{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=High-risk+Cardiac+Patients&page=2",
    "query": {
      "condition": "High-risk Cardiac Patients",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=High-risk+Cardiac+Patients&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T05:57:13.106Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04415047",
      "title": "The JenaValve ALIGN-AR Pivotal Trial",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Regurgitation",
        "Aortic Valve Insufficiency",
        "Aortic Insufficiency",
        "Aortic Valve Disease"
      ],
      "interventions": [
        {
          "name": "JenaValve Trilogy Heart Valve System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "JenaValve Technology, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 180,
      "start_date": "2020-05-22",
      "completion_date": "2028-08",
      "has_results": false,
      "last_update_posted_date": "2022-09-13",
      "last_synced_at": "2026-06-26T05:57:13.106Z",
      "location_count": 30,
      "location_summary": "Tucson, Arizona • Los Angeles, California • San Diego, California + 25 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04415047"
    },
    {
      "nct_id": "NCT02732691",
      "title": "JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Valve Stenosis",
        "Heart Valve Diseases",
        "Heart Diseases",
        "Cardiovascular Diseases",
        "Ventricular Outflow Obstruction"
      ],
      "interventions": [
        {
          "name": "JenaValve Pericardial TAVR System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "JenaValve Technology, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 68,
      "start_date": "2016-10-21",
      "completion_date": "2024-04",
      "has_results": true,
      "last_update_posted_date": "2022-11-22",
      "last_synced_at": "2026-06-26T05:57:13.106Z",
      "location_count": 2,
      "location_summary": "Washington D.C., District of Columbia • New York, New York",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02732691"
    },
    {
      "nct_id": "NCT01047735",
      "title": "The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 2 Diabetes Mellitus",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Roux-en-Y Gastric Bypass Surgery",
          "type": "PROCEDURE"
        },
        {
          "name": "Laparoscopic Adjustable Gastric Banding",
          "type": "PROCEDURE"
        },
        {
          "name": "Lifestyle Weight Loss Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "25 Years to 55 Years"
      },
      "enrollment_count": 69,
      "start_date": "2009-09-01",
      "completion_date": "2028-07-01",
      "has_results": false,
      "last_update_posted_date": "2026-06-11",
      "last_synced_at": "2026-06-26T05:57:13.106Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01047735"
    },
    {
      "nct_id": "NCT00627328",
      "title": "The Atrial High Rate Episodes in Pacemaker Patients",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Arrhythmia",
        "Atrial Fibrillation",
        "Atrioventricular Block",
        "Bradycardia",
        "Sick Sinus Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Medtronic Cardiac Rhythm and Heart Failure",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 427,
      "start_date": "2000-07",
      "completion_date": "2004-09",
      "has_results": false,
      "last_update_posted_date": "2008-03-03",
      "last_synced_at": "2026-06-26T05:57:13.106Z",
      "location_count": 37,
      "location_summary": "Hot Springs, Arkansas • Little Rock, Arkansas • Fresno, California + 34 more",
      "locations": [
        {
          "city": "Hot Springs",
          "state": "Arkansas"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Fresno",
          "state": "California"
        },
        {
          "city": "Glendale",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00627328"
    },
    {
      "nct_id": "NCT01900600",
      "title": "Interleukin-1 Blockade With Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated High Sensitivity C-reactive Protein (Hs-CRP)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prior Acute Myocardial Infarction",
        "Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l)",
        "Reduced Left Ventricle Ejection Fraction (<50%)",
        "Symptoms of Heart Failure (NYHA Class II-III)"
      ],
      "interventions": [
        {
          "name": "Cardiopulmonary exercise test",
          "type": "OTHER"
        },
        {
          "name": "Echocardiogram",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "110 Years",
        "sex": "ALL",
        "summary": "18 Years to 110 Years"
      },
