{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hereditary+Central+Nervous+System+Demyelinating+Diseases&page=5", "query": { "condition": "Hereditary Central Nervous System Demyelinating Diseases", "page": 5 }, "page_size": 10 }, "pagination": { "page": 5, "page_size": 10, "total_count": 106, "total_pages": 11, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hereditary+Central+Nervous+System+Demyelinating+Diseases&page=6&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hereditary+Central+Nervous+System+Demyelinating+Diseases&page=4&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-11T18:37:59.214Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01881334", "title": "Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants", "overall_status": "AVAILABLE", "study_type": "EXPANDED_ACCESS", "phases": [], "conditions": [ "Hematologic Malignancies", "Inborn Errors of Metabolism Disorders", "Immune Deficiencies" ], "interventions": [ { "name": "CliniMACS CD34 Reagent System", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Joanne Kurtzberg, MD", "sponsor_class": "OTHER", "healthy_volunteers": null, "eligibility": { "minimum_age": null, "maximum_age": "65 Years", "sex": "ALL", "summary": "Up to 65 Years" }, "enrollment_count": null, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2025-11-20", "last_synced_at": "2026-10-11T18:37:59.214Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01881334" }, { "nct_id": "NCT03886753", "title": "Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products", "overall_status": "TERMINATED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "ALS", "Autism Spectrum Disorder", "Cancer", "Spasticity, Muscle", "Dyskinetic Syndrome", "Epilepsy", "Glaucoma", "Huntington Disease", "Inflammatory Bowel Disease (IBD)", "Multiple Sclerosis", "Neuropathy", "Opioid Use", "Parkinson Disease", "HIV/AIDS", "Ptsd", "Intractable Pain", "Sickle Cell Disease", "Terminal Illness" ], "interventions": [ { "name": "Registry", "type": "OTHER" }, { "name": "PK microsampling of blood", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Children's Hospital of Philadelphia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": null, "sex": "ALL", "summary": "2 Years and older" }, "enrollment_count": 10, "start_date": "2019-05-15", "completion_date": "2020-06-30", "has_results": false, "last_update_posted_date": "2020-07-30", "last_synced_at": "2026-10-11T18:37:59.214Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT03886753" }, { "nct_id": "NCT00983879", "title": "The Natural History of Infantile Globoid Cell Leukodystrophy", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Infantile Globoid Cell Leukodystrophy" ], "interventions": [], "intervention_types": [], "sponsor": "Zymenex A/S", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "2 Years", "sex": "ALL", "summary": "Up to 2 Years" }, "enrollment_count": 6, "start_date": "2009-09", "completion_date": "2014-07", "has_results": false, "last_update_posted_date": "2018-03-08", "last_synced_at": "2026-10-11T18:37:59.214Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00983879" }, { "nct_id": "NCT02699190", "title": "LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Leukodystrophy", "White Matter Disease", "4H Syndrome", "Adrenoleukodystrophy", "AMN", "ALD", "ALD (Adrenoleukodystrophy)", "X-linked Adrenoleukodystrophy", "X-ALD", "Adrenomyeloneuropathy", "Aicardi Goutieres Syndrome", "AGS", "Alexander Disease", "Alexanders Leukodystrophy", "AxD", "ADLD", "Canavan Disease", "CTX", "Cerebrotendinous Xanthomatoses", "Krabbe Disease", "GALC Deficiency", "Globoid Leukodystrophy", "TUBB4A-Related Leukodystrophy", "H-ABC - Hypomyelination, Atrophy of Basal Ganglia and Cerebellum", "HBSL", "HBSL - Hypomyelination, Brain Stem, Spinal Cord, Leg Spasticity", "LBSL", "Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)", "Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation", "ALSP", "CSF1R Gene Mutation", "HCC - Hypomyelination and Congenital Cataract", "MLC1", "Megalencephalic Leukoencephalopathy With Subcortical Cysts 1", "MLD", "Metachromatic Leukodystrophy", "PMD", "Pelizaeus-Merzbacher Disease", "PLP1 Null Syndrome", "PLP1 Gene Duplication | Blood or Tissue | Mutations", "Pelizaeus-Merzbacher-Like Disease, 1", "Peroxisomal Biogenesis Disorder", "Zellweger Syndrome", "Refsum Disease", "Salla Disease", "Sialic Storage Disease", "Sjögren", "Sjogren-Larsson Syndrome", "Van Der Knapp Disease", "Vanishing White Matter Disease", "Charcot-Marie-Tooth", "CMT", "Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency", "Allan-Herndon-Dudley Syndrome", "Cadasil", "Cockayne Syndrome", "Multiple Sulfatase Deficiency", "Gangliosidoses", "GM2 Gangliosidosis", "BPAN", "Labrune Syndrome", "LCC", "Mucopolysaccharidoses", "TBCK-Related Intellectual Disability Syndrome" ], "interventions": [], "intervention_types": [], "sponsor": "Children's Hospital of Philadelphia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "18 Years", "sex": "ALL", "summary": "Up to 18 Years" }, "enrollment_count": 236, "start_date": "2017-01-06", "completion_date": "2024-10-31", "has_results": true, "last_update_posted_date": "2025-11-10", "last_synced_at": "2026-10-11T18:37:59.214Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT02699190" }, { "nct_id": "NCT04141891", "title": "Advancing Understanding of Transportation Options", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Diabetic Retinopathy", "Macular Degeneration", "Glaucoma", "Retinitis Pigmentosa", "Vision Disorders", "Acute Coronary Syndrome", "Implantable Defibrillator User", "Congestive Heart Failure", "Hypertrophic Obstructive Cardiomyopathy", "Orthostatic Hypotension", "Syncope", "Presyncope", "Narcolepsy", "Dementia", "Multiple Sclerosis", "Parkinson Disease", "Brain Injuries", "Spinal Cord Injuries", "Stroke", "Vertigo", "Dizziness", "Seizures", "Substance Use", "Insulin Dependent Diabetes Mellitus", "Arthritis", "Foot--Abnormalities", "Chronic Obstructive Pulmonary Disease", "Obstructive Sleep Apnea", "End Stage Renal Disease", "Sleep Apnea", "Insomnia", "Restless Legs Syndrome" ], "interventions": [ { "name": "Driving Decision Aid", "type": "BEHAVIORAL" }, { "name": "Older Drivers Website", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "University of Colorado, Denver", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 529, "start_date": "2019-12-12", "completion_date": "2023-12-21", "has_results": true, "last_update_posted_date": "2025-02-21", "last_synced_at": "2026-10-11T18:37:59.214Z", "location_count": 3, "location_summary": "La Jolla, California • Aurora, Colorado • Indianapolis, Indiana", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT04141891" }, { "nct_id": "NCT06308718", "title": "Long-term Follow-up Study to Evaluate Safety and Efficacy of FBX-101 in Krabbe Patients", "overall_status": "TERMINATED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Krabbe Disease" ], "interventions": [ { "name": "FBX-101", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Forge Biologics, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 2, "start_date": "2024-08-06", "completion_date": "2025-04-11", "has_results": false, "last_update_posted_date": "2025-09-05", "last_synced_at": "2026-10-11T18:37:59.214Z", "location_count": 1, "location_summary": "Ann Arbor, Michigan", "locations": [ { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT06308718" }, { "nct_id": "NCT02993796", "title": "Krabbe Disease Global Patient Registry", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Krabbe Disease" ], "interventions": [], "intervention_types": [], "sponsor": "State University of New York at Buffalo", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 60, "start_date": "2014-09", "completion_date": "2026-09", "has_results": false, "last_update_posted_date": "2026-07-17", "last_synced_at": "2026-10-11T18:37:59.214Z", "location_count": 1, "location_summary": "Buffalo, New York", "locations": [ { "city": "Buffalo", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02993796" }, { "nct_id": "NCT02815878", "title": "Enhance Wellness for Individuals With Long-Term Physical Disabilities", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Multiple Sclerosis", "Muscular Dystrophy", "Post-polio Syndrome", "Spinal Cord Injury" ], "interventions": [ { "name": "Enhance Wellness", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "University of Washington", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "45 Years", "maximum_age": null, "sex": "ALL", "summary": "45 Years and older" }, "enrollment_count": 240, "start_date": "2014-05-12", "completion_date": "2017-11", "has_results": false, "last_update_posted_date": "2018-04-03", "last_synced_at": "2026-10-11T18:37:59.214Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT02815878" }, { "nct_id": "NCT03233646", "title": "Retinal Imaging in Neurodegenerative Disease", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Alzheimer's Disease", "Mild Cognitive Impairment", "Parkinson's Disease", "Multiple Sclerosis", "Huntington Disease", "Lewy Body Dementia", "Frontotemporal Dementia", "Amyotrophic Lateral Sclerosis (ALS)", "APOE-4 Positive", "Traumatic Brain Injury", "Concussion", "Post-Traumatic Stress Disorder", "Down Syndrome", "Neuro-Degenerative Disease", "Normal Cognition" ], "interventions": [ { "name": "Retinal and Choroidal Imaging", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2000, "start_date": "2017-07-20", "completion_date": "2026-12-31", "has_results": false, "last_update_posted_date": "2026-02-04", "last_synced_at": "2026-10-11T18:37:59.214Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT03233646" }, { "nct_id": "NCT00787865", "title": "Diffusion Tensor Imaging (DTI) in Infants With Krabbe Disease", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Krabbe Disease" ], "interventions": [], "intervention_types": [], "sponsor": "University of Pittsburgh", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": null, "maximum_age": "17 Years", "sex": "ALL", "summary": "Up to 17 Years" }, "enrollment_count": 100, "start_date": "2008-04", "completion_date": "2027-04", "has_results": false, "last_update_posted_date": "2026-03-06", "last_synced_at": "2026-10-11T18:37:59.214Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00787865" } ] }