{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypercapnia&page=2",
    "query": {
      "condition": "Hypercapnia",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypercapnia&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T09:17:26.797Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03993002",
      "title": "DAMP-Mediated Innate Immune Failure and Pneumonia After Trauma - the Harvard-Longwood (HALO) Campus Area Consortium",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Normoxia with Normocarbia",
          "type": "OTHER"
        },
        {
          "name": "Normoxia with Hypercarbia",
          "type": "OTHER"
        },
        {
          "name": "Hyperoxia with Normocarbia",
          "type": "OTHER"
        },
        {
          "name": "Hyperoxia with Hypercarbia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1,
      "start_date": "2019-11-15",
      "completion_date": "2021-10-01",
      "has_results": false,
      "last_update_posted_date": "2022-03-18",
      "last_synced_at": "2026-06-10T09:17:26.797Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03993002"
    },
    {
      "nct_id": "NCT01317329",
      "title": "\"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved\"",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Apnea, Obstructive",
        "Hypoxia",
        "Hypercapnia",
        "Sleep Disorders",
        "Obesity",
        "Hypertension",
        "Coronary Artery Vasospasm",
        "Right Ventricular Overload",
        "Left Ventricular Function Systolic Dysfunction",
        "Ventricular Hypertrophy"
      ],
      "interventions": [
        {
          "name": "Clinically prescribed CPAP therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "21 Years to 50 Years"
      },
      "enrollment_count": 90,
      "start_date": "2011-03",
      "completion_date": "2014-12",
      "has_results": false,
      "last_update_posted_date": "2020-03-06",
      "last_synced_at": "2026-06-10T09:17:26.797Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01317329"
    },
    {
      "nct_id": "NCT06047405",
      "title": "NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypercapnic Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Average Volume-Assured Pressure Support (AVAPS)",
          "type": "DEVICE"
        },
        {
          "name": "Bilevel Positive Airway Pressure Spontaneous Timed (BIPAP S/T)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2023-10-07",
      "completion_date": "2026-09-01",
      "has_results": false,
      "last_update_posted_date": "2023-10-31",
      "last_synced_at": "2026-06-10T09:17:26.797Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06047405"
    },
    {
      "nct_id": "NCT06636825",
      "title": "Influence of Caffeine on Psychomotor Vigilance and Carbon Dioxide Tolerance During Graded Hypercapnia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypercapnia"
      ],
      "interventions": [
        {
          "name": "Graded hypercapnia",
          "type": "OTHER"
        },
        {
          "name": "Caffeine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "United States Army Research Institute of Environmental Medicine",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 29,
      "start_date": "2023-11-09",
      "completion_date": "2024-09-17",
      "has_results": false,
      "last_update_posted_date": "2024-10-15",
      "last_synced_at": "2026-06-10T09:17:26.797Z",
      "location_count": 1,
      "location_summary": "Natick, Massachusetts",
      "locations": [
        {
          "city": "Natick",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06636825"
    },
    {
      "nct_id": "NCT05116397",
      "title": "Influence of Graded Hypercapnia on Endurance Exercise Performance",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypercapnia"
      ],
      "interventions": [
        {
          "name": "Inspired gas",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "United States Army Research Institute of Environmental Medicine",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 15,
      "start_date": "2021-09-10",
      "completion_date": "2022-04-14",
      "has_results": false,
      "last_update_posted_date": "2022-05-31",
      "last_synced_at": "2026-06-10T09:17:26.797Z",
      "location_count": 1,
      "location_summary": "Natick, Massachusetts",
      "locations": [
        {
          "city": "Natick",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05116397"
    },
    {
      "nct_id": "NCT01927237",
      "title": "Pulmonary Vascular Effects of Respiratory Rate & Carbon Dioxide",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Low Tidal Volume Ventilation",
        "Acute Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "HLR",
          "type": "OTHER"
        },
        {
          "name": "EHR",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 0,
      "start_date": "2013-09",
      "completion_date": "2014-08",
      "has_results": false,
      "last_update_posted_date": "2017-02-27",
      "last_synced_at": "2026-06-10T09:17:26.797Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01927237"
    },
    {
      "nct_id": "NCT01214200",
      "title": "High Intensity Non-Invasive Positive Pressure Ventilation (HINPPV)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Obstructive Pulmonary Disease (COPD)"
      ],
      "interventions": [
        {
          "name": "Bilevel positive airway pressure (BiPAP)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Philips Respironics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "Up to 80 Years"
      },
      "enrollment_count": 20,
      "start_date": "2010-08",
      "completion_date": "2012-12",
      "has_results": true,
      "last_update_posted_date": "2019-01-02",
      "last_synced_at": "2026-06-10T09:17:26.797Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01214200"
    },
    {
      "nct_id": "NCT00273377",
      "title": "The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Surgical Wound Infection",
        "Surgery, Colon"
      ],
      "interventions": [
        {
          "name": "Mild intraoperative hypercapnia (50 mmHg vs. 30 mmHg)",
          "type": "OTHER"
        },
        {
          "name": "Supplemental oxygen (80% vs. 30%)",
          "type": "OTHER"
        },
        {
          "name": "Dexamethasone",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "The Cleveland Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 2000,
      "start_date": "2002-05",
      "completion_date": "2007-12",
      "has_results": false,
      "last_update_posted_date": "2016-06-29",
      "last_synced_at": "2026-06-10T09:17:26.797Z",
      "location_count": 2,
      "location_summary": "Louisville, Kentucky • Cleveland, Ohio",
      "locations": [
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00273377"
    },
    {
      "nct_id": "NCT03353064",
      "title": "Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypercapnic Respiratory Failure",
        "Chronic Obstructive Pulmonary Disease",
        "Obesity Hypoventilation Syndrome",
        "Sleep Disordered Breathing",
        "Neuromuscular Diseases"
      ],
      "interventions": [
        {
          "name": "Vivify",
          "type": "OTHER"
        },
        {
          "name": "EMS",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Albert Einstein Healthcare Network",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4,
      "start_date": "2017-10-18",
      "completion_date": "2018-10-26",
      "has_results": false,
      "last_update_posted_date": "2018-10-29",
      "last_synced_at": "2026-06-10T09:17:26.797Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03353064"
    },
    {
      "nct_id": "NCT01815034",
      "title": "Trancutaneous Monitoring to Avoid Hypercapnea During Complex Catheter Ablations",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hypercapnia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "The Cleveland Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 50,
      "start_date": "2013-03",
      "completion_date": "2013-07",
      "has_results": false,
      "last_update_posted_date": "2014-08-19",
      "last_synced_at": "2026-06-10T09:17:26.797Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01815034"
    }
  ]
}