{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypercarbia&page=2",
    "query": {
      "condition": "Hypercarbia",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypercarbia&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T21:00:42.485Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03522805",
      "title": "Impact of Non-invasive Ventilation in Hypercapnic COPD",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Copd",
        "Chronic Obstructive Pulmonary Disease",
        "Hypercapnia",
        "Chronic Respiratory Failure",
        "Hypoventilation"
      ],
      "interventions": [
        {
          "name": "High-intensity non-invasive ventilation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "45 Years to 75 Years"
      },
      "enrollment_count": 6,
      "start_date": "2018-04-23",
      "completion_date": "2018-11-21",
      "has_results": false,
      "last_update_posted_date": "2020-08-27",
      "last_synced_at": "2026-07-22T21:00:42.485Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03522805"
    },
    {
      "nct_id": "NCT02840851",
      "title": "Brain Blood Flow: Age and Gender",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Healthy",
        "Aging"
      ],
      "interventions": [
        {
          "name": "MRI",
          "type": "DEVICE"
        },
        {
          "name": "TCD",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "20 Years to 64 Years"
      },
      "enrollment_count": 46,
      "start_date": "2016-11",
      "completion_date": "2018-09",
      "has_results": false,
      "last_update_posted_date": "2019-12-09",
      "last_synced_at": "2026-07-22T21:00:42.485Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02840851"
    },
    {
      "nct_id": "NCT04263532",
      "title": "Vector Efficacy Cross-Over Pilot Study",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [],
      "conditions": [
        "Chronic Obstructive Pulmonary Disease"
      ],
      "interventions": [
        {
          "name": "Modified BiPAP A40 with Vector Algorithm (Vector)",
          "type": "DEVICE"
        },
        {
          "name": "Modified BiPAP A40 with Standard of Care Settings",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Philips Clinical & Medical Affairs Global",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "40 Years to 80 Years"
      },
      "enrollment_count": 21,
      "start_date": "2020-01-21",
      "completion_date": "2023-11-17",
      "has_results": true,
      "last_update_posted_date": "2025-05-09",
      "last_synced_at": "2026-07-22T21:00:42.485Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04263532"
    },
    {
      "nct_id": "NCT07294768",
      "title": "Mechanical Power-Guided Lung Protective Ventilation (VentCoach) in Acute Hypoxemic and/or Hypercapnic Respiratory Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mechanical Ventilation"
      ],
      "interventions": [
        {
          "name": "VentCoach",
          "type": "OTHER"
        },
        {
          "name": "Standard of Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2023-10-11",
      "completion_date": "2024-05-17",
      "has_results": false,
      "last_update_posted_date": "2025-12-19",
      "last_synced_at": "2026-07-22T21:00:42.485Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07294768"
    },
    {
      "nct_id": "NCT02996162",
      "title": "Hypercapnia and Its Association With Long-term Respiratory Morbidities in Premature Infants With Chronic Lung Disease",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Bronchopulmonary Dysplasia"
      ],
      "interventions": [
        {
          "name": "Massimo Root Monitoring System",
          "type": "DEVICE"
        },
        {
          "name": "ISA-Infrared Sidestream Gas Analyzer",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Days",
        "maximum_age": "1 Year",
        "sex": "ALL",
        "summary": "3 Days to 1 Year"
      },
      "enrollment_count": 0,
      "start_date": "2020-12-01",
      "completion_date": "2021-05-06",
      "has_results": false,
      "last_update_posted_date": "2021-08-02",
      "last_synced_at": "2026-07-22T21:00:42.485Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02996162"
    },
    {
      "nct_id": "NCT05761756",
      "title": "Oxygen Toxicity: Mechanisms in Humans",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Oxygen Toxicity",
        "Hypercapnia",
        "Seizures"
      ],
      "interventions": [
        {
          "name": "Sleep Deprivation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Caffeine",
          "type": "DRUG"
        },
        {
          "name": "Methylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Carbon Dioxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 62,
      "start_date": "2023-11-28",
      "completion_date": "2026-08-31",
      "has_results": false,
      "last_update_posted_date": "2025-10-23",
      "last_synced_at": "2026-07-22T21:00:42.485Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05761756"
    },
    {
      "nct_id": "NCT00001845",
      "title": "Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Healthy",
        "Hypercapnia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Institutes of Health Clinical Center (CC)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 30,
      "start_date": "1999-09",
      "completion_date": "2004-08",
      "has_results": false,
      "last_update_posted_date": "2008-03-04",
      "last_synced_at": "2026-07-22T21:00:42.485Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00001845"
    },
    {
      "nct_id": "NCT01557920",
      "title": "The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Airway Complication of Anaesthesia",
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Propofol",
          "type": "DRUG"
        },
        {
          "name": "Sevoflurane",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 18,
      "start_date": "2013-01",
      "completion_date": "2014-03",
      "has_results": true,
      "last_update_posted_date": "2016-09-13",
      "last_synced_at": "2026-07-22T21:00:42.485Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01557920"
    },
    {
      "nct_id": "NCT04512781",
      "title": "Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dyspnea",
        "Hypercapnia",
        "Respiratory Insufficiency"
      ],
      "interventions": [
        {
          "name": "Control Cannula - Prosoft Cannula - Unicorn Cannula",
          "type": "DEVICE"
        },
        {
          "name": "Control Cannula - Unicorn Cannula - Prosoft Cannula",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vapotherm, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 26,
      "start_date": "2020-10-01",
      "completion_date": "2022-06-07",
      "has_results": true,
      "last_update_posted_date": "2024-02-23",
      "last_synced_at": "2026-07-22T21:00:42.485Z",
      "location_count": 2,
      "location_summary": "Pittsburgh, Pennsylvania • Chattanooga, Tennessee",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Chattanooga",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04512781"
    },
    {
      "nct_id": "NCT03552133",
      "title": "Variable Dead Space Rebreathing Device to Treat Sleep Apnea",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Apnea, Obstructive",
        "Sleep Apnea, Central"
      ],
      "interventions": [
        {
          "name": "Smart CO2",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 13,
      "start_date": "2016-08",
      "completion_date": "2019-10-01",
      "has_results": false,
      "last_update_posted_date": "2019-12-18",
      "last_synced_at": "2026-07-22T21:00:42.485Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03552133"
    }
  ]
}