{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypernatremia",
    "query": {
      "condition": "Hypernatremia"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T16:52:41.387Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01617798",
      "title": "Stop Hypernatremia, Use Metolazone, for Aggressive, Controlled, Effective Diuresis",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Failure",
        "Volume Overload",
        "Hypernatremia"
      ],
      "interventions": [
        {
          "name": "Supplemental metolazone diuresis",
          "type": "DRUG"
        },
        {
          "name": "Placebo Comparator: Control-- furosemide (lasix) only",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 0,
      "start_date": "2012-06",
      "completion_date": "2013-06",
      "has_results": false,
      "last_update_posted_date": "2019-06-06",
      "last_synced_at": "2026-06-10T16:52:41.387Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01617798"
    },
    {
      "nct_id": "NCT06995144",
      "title": "Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Heart Failure",
        "Edema",
        "Pulmonary Congestion",
        "Fluid Overload"
      ],
      "interventions": [
        {
          "name": "Extended Release Torsemide Tablets",
          "type": "DRUG"
        },
        {
          "name": "Immedate Release Torsemide Tablets",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sarfez Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2025-05-28",
      "completion_date": "2025-12-30",
      "has_results": false,
      "last_update_posted_date": "2026-03-10",
      "last_synced_at": "2026-06-10T16:52:41.387Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06995144"
    },
    {
      "nct_id": "NCT04233957",
      "title": "Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sodium Excess"
      ],
      "interventions": [
        {
          "name": "High Sodium",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "University of Delaware",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "21 Years to 45 Years"
      },
      "enrollment_count": 50,
      "start_date": "2020-01-01",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-11-29",
      "last_synced_at": "2026-06-10T16:52:41.387Z",
      "location_count": 1,
      "location_summary": "Newark, Delaware",
      "locations": [
        {
          "city": "Newark",
          "state": "Delaware"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04233957"
    },
    {
      "nct_id": "NCT01219179",
      "title": "Use of Sterile Water Feeds for Treatment of Hypernatremia in Extremely Low Birth Weight Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Extremely Low Birth Weight Infants",
        "Hypernatremia"
      ],
      "interventions": [
        {
          "name": "Sterile water feedings",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "24 Hours",
        "maximum_age": "28 Weeks",
        "sex": "ALL",
        "summary": "24 Hours to 28 Weeks"
      },
      "enrollment_count": 19,
      "start_date": "2010-11",
      "completion_date": "2012-08",
      "has_results": false,
      "last_update_posted_date": "2013-02-27",
      "last_synced_at": "2026-06-10T16:52:41.387Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01219179"
    },
    {
      "nct_id": "NCT05591612",
      "title": "Increasing Vegetable Intake Using Monosodium Glutamate: A Reduced-Effort Intervention",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy Nutrition",
        "Culinary Medicine",
        "Sodium Excess"
      ],
      "interventions": [
        {
          "name": "Salt replacement seasoning (50% salt and 50% MSG) mix",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Salt replacement seasoning (70% salt and 30% MSG) mix",
          "type": "BEHAVIORAL"
        },
        {
          "name": "NaCl (sodium chloride/table salt)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Texas Tech University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 148,
      "start_date": "2023-02-10",
      "completion_date": "2023-11-15",
      "has_results": false,
      "last_update_posted_date": "2024-08-01",
      "last_synced_at": "2026-06-10T16:52:41.387Z",
      "location_count": 1,
      "location_summary": "Lubbock, Texas",
      "locations": [
        {
          "city": "Lubbock",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05591612"
    },
    {
      "nct_id": "NCT04244604",
      "title": "Vascular Effects of Acute Sodium (VEAS) Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sodium Excess",
        "Racial Disparities",
        "Blood Pressure",
        "Cardiovascular Risk Factor"
      ],
      "interventions": [
        {
          "name": "Low Sodium Meal (140 mg sodium chloride)",
          "type": "OTHER"
        },
        {
          "name": "High Sodium Meal (2500 mg sodium chloride)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "19 Years to 75 Years"
