{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=High+Risk+Prostate+Carcinoma&page=5", "query": { "condition": "High Risk Prostate Carcinoma", "page": 5 }, "page_size": 10 }, "pagination": { "page": 5, "page_size": 10, "total_count": 377, "total_pages": 38, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=High+Risk+Prostate+Carcinoma&page=6&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=High+Risk+Prostate+Carcinoma&page=4&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-07T01:33:11.071Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04452136", "title": "Expanded Access Protocol of 68Ga PSMA 11 PET Imaging of Prostate Cancer", "overall_status": "APPROVED_FOR_MARKETING", "study_type": "EXPANDED_ACCESS", "phases": [], "conditions": [ "Prostatic Neoplasms", "Prostatic Diseases", "Prostate Cancer", "Prostate Cancer Metastatic", "Prostate Cancer Recurrent" ], "interventions": [ { "name": "68GA PSMA-HBED-CC", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Jeanne Link", "sponsor_class": "OTHER", "healthy_volunteers": null, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": null, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2022-03-14", "last_synced_at": "2026-10-07T01:33:11.071Z", "location_count": 1, "location_summary": "Portland, Oregon", "locations": [ { "city": "Portland", "state": "Oregon" } ], "official_url": "https://clinicaltrials.gov/study/NCT04452136" }, { "nct_id": "NCT06929065", "title": "Randomized Trial of HIFU vs. Cryo for Prostate Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Prostate Cancer", "Prostate Cancer Stage I", "Prostate Cancer Stage II", "High Intensity Focused Ultrasound", "HIFU", "Cryoablation" ], "interventions": [ { "name": "HIFU vs Cryoablation", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "Kaiser Permanente", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "40 Years", "maximum_age": "80 Years", "sex": "MALE", "summary": "40 Years to 80 Years · Male only" }, "enrollment_count": 50, "start_date": "2023-04-01", "completion_date": "2025-02-01", "has_results": false, "last_update_posted_date": "2025-04-15", "last_synced_at": "2026-10-07T01:33:11.071Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06929065" }, { "nct_id": "NCT02346253", "title": "High-Dose Brachytherapy in Treating Patients With Prostate Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Prostate Adenocarcinoma", "Stage I Prostate Cancer", "Stage IIA Prostate Cancer", "Stage IIB Prostate Cancer", "Stage III Prostate Cancer" ], "interventions": [ { "name": "Internal Radiation Therapy", "type": "RADIATION" }, { "name": "Bicalutamide", "type": "DRUG" }, { "name": "Leuprolide Acetate", "type": "DRUG" }, { "name": "Goserelin Acetate", "type": "DRUG" }, { "name": "Triptorelin Pamoate", "type": "DRUG" }, { "name": "Degarelix", "type": "DRUG" }, { "name": "Laboratory Biomarker Analysis", "type": "OTHER" }, { "name": "Quality-of-Life Assessment", "type": "OTHER" } ], "intervention_types": [ "RADIATION", "DRUG", "OTHER" ], "sponsor": "Stanford University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "MALE", "summary": "Male only" }, "enrollment_count": 146, "start_date": "2015-01-13", "completion_date": "2026-05-17", "has_results": false, "last_update_posted_date": "2026-07-02", "last_synced_at": "2026-10-07T01:33:11.071Z", "location_count": 1, "location_summary": "Stanford, California", "locations": [ { "city": "Stanford", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02346253" }, { "nct_id": "NCT07746414", "title": "Effects of Exercise Prior to Radical Prostatectomy", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Recovery", "Post Prostatectomy" ], "interventions": [ { "name": "High-intensity interval training (HIIT) exercise", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "35 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "35 Years to 80 Years" }, "enrollment_count": 20, "start_date": "2026-08", "completion_date": "2027-08", "has_results": false, "last_update_posted_date": "2026-08-07", "last_synced_at": "2026-10-07T01:33:11.071Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT07746414" }, { "nct_id": "NCT05794906", "title": "A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Biochemically Recurrent Prostate Cancer" ], "interventions": [ { "name": "Darolutamide (BAY1841788, Nubeqa)", "type": "DRUG" }, { "name": "Placebo matching darolutamide", "type": "OTHER" }, { "name": "ADT", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Bayer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 985, "start_date": "2023-04-03", "completion_date": "2030-03-29", "has_results": false, "last_update_posted_date": "2026-07-07", "last_synced_at": "2026-10-07T01:33:11.071Z", "location_count": 25, "location_summary": "Phoenix, Arizona • Duarte, California • Los Angeles, California + 18 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Duarte", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05794906" }, { "nct_id": "NCT02420977", "title": "Evaluation of PSMA-based PET as an Imaging Biomarker in Prostate Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Advanced Prostate Cancer" ], "interventions": [ { "name": "Pelvic DCFPyL PET-MRI fusion or PET/MRI", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "MALE", "summary": "18 Years to 100 Years · Male only" }, "enrollment_count": 23, "start_date": "2018-12-06", "completion_date": "2025-03-01", "has_results": false, "last_update_posted_date": "2025-03-19", "last_synced_at": "2026-10-07T01:33:11.071Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02420977" }, { "nct_id": "NCT01664130", "title": "High-Dose Stereotactic Radiation for Prostate Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Adenocarcinoma of the Prostate", "Recurrent Prostate Cancer", "Stage I Prostate Cancer", "Stage IIA Prostate Cancer", "Stage IIB Prostate Cancer", "Stage III Prostate Cancer" ], "interventions": [ { "name": "stereotactic body radiation therapy", "type": "RADIATION" }, { "name": "quality-of-life assessment", "type": "PROCEDURE" }, { "name": "laboratory biomarker analysis", "type": "OTHER" } ], "intervention_types": [ "RADIATION", "PROCEDURE", "OTHER" ], "sponsor": "Case Comprehensive Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 35, "start_date": "2012-07", "completion_date": "2017-01-12", "has_results": true, "last_update_posted_date": "2020-05-21", "last_synced_at": "2026-10-07T01:33:11.071Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT01664130" }, { "nct_id": "NCT03296124", "title": "Prognostic Value of Androgen Receptor Expression and Mutations Within Oncogenes and Tumor Suppressor Genes in Patients Treated for High Risk Prostate Cancer With Proton Therapy (PRX32)", "overall_status": "WITHDRAWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Prostate Cancer" ], "interventions": [], "intervention_types": [], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 0, "start_date": "2017-12-07", "completion_date": "2020-09", "has_results": false, "last_update_posted_date": "2018-11-16", "last_synced_at": "2026-10-07T01:33:11.071Z", "location_count": 1, "location_summary": "Jacksonville, Florida", "locations": [ { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03296124" }, { "nct_id": "NCT04030559", "title": "Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "ATM Gene Mutation", "BRCA1 Gene Mutation", "BRCA2 Gene Mutation", "BRIP1 Gene Mutation", "CDK12 Gene Mutation", "CHEK1 Gene Mutation", "CHEK2 Gene Mutation", "DNA Damage Response Gene Mutation", "DNA Repair Gene Mutation", "FANCA Gene Mutation", "FANCD2 Gene Mutation", "FANCL Gene Mutation", "GEN1 Gene Mutation", "NBN Gene Mutation", "Prostate Carcinoma", "RAD51 Gene Mutation", "RAD51C Gene Mutation" ], "interventions": [ { "name": "Niraparib", "type": "DRUG" }, { "name": "Niraparib Tosylate Monohydrate", "type": "DRUG" }, { "name": "Radical Prostatectomy", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "University of California, Davis", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 11, "start_date": "2020-02-25", "completion_date": "2025-11-07", "has_results": true, "last_update_posted_date": "2026-05-14", "last_synced_at": "2026-10-07T01:33:11.071Z", "location_count": 1, "location_summary": "Sacramento, California", "locations": [ { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04030559" }, { "nct_id": "NCT06085664", "title": "A Pilot Presurgical Trial of REGN5678 (Anti-PSMA x CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Prostate Cancer", "Radical Prostatectomy" ], "interventions": [ { "name": "REGN5678", "type": "DRUG" }, { "name": "Piflufolastat F18", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "M.D. Anderson Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 42, "start_date": "2023-12-04", "completion_date": "2028-06-30", "has_results": false, "last_update_posted_date": "2026-08-25", "last_synced_at": "2026-10-07T01:33:11.071Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06085664" } ] }