      "enrollment_count": 15,
      "start_date": "2013-04",
      "completion_date": "2015-01-08",
      "has_results": false,
      "last_update_posted_date": "2018-10-10",
      "last_synced_at": "2026-06-26T05:57:13.106Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01900600"
    },
    {
      "nct_id": "NCT03872401",
      "title": "Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Coronary Heart Disease (CHD)"
      ],
      "interventions": [
        {
          "name": "Evolocumab",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Amgen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "79 Years",
        "sex": "ALL",
        "summary": "50 Years to 79 Years"
      },
      "enrollment_count": 12301,
      "start_date": "2019-06-11",
      "completion_date": "2025-07-25",
      "has_results": true,
      "last_update_posted_date": "2026-06-25",
      "last_synced_at": "2026-06-26T05:57:13.106Z",
      "location_count": 145,
      "location_summary": "Athens, Alabama • Birmingham, Alabama • Huntsville, Alabama + 127 more",
      "locations": [
        {
          "city": "Athens",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Huntsville",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03872401"
    },
    {
      "nct_id": "NCT01809730",
      "title": "Pilot Study: Cardiovascular Events in High Risk Orthopedic Surgical Patients",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Coronary Artery Disease",
        "Cerebral Vascular Disease",
        "Peripheral Artery Disease",
        "Renal Insufficiency",
        "Diabetes",
        "COPD",
        "Hypertension",
        "Active Smoker",
        "Cancer",
        "CHF",
        "Prior DVT/PE"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "NYU Langone Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2012-05",
      "completion_date": "2020-01",
      "has_results": false,
      "last_update_posted_date": "2015-11-17",
      "last_synced_at": "2026-06-26T05:57:13.106Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01809730"
    },
    {
      "nct_id": "NCT04825067",
      "title": "Remote Monitoring of High-Risk Patients With Chronic Cardiopulmonary Diseases",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Congestive Heart Failure",
        "Asthma",
        "Chronic Obstructive Pulmonary Disease",
        "Cystic Fibrosis"
      ],
      "interventions": [
        {
          "name": "Respiratory Sensor measurements",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Institute of Bioengineering and Bioimaging (IBB)",
      "sponsor_class": "OTHER_GOV",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2022-04-01",
      "completion_date": "2022-12-31",
      "has_results": false,
      "last_update_posted_date": "2022-09-29",
      "last_synced_at": "2026-06-26T05:57:13.106Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04825067"
    },
    {
      "nct_id": "NCT05937685",
      "title": "Reducing Blood Pressure in Patients With High Cardiovascular Risk",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Myocardial Infarction",
        "Hypertension",
        "Stroke"
      ],
      "interventions": [
        {
          "name": "BP REACH Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "35 Years and older"
      },
      "enrollment_count": 546,
      "start_date": "2023-09-01",
      "completion_date": "2026-07",
      "has_results": false,
      "last_update_posted_date": "2025-05-14",
      "last_synced_at": "2026-06-26T05:57:13.106Z",
      "location_count": 4,
      "location_summary": "Downey, California • Los Angeles, California • Sylmar, California + 1 more",
      "locations": [
        {
          "city": "Downey",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Sylmar",
          "state": "California"
        },
        {
          "city": "Torrance",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05937685"
    },
    {
      "nct_id": "NCT05592847",
      "title": "A Study of the Effect of a Nurse Navigator Program on High Risk Patients",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Patient Readmission",
        "Arthroplasty, Replacement, Knee",
        "Arthroplasty, Replacement, Hip",
        "Heart Failure",
        "Pulmonary Disease, Chronic Obstructive",
        "Renal Insufficiency",
        "Body Mass Index",
        "Alcoholism"
      ],
      "interventions": [
        {
          "name": "Nurse Navigator Program",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2027-01",
      "completion_date": "2027-06",
      "has_results": false,
      "last_update_posted_date": "2026-03-19",
      "last_synced_at": "2026-06-26T05:57:13.106Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05592847"
    }
  ]
}