{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hyperpigmentation",
    "query": {
      "condition": "Hyperpigmentation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 86,
    "total_pages": 9,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hyperpigmentation&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:04:23.423Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02947022",
      "title": "Effects of IV-Administered Ca-DTPA and Zn-DTPA To Treat Patients With Gadolinium Deposition Disease",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Headache",
        "Cognitive Disturbance",
        "Skin Hyperpigmentation",
        "Arthralgia"
      ],
      "interventions": [
        {
          "name": "Calcium DTPA",
          "type": "DRUG"
        },
        {
          "name": "Zinc DTPA",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 1,
      "start_date": "2016-10",
      "completion_date": "2017-01-31",
      "has_results": true,
      "last_update_posted_date": "2018-04-06",
      "last_synced_at": "2026-05-22T09:04:23.423Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02947022"
    },
    {
      "nct_id": "NCT02977507",
      "title": "Split-face Study Comparing the Cosmetic Efficacy and Tolerability of Two Topical Products in Participants With Moderate Facial Melasma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Lytera 2.0",
          "type": "OTHER"
        },
        {
          "name": "4% Hydroquinone Topical Cream",
          "type": "DRUG"
        },
        {
          "name": "SkinMedica Facial Cleanser",
          "type": "OTHER"
        },
        {
          "name": "SkinMedica Rejuvenative Moisturizer",
          "type": "OTHER"
        },
        {
          "name": "SkinMedica Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Allergan",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2016-12-13",
      "completion_date": "2017-10-09",
      "has_results": true,
      "last_update_posted_date": "2018-12-19",
      "last_synced_at": "2026-05-22T09:04:23.423Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02977507"
    },
    {
      "nct_id": "NCT02763072",
      "title": "A Single-Center 2-Arm Study for Lentigines on the Hands",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lentigines"
      ],
      "interventions": [
        {
          "name": "Enlighten Laser",
          "type": "DEVICE"
        },
        {
          "name": "Excel V Laser",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cutera Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "30 Years to 90 Years"
      },
      "enrollment_count": 24,
      "start_date": "2016-04",
      "completion_date": "2017-06-26",
      "has_results": true,
      "last_update_posted_date": "2023-06-02",
      "last_synced_at": "2026-05-22T09:04:23.423Z",
      "location_count": 1,
      "location_summary": "Naperville, Illinois",
      "locations": [
        {
          "city": "Naperville",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02763072"
    },
    {
      "nct_id": "NCT02206360",
      "title": "Pancreatic Cancer Early Detection Program",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pancreatic Cancer",
        "Pancreas Cancer",
        "Pancreatic Adenocarcinoma",
        "Familial Pancreatic Cancer",
        "BRCA 1/2",
        "HNPCC",
        "Lynch Syndrome",
        "Hereditary Pancreatitis",
        "FAMMM",
        "Familial Atypical Multiple Mole Melanoma",
        "Peutz Jeghers Syndrome"
      ],
      "interventions": [
        {
          "name": "Endoscopic Ultrasound",
          "type": "PROCEDURE"
        },
        {
          "name": "Magnetic Resonance Imaging (MRI)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "White Plains Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2014-04",
      "completion_date": "2024-06",
      "has_results": false,
      "last_update_posted_date": "2024-05-24",
      "last_synced_at": "2026-05-22T09:04:23.423Z",
      "location_count": 1,
      "location_summary": "White Plains, New York",
      "locations": [
        {
          "city": "White Plains",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02206360"
    },
    {
      "nct_id": "NCT01334125",
      "title": "Adjunctive Metformin Therapy in Double Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Diabetes Mellitus"
      ],
      "interventions": [
        {
          "name": "Metformin",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Massachusetts, Worcester",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "10 Years to 20 Years"
      },
      "enrollment_count": 28,
      "start_date": "2011-02",
      "completion_date": "2014-12",
      "has_results": true,
      "last_update_posted_date": "2016-03-04",
      "last_synced_at": "2026-05-22T09:04:23.423Z",
      "location_count": 1,
      "location_summary": "Worcester, Massachusetts",
      "locations": [
        {
          "city": "Worcester",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01334125"
    },
    {
      "nct_id": "NCT02095756",
      "title": "Combination Alexandrite Laser and Topical Therapy vs Topical Therapy Alone for Treatment of Melasma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "755nm Alexandrite Laser and Lytera Skin Brightening System (Non-Hydroquinone Topical Therapy)",
          "type": "OTHER"
        },
        {
          "name": "Lytera Skin Brightening System (Non-hydroquinone topical therapy)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Cynosure, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "74 Years",
        "sex": "ALL",
        "summary": "18 Years to 74 Years"
      },
      "enrollment_count": 20,
      "start_date": "2013-06",
      "completion_date": "2014-06",
      "has_results": false,
      "last_update_posted_date": "2015-07-31",
      "last_synced_at": "2026-05-22T09:04:23.423Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02095756"
    },
    {
      "nct_id": "NCT02730819",
      "title": "Topical Composition Therapy (2013-MCN-333) for the Treatment of Melasma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Illuminate Cream",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 19,
      "start_date": "2016-05-15",
      "completion_date": "2016-12-30",
      "has_results": true,
      "last_update_posted_date": "2017-10-20",
      "last_synced_at": "2026-05-22T09:04:23.423Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02730819"
    },
    {
      "nct_id": "NCT05423873",
      "title": "A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment for Facial Hyperpigmentation and Photodamaged Skin in Patients Exposed to Extrinsic Factors of Aging",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hyperpigmentation",
        "Photodamaged Skin",
        "Wrinkle",
        "Fine Lines"
      ],
      "interventions": [
        {
          "name": "Gentle Cleansing Lotion, Revision Skincare",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Revision Skincare",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "35 Years to 60 Years · Female only"
      },
      "enrollment_count": 33,
      "start_date": "2021-03-17",
      "completion_date": "2022-02-10",
      "has_results": false,
      "last_update_posted_date": "2022-06-21",
      "last_synced_at": "2026-05-22T09:04:23.423Z",
      "location_count": 3,
      "location_summary": "Solana Beach, California • Greenwood Village, Colorado • Nashville, Tennessee",
      "locations": [
        {
          "city": "Solana Beach",
          "state": "California"
        },
        {
          "city": "Greenwood Village",
          "state": "Colorado"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05423873"
    },
    {
      "nct_id": "NCT03456674",
      "title": "LaseMD System for the Treatment of Melasma",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "LaseMD System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "CynosureLutronic",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2018-02-07",
      "completion_date": "2019-06-30",
      "has_results": false,
      "last_update_posted_date": "2019-03-13",
      "last_synced_at": "2026-05-22T09:04:23.423Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03456674"
    },
    {
      "nct_id": "NCT07136766",
      "title": "An 18-week Study to Evaluate a Test Product With a Marketed Prescription Product",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Hyperpigmentation"
      ],
      "interventions": [
        {
          "name": "Facial Toner",
          "type": "DRUG"
        },
        {
          "name": "Placebo Toner",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Good Molecules, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 75 Years · Female only"
      },
      "enrollment_count": 40,
      "start_date": "2025-09-10",
      "completion_date": "2026-02-16",
      "has_results": false,
      "last_update_posted_date": "2025-08-22",
      "last_synced_at": "2026-05-22T09:04:23.423Z",
      "location_count": 1,
      "location_summary": "Teaneck, New Jersey",
      "locations": [
        {
          "city": "Teaneck",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07136766"
    }
  ]
}