{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hyperpigmentation&page=4",
    "query": {
      "condition": "Hyperpigmentation",
      "page": 4
    },
    "page_size": 10
  },
  "pagination": {
    "page": 4,
    "page_size": 10,
    "total_count": 89,
    "total_pages": 9,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hyperpigmentation&page=5&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hyperpigmentation&page=3&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-22T13:20:35.325Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00641420",
      "title": "Safety and Efficacy of 1550nm Fractional Laser Treatment for Acne Scars in Fitzpatrick Type IV-VI Skin",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acne Scarring"
      ],
      "interventions": [
        {
          "name": "Fractionated Laser Resurfacing",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Henry Ford Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "18 Years to 59 Years"
      },
      "enrollment_count": 15,
      "start_date": "2007-09",
      "completion_date": "2008-09",
      "has_results": false,
      "last_update_posted_date": "2022-03-15",
      "last_synced_at": "2026-10-22T13:20:35.325Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00641420"
    },
    {
      "nct_id": "NCT07807085",
      "title": "Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Skin Barrier to Water Loss",
        "Skin Health",
        "Skin Discoloration",
        "Skin Irritation",
        "Skin Abnormalities",
        "Hyperpigmentation",
        "Hyperpigmentation; Melanin",
        "Stretch Mark",
        "Breast Reconstruction",
        "Breast Augmentation and Breast Reconstruction",
        "Chemotherapy Effects",
        "Lymphatic Abnormalities"
      ],
      "interventions": [
        {
          "name": "Apple Peptide Complex Post-Aesthetic Care Protocol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Grow Out Oils Clinical Aromatherapy Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 50,
      "start_date": "2021-01-20",
      "completion_date": "2025-12-29",
      "has_results": false,
      "last_update_posted_date": "2026-09-08",
      "last_synced_at": "2026-10-22T13:20:35.325Z",
      "location_count": 1,
      "location_summary": "Weston, Florida",
      "locations": [
        {
          "city": "Weston",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07807085"
    },
    {
      "nct_id": "NCT00669071",
      "title": "Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in Melasma",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%",
          "type": "DRUG"
        },
        {
          "name": "Cetaphil® Moisturizing Cream as Inactive Control",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Galderma R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "74 Years",
        "sex": "ALL",
        "summary": "18 Years to 74 Years"
      },
      "enrollment_count": 56,
      "start_date": "2008-01",
      "completion_date": "2008-10",
      "has_results": true,
      "last_update_posted_date": "2022-08-23",
      "last_synced_at": "2026-10-22T13:20:35.325Z",
      "location_count": 2,
      "location_summary": "La Jolla, California • Nashville, Tennessee",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00669071"
    },
    {
      "nct_id": "NCT07644871