{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hopelessness",
    "query": {
      "condition": "Hopelessness"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 14,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hopelessness&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:44:52.144Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04385693",
      "title": "Intentional Pulpotomy to Preserve Hopeless Molars",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pulpitis",
        "Dental Pulp Diseases",
        "Tooth Diseases"
      ],
      "interventions": [
        {
          "name": "Pulpotomy",
          "type": "PROCEDURE"
        },
        {
          "name": "Extraction and placement of space maintainer",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "10 Years",
        "sex": "ALL",
        "summary": "5 Years to 10 Years"
      },
      "enrollment_count": 17,
      "start_date": "2020-06-12",
      "completion_date": "2023-04-12",
      "has_results": false,
      "last_update_posted_date": "2023-06-06",
      "last_synced_at": "2026-05-22T09:44:52.144Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04385693"
    },
    {
      "nct_id": "NCT00042575",
      "title": "Dose Escalation, Double-Blind Treatment With Duloxetine Hydrochloride Once Daily Dosing for Evaluation of Safety in Major Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Duloxetine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eli Lilly and Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 120,
      "start_date": "2002-06",
      "completion_date": "2002-08",
      "has_results": false,
      "last_update_posted_date": "2006-07-19",
      "last_synced_at": "2026-05-22T09:44:52.144Z",
      "location_count": 9,
      "location_summary": "Trumbull, Connecticut • Lafayette, Indiana • Gaithersburg, Maryland + 6 more",
      "locations": [
        {
          "city": "Trumbull",
          "state": "Connecticut"
        },
        {
          "city": "Lafayette",
          "state": "Indiana"
        },
        {
          "city": "Gaithersburg",
          "state": "Maryland"
        },
        {
          "city": "Belmont",
          "state": "Massachusetts"
        },
        {
          "city": "Omaha",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00042575"
    },
    {
      "nct_id": "NCT05816317",
      "title": "Randomized Controlled Trial of a Single-session Mechanism-focused Intervention for Suicidal Thoughts and Behaviors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Suicidal Ideation",
        "Hopelessness",
        "Wish to Live",
        "Wish to Die"
      ],
      "interventions": [
        {
          "name": "Single-Session Mechanism-Focused Intervention (SSMFI)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Distress Tolerance Skills Review",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Shannon E. Sauer-Zavala",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 38,
      "start_date": "2024-10-16",
      "completion_date": "2025-05-20",
      "has_results": false,
      "last_update_posted_date": "2025-08-01",
      "last_synced_at": "2026-05-22T09:44:52.144Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05816317"
    },
    {
      "nct_id": "NCT00042562",
      "title": "Open-Label Treatment With Duloxetine Hydrochloride Once-Daily Dosing for Evaluation of Stabilization Dose in Patients With Major Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "duloxetine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eli Lilly and Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": null,
      "start_date": "2002-12",
      "completion_date": "2003-12",
      "has_results": false,
      "last_update_posted_date": "2006-07-19",
      "last_synced_at": "2026-05-22T09:44:52.144Z",
      "location_count": 23,
      "location_summary": "Carlsbad, California • Los Angeles, California • Stanford, California + 20 more",
      "locations": [
        {
          "city": "Carlsbad",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Cromwell",
          "state": "Connecticut"
        },
        {
          "city": "Coral Springs",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00042562"
    },
    {
      "nct_id": "NCT04253002",
      "title": "Preventing Suicide in African American Adolescents",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Suicide"
      ],
      "interventions": [
        {
          "name": "Robinson's Culturally Adapted Coping with Stress Course (A-CWS)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Standard Care Control Condition",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "DePaul University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 512,
      "start_date": "2022-02-01",
      "completion_date": "2026-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-06-05",
      "last_synced_at": "2026-05-22T09:44:52.144Z",
      "location_count": 6,
      "location_summary": "Chicago, Illinois • Maywood, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04253002"
    },
    {
      "nct_id": "NCT07568054",
      "title": "Neural Correlates of Suicidal Behavior in Youth",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Suicidal Ideation",
        "Suicide Attempt",
        "Suicidal Behavior",
        "Depression / Major Depressive Disorder",
        "Hopelessness",
        "Neurobiological"
      ],
      "interventions": [
        {
          "name": "CAMS",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "The Cleveland Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "24 Years",
        "sex": "ALL",
        "summary": "14 Years to 24 Years"
      },
      "enrollment_count": 60,
      "start_date": "2026-04-13",
      "completion_date": "2031-10-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-05",
      "last_synced_at": "2026-05-22T09:44:52.144Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07568054"
    },
    {
      "nct_id": "NCT01189812",
      "title": "Safety and Efficacy Study of Citalopram and Lithium for the Treatment of Depressive Mood Disorder Symptoms",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Dysthymia",
        "Depression Not Otherwise Specified",
        "Borderline Personality Disorder"
      ],
      "interventions": [
        {
          "name": "Lithium Carbonate",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "Citalopram",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Columbia Northwest Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 80,
      "start_date": "2010-03",
      "completion_date": "2011-01",
      "has_results": true,
      "last_update_posted_date": "2011-08-24",
      "last_synced_at": "2026-05-22T09:44:52.144Z",
      "location_count": 2,
      "location_summary": "San Diego, California • Bellevue, Washington",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Bellevue",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01189812"
    },
    {
      "nct_id": "NCT03907891",
      "title": "Reducing Hopelessness Through Improved Physical Activity in Adults With Heart Disease: With COVID-19 Considerations",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ischemic Heart Disease",
        "Hopelessness",
        "Physical Activity",
        "Motivation",
        "Social Support",
        "Covid19"
      ],
      "interventions": [
        {
          "name": "Motivational social support from nurse",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Motivational social support from nurse with additional support from significant other",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Attention control",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Illinois at Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 224,
      "start_date": "2019-08-01",
      "completion_date": "2024-09-16",
      "has_results": true,
      "last_update_posted_date": "2026-02-13",
      "last_synced_at": "2026-05-22T09:44:52.144Z",
      "location_count": 1,
      "location_summary": "Grand Rapids, Michigan",
      "locations": [
        {
          "city": "Grand Rapids",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03907891"
    },
    {
      "nct_id": "NCT07191262",
      "title": "To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth"
      ],
      "interventions": [
        {
          "name": "0.12% CHX and Essential Oil mouthrinse",
          "type": "OTHER"
        },
        {
          "name": "2.6% EDTA and 0.2% EDTA mouth rinse",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 40,
      "start_date": "2026-03-02",
      "completion_date": "2028-12",
      "has_results": false,
      "last_update_posted_date": "2026-03-20",
      "last_synced_at": "2026-05-22T09:44:52.144Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07191262"
    },
    {
      "nct_id": "NCT01599247",
      "title": "Natural History of Hopelessness, Suicidality, and Optimism in Psychiatric Inpatients Following Discharge",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Suicide, Attempted",
        "Suicidal Ideation"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 46,
      "start_date": "2011-07",
      "completion_date": "2013-01",
      "has_results": false,
      "last_update_posted_date": "2014-08-08",
      "last_synced_at": "2026-05-22T09:44:52.144Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01599247"
    }
  ]
}