      },
      "enrollment_count": 71,
      "start_date": "2021-05-03",
      "completion_date": "2025-12-15",
      "has_results": false,
      "last_update_posted_date": "2025-12-19",
      "last_synced_at": "2026-06-10T16:52:41.387Z",
      "location_count": 2,
      "location_summary": "Auburn, Alabama • Bloomington, Indiana",
      "locations": [
        {
          "city": "Auburn",
          "state": "Alabama"
        },
        {
          "city": "Bloomington",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04244604"
    },
    {
      "nct_id": "NCT01564238",
      "title": "Effect of Sodium Intake on Calcium Retention in Girls",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoporosis"
      ],
      "interventions": [
        {
          "name": "Low Na diet (1.3 g/d)",
          "type": "OTHER"
        },
        {
          "name": "High sodium diet (3.8 g/d)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Purdue University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "15 Years",
        "sex": "FEMALE",
        "summary": "11 Years to 15 Years · Female only"
      },
      "enrollment_count": 67,
      "start_date": "1999-01",
      "completion_date": "2000-08",
      "has_results": false,
      "last_update_posted_date": "2018-05-09",
      "last_synced_at": "2026-06-10T16:52:41.387Z",
      "location_count": 1,
      "location_summary": "West Lafayette, Indiana",
      "locations": [
        {
          "city": "West Lafayette",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01564238"
    },
    {
      "nct_id": "NCT04598386",
      "title": "The Effect of AMP Human Sodium Bicarbonate Lotion on Hydration",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fluid Retention",
        "Fluid Loss",
        "Sodium Retention",
        "Cognitive Change",
        "Heat Exposure",
        "Hyperhydration",
        "Electrolyte and Fluid Balance Conditions"
      ],
      "interventions": [
        {
          "name": "PR Lotion - AMP Human Performance",
          "type": "OTHER"
        },
        {
          "name": "Placebo Lotion",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Connecticut",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "MALE",
        "summary": "18 Years to 35 Years · Male only"
      },
      "enrollment_count": 20,
      "start_date": "2020-12-09",
      "completion_date": "2021-04-09",
      "has_results": false,
      "last_update_posted_date": "2021-10-14",
      "last_synced_at": "2026-06-10T16:52:41.387Z",
      "location_count": 1,
      "location_summary": "Storrs, Connecticut",
      "locations": [
        {
          "city": "Storrs",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04598386"
    },
    {
      "nct_id": "NCT02084797",
      "title": "V2 Receptor Effects on Fluid Regulation and Performance",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electrolyte Imbalance",
        "Hyponatremia",
        "Hypernatremia"
      ],
      "interventions": [
        {
          "name": "V2R (Vasopressin 2 receptor)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Oakland University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 10,
      "start_date": "2011-06",
      "completion_date": "2012-10",
      "has_results": true,
      "last_update_posted_date": "2016-05-12",
      "last_synced_at": "2026-06-10T16:52:41.387Z",
      "location_count": 1,
      "location_summary": "Rochester, Michigan",
      "locations": [
        {
          "city": "Rochester",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02084797"
    },
    {
      "nct_id": "NCT05092854",
      "title": "The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fluid Retention",
        "Sodium Retention",
        "Heat Stress",
        "Dehydration (Physiology)",
        "Renal Injury",
        "Electrolyte and Fluid Balance Conditions"
      ],
      "interventions": [
        {
          "name": "PR Lotion - AMP Human Performance",
          "type": "OTHER"
        },
        {
          "name": "Placebo Lotion",
          "type": "OTHER"
        },
        {
          "name": "AminoVital - Rapid Recovery",
          "type": "OTHER"
        },
        {
          "name": "Placebo Supplement",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Connecticut",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "MALE",
        "summary": "18 Years to 45 Years · Male only"
      },
      "enrollment_count": 18,
      "start_date": "2021-09-03",
      "completion_date": "2022-08-01",
      "has_results": false,
      "last_update_posted_date": "2022-10-24",
      "last_synced_at": "2026-06-10T16:52:41.387Z",
      "location_count": 1,
      "location_summary": "Storrs, Connecticut",
      "locations": [
        {
          "city": "Storrs",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05092854"
    }
  ]
}