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 88, "start_date": "2025-04-21", "completion_date": "2025-11-25", "has_results": false, "last_update_posted_date": "2026-01-13", "last_synced_at": "2026-05-22T04:51:04.484Z", "location_count": 1, "location_summary": "Fairfax, Virginia", "locations": [ { "city": "Fairfax", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT07009262" }, { "nct_id": "NCT06343779", "title": "Study of Oral Deucrictibant Soft Capsule for On-Demand Treatment of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema", "Hereditary Angioedema Type I", "Hereditary Angioedema Type II", "Hereditary Angioedema Types I and II", "Hereditary Angioedema Attack", "Hereditary Angioedema With C1 Esterase Inhibitor Deficiency", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2", "C1 Esterase Inhibitor [C1-INH] Deficiency", "C1 Esterase Inhibitor Deficiency", "C1 Esterase Inhibitor, Deficiency of", "C1 Inhibitor Deficiency", "Hereditary Angioedema - Type 3", "Hereditary Angioedema Type III" ], "interventions": [ { "name": "Deucrictibant, Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pharvaris Netherlands B.V.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "12 Years to 75 Years" }, "enrollment_count": 134, "start_date": "2024-02-26", "completion_date": "2025-10-17", "has_results": false, "last_update_posted_date": "2025-11-21", "last_synced_at": "2026-05-22T04:51:04.484Z", "location_count": 13, "location_summary": "Birmingham, Alabama • Paradise Valley, Arizona • Little Rock, Arkansas + 10 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Paradise Valley", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06343779" }, { "nct_id": "NCT05505916", "title": "An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "KVD900 600 mg", "type": "DRUG" }, { "name": "KVD900 300 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "KalVista Pharmaceuticals, Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 145, "start_date": "2022-10-24", "completion_date": "2026-06-30", "has_results": false, "last_update_posted_date": "2026-02-18", "last_synced_at": "2026-05-22T04:51:04.484Z", "location_count": 20, "location_summary": "Scottsdale, Arizona • Little Rock, Arkansas • San Diego, California + 16 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05505916" }, { "nct_id": "NCT06628713", "title": "Treatment of Angioedema Attacks in Adolescent and Adult Patients 12 Years and Older With HAE Type I or II With Sebetralstat", "overall_status": "APPROVED_FOR_MARKETING", "study_type": "EXPANDED_ACCESS", "phases": [], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "Sebetralstat", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "KalVista Pharmaceuticals, Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": null, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": null, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2025-08-06", "last_synced_at": "2026-05-22T04:51:04.484Z", "location_count": 1, "location_summary": "Scottsdale, Arizona", "locations": [ { "city": "Scottsdale", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT06628713" } ] }