{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=High+Astigmatism",
    "query": {
      "condition": "High Astigmatism"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 8,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-02T14:08:38.677Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01789333",
      "title": "Higher Irradiance in Keratoconus Ectasia",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Keratoconus",
        "Ectasia"
      ],
      "interventions": [
        {
          "name": "UVA Light with irradiance exposure of 9 mW/cm2",
          "type": "DEVICE"
        },
        {
          "name": "Riboflavin 0.1% ophthalmic solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Stephen Trokel",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2010-09-01",
      "completion_date": "2022-12-30",
      "has_results": false,
      "last_update_posted_date": "2023-02-09",
      "last_synced_at": "2026-09-02T14:08:38.677Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01789333"
    },
    {
      "nct_id": "NCT04698590",
      "title": "Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Keratoconus",
        "Irregular Astigmatism",
        "Corneal Ectasia",
        "Aberration, Corneal Wavefront",
        "Wavefront Aberration, Corneal",
        "Pellucid Marginal Corneal Degeneration",
        "Keratoglobus"
      ],
      "interventions": [
        {
          "name": "Wavefront Guided Scleral Lenses",
          "type": "DEVICE"
        },
        {
          "name": "Traditional Scleral Lenses",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cornea and Laser Eye Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2021-01-15",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-05-03",
      "last_synced_at": "2026-09-02T14:08:38.677Z",
      "location_count": 1,
      "location_summary": "Teaneck, New Jersey",
      "locations": [
        {
          "city": "Teaneck",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04698590"
    },
    {
      "nct_id": "NCT03610997",
      "title": "Photorefractive Keratectomy for Severe Anisometropia and Isoametropia Associated With Amblyopia",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anisometropia",
        "Hyperopia",
        "High Myopia",
        "Amblyopia Isometropic",
        "Amblyopia Bilateral",
        "High Astigmatism"
      ],
      "interventions": [
        {
          "name": "Photorefractive keratectomy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Baylor College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "2 Years to 17 Years"
      },
      "enrollment_count": 200,
      "start_date": "2001-01-01",
      "completion_date": "2024-09-01",
      "has_results": false,
      "last_update_posted_date": "2025-12-08",
      "last_synced_at": "2026-09-02T14:08:38.677Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03610997"
    },
    {
      "nct_id": "NCT00766168",
      "title": "High Refractive Index Material 510(k)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Myopia",
        "Hyperopia"
      ],
      "interventions": [
        {
          "name": "HDS HI 1.54; pahrifocon A",
          "type": "OTHER"
        },
        {
          "name": "FluoroPerm 30 RGP; paflufocon C",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "CooperVision International Limited (CVIL)",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 76,
      "start_date": "2008-01",
      "completion_date": "2008-08",
      "has_results": false,
      "last_update_posted_date": "2012-06-14",
      "last_synced_at": "2026-09-02T14:08:38.677Z",
      "location_count": 8,
      "location_summary": "Lake Elsinore, California • Englewood, Colorado • East Lansing, Michigan + 5 more",
      "locations": [
        {
          "city": "Lake Elsinore",
          "state": "California"
        },
        {
          "city": "Englewood",
          "state": "Colorado"
        },
        {
          "city": "East Lansing",
          "state": "Michigan"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00766168"
    },
    {
      "nct_id": "NCT01601665",
      "title": "Post Approval Study of the AcrySof® IQ Toric Intraocular Lens (IOL) Models SN6AT6-SN6AT9",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cataracts",
        "Astigmatism"
      ],
      "interventions": [
        {
          "name": "SN6AT6 Intraocular Lens",
          "type": "DEVICE"
        },
        {
          "name": "SN6AT7 Intraocular Lens",
          "type": "DEVICE"
        },
        {
          "name": "SN6AT8 Intraocular Lens",
          "type": "DEVICE"
        },
        {
          "name": "SN6AT9 Intraocular Lens",
          "type": "DEVICE"
        },
        {
          "name": "SN60WF Intraocular Lens",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Alcon Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 477,
      "start_date": "2012-02",
      "completion_date": "2015-07",
      "has_results": false,
      "last_update_posted_date": "2015-08-04",
      "last_synced_at": "2026-09-02T14:08:38.677Z",
      "location_count": 1,
      "location_summary": "Fort Worth, Texas",
      "locations": [
        {
          "city": "Fort Worth",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01601665"
    },
    {
      "nct_id": "NCT02565537",
      "title": "High Resolution Wavefront-guided vs. Wavefront Optimized LASIK",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nearsightedness",
        "Astigmatism"
      ],
      "interventions": [
        {
          "name": "LASIK",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "21 Years to 60 Years"
      },
      "enrollment_count": 100,
      "start_date": "2015-10",
      "completion_date": "2025-04-01",
      "has_results": false,
      "last_update_posted_date": "2025-04-24",
      "last_synced_at": "2026-09-02T14:08:38.677Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02565537"
    },
    {
      "nct_id": "NCT00762541",
      "title": "Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Moderate to High Myopia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Myopia"
      ],
      "interventions": [
        {
          "name": "MEL 80 Treatment of High Myopia",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Carl Zeiss Meditec, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 129,
      "start_date": "2006-10",
      "completion_date": "2009-07",
      "has_results": false,
      "last_update_posted_date": "2018-07-19",
      "last_synced_at": "2026-09-02T14:08:38.677Z",
      "location_count": 5,
      "location_summary": "San Diego, California • Greenwood Village, Colorado • Kansas City, Missouri + 2 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Greenwood Village",
          "state": "Colorado"
        },
        {
          "city": "Kansas City",
          "state": "Missouri"
        },
        {
          "city": "Eugene",
          "state": "Oregon"
        },
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00762541"
    },
    {
      "nct_id": "NCT04208750",
      "title": "Clinical Investigation of the Vision-R800 Device.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Myopia",
        "Hyperopia",
        "Astigmatism",
        "Presbyopia"
      ],
      "interventions": [
        {
          "name": "Vision R-800 Phoropter",
          "type": "DEVICE"
        },
        {
          "name": "Standard Phoropter",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Pete Kollbaum, OD, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 119,
      "start_date": "2019-11-18",
      "completion_date": "2021-02-01",
      "has_results": true,
      "last_update_posted_date": "2022-03-14",
      "last_synced_at": "2026-09-02T14:08:38.677Z",
      "location_count": 1,
      "location_summary": "Bloomington, Indiana",
      "locations": [
        {
          "city": "Bloomington",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04208750"
    }
  ]
}