{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=High+Grade+Intraepithelial+Neoplasia",
    "query": {
      "condition": "High Grade Intraepithelial Neoplasia"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 72,
    "total_pages": 8,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=High+Grade+Intraepithelial+Neoplasia&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-21T23:47:07.623Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00501306",
      "title": "Assessing Drivers and Barriers to Follow-Up Screening for Anal Cancer in Men Who Have Sex With Men",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Anal Cancer"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Laser Surgery Care",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "MALE",
        "summary": "18 Years to 85 Years · Male only"
      },
      "enrollment_count": 195,
      "start_date": "2007-06",
      "completion_date": "2008-05",
      "has_results": false,
      "last_update_posted_date": "2011-06-23",
      "last_synced_at": "2026-07-21T23:47:07.623Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00501306"
    },
    {
      "nct_id": "NCT00052897",
      "title": "SGN-00101 in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Anal Cancer"
      ],
      "interventions": [
        {
          "name": "HspE7",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "National Cancer Institute (NCI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2002-12",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2013-02-11",
      "last_synced_at": "2026-07-21T23:47:07.623Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00052897"
    },
    {
      "nct_id": "NCT03239223",
      "title": "Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "HSIL",
        "HSIL of Cervix",
        "High-Grade Squamous Intraepithelial Lesions",
        "High-grade Cervical Intraepithelial Neoplasia",
        "Human Papilloma Virus",
        "Cervical Cancer",
        "Cervical Intraepithelial Neoplasia",
        "Cervical Neoplasm",
        "Cervical Dysplasia",
        "CIN"
      ],
      "interventions": [
        {
          "name": "ABI-1968",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Antiva Biosciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "25 Years to 50 Years · Female only"
      },
      "enrollment_count": 16,
      "start_date": "2018-01-01",
      "completion_date": "2018-10-30",
      "has_results": false,
      "last_update_posted_date": "2019-07-10",
      "last_synced_at": "2026-07-21T23:47:07.623Z",
      "location_count": 6,
      "location_summary": "Los Angeles, California • Lake Worth, Florida • Idaho Falls, Idaho + 3 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Lake Worth",
          "state": "Florida"
        },
        {
          "city": "Idaho Falls",
          "state": "Idaho"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03239223"
    },
    {
      "nct_id": "NCT06233331",
      "title": "Use of ACU-D1 in HPV Associated Vulvar and Perianal Lesions in People With HIV",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Human Papilloma Virus",
        "Human Immunodeficiency Virus",
        "Anal Intraepithelial Neoplasia",
        "High-Grade Squamous Intraepithelial Lesions"
      ],
      "interventions": [
        {
          "name": "Dose Level 1 ACU-D1 ointment",
          "type": "DRUG"
        },
        {
          "name": "Dose Level 2 ACU-D1 ointment",
          "type": "DRUG"
        },
        {
          "name": "Dose Level 3 ACU-D1 ointment",
          "type": "DRUG"
        },
        {
          "name": "Vulvar/ Perianal Biopsy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 9,
      "start_date": "2026-06",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2026-05-08",
      "last_synced_at": "2026-07-21T23:47:07.623Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06233331"
    },
    {
      "nct_id": "NCT06075264",
      "title": "Phase II Study of Artesunate Ointment for the Treatment of Vulvar High Grade Squamous Intraepithelial Lesions (Vulvar HSIL, VIN2/3)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Vulvar Diseases",
        "HPV Infection",
        "Vulvar HSIL",
        "Pre-Cancerous Dysplasia",
        "HPV Disease",
        "VIN, Usual Type",
        "VIN 2 of Usual Type",
        "VIN 3 of Usual Type",
        "Vin II",
        "Vin III",
        "VIN Grade 2",
        "VIN Grade 3",
        "High Grade Intraepithelial Neoplasia"
      ],
      "interventions": [
        {
          "name": "Artesunate ointment",
          "type": "DRUG"
        },
        {
          "name": "Placebo ointment",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Frantz Viral Therapeutics, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 27,
      "start_date": "2023-12-06",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2025-08-14",
      "last_synced_at": "2026-07-21T23:47:07.623Z",
      "location_count": 5,
      "location_summary": "Fort Myers, Florida • Indianapolis, Indiana • Cleveland, Ohio + 1 more",
      "locations": [
        {
          "city": "Fort Myers",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "Mayfield Heights",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06075264"
    },
    {
      "nct_id": "NCT02354534",
      "title": "Intravaginal Artesunate for the Treatment of HPV+ High Grade Cervical Intraepithelial Neoplasia (CIN2/3)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cervical Intraepithelial Neoplasia Grade 2/3",
        "High-risk HPV (Any Strain)"
      ],
      "interventions": [
        {
          "name": "Artesunate Suppositories",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 30,
      "start_date": "2015-02",
      "completion_date": "2018-11-06",
      "has_results": true,
      "last_update_posted_date": "2021-04-28",
      "last_synced_at": "2026-07-21T23:47:07.623Z",
      "location_count": 3,
      "location_summary": "Baltimore, Maryland • Towson, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Towson",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02354534"
    },
    {
      "nct_id": "NCT04131413",
      "title": "HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Human Papillomavirus Type 16",
        "Cervical Intraepithelial Neoplasia Grade II",
        "Cervical Intraepithelial Neoplasia, Grade III"
      ],
      "interventions": [
        {
          "name": "pNGVL4aCRTE6E7L2",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "19 Years and older · Female only"
      },
      "enrollment_count": 48,
      "start_date": "2020-09-14",
      "completion_date": "2029-06",
      "has_results": false,
      "last_update_posted_date": "2026-07-02",
      "last_synced_at": "2026-07-21T23:47:07.623Z",
      "location_count": 2,
      "location_summary": "Birmingham, Alabama • Baltimore, Maryland",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04131413"
    },
    {
      "nct_id": "NCT00695422",
      "title": "Detecting Anal and Genital Human Papillomavirus Infection and Squamous Intraepithelial Lesions in HIV-Positive Patients Enrolled in AIDS Cancer Clinical Trials",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Aids-related Malignancies",
        "Lymphoma",
        "Precancerous Condition",
        "Sarcoma"
      ],
      "interventions": [
        {
          "name": "polymerase chain reaction",
          "type": "GENETIC"
        },
        {
          "name": "cytology specimen collection procedure",
          "type": "OTHER"
        },
        {
          "name": "histological technique",
          "type": "OTHER"
        },
        {
          "name": "colposcopic biopsy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "GENETIC",
        "OTHER",
        "PROCEDURE"
      ],
      "sponsor": "AIDS Malignancy Consortium",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 47,
      "start_date": "2008-05-14",
      "completion_date": "2017-04-19",
      "has_results": false,
      "last_update_posted_date": "2020-08-10",
      "last_synced_at": "2026-07-21T23:47:07.623Z",
      "location_count": 10,
      "location_summary": "La Jolla, California • Los Angeles, California • San Francisco, California + 5 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Honolulu",
          "state": "Hawaii"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00695422"
    },
    {
      "nct_id": "NCT03721978",
      "title": "REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Cervical Dysplasia",
        "Cervical High Grade Squamous Intraepithelial Lesion",
        "HSIL"
      ],
      "interventions": [
        {
          "name": "VGX-3100",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Matched Placebo",
          "type": "BIOLOGICAL"
        },
        {
          "name": "CELLECTRA™-5PSP",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DEVICE"
      ],
      "sponsor": "Inovio Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 203,
      "start_date": "2019-02-28",
      "completion_date": "2022-09-15",
      "has_results": true,
      "last_update_posted_date": "2024-10-17",
      "last_synced_at": "2026-07-21T23:47:07.623Z",
      "location_count": 27,
      "location_summary": "Tucson, Arizona • Danbury, Connecticut • Newark, Delaware + 24 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Danbury",
          "state": "Connecticut"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Lake Worth",
          "state": "Florida"
        },
        {
          "city": "Miramar",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03721978"
    },
    {
      "nct_id": "NCT05217940",
      "title": "Screening Women With Prior HPV for Anal Neoplasia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "HPV-related Lower Genital Tract Neoplasias",
        "HPV-related Anal Neoplasias",
        "Early Stage Lower Genital Tract Cancers"
      ],
      "interventions": [
        {
          "name": "Diagnostic tests for anal cancer screening",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "35 Years and older · Female only"
      },
      "enrollment_count": 300,
      "start_date": "2022-03-02",
      "completion_date": "2027-01",
      "has_results": false,
      "last_update_posted_date": "2025-08-22",
      "last_synced_at": "2026-07-21T23:47:07.623Z",
      "location_count": 3,
      "location_summary": "New York, New York • Charleston, South Carolina • Houston, Texas",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Charleston",
          "state": "South Carolina"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05217940"
    }
  ]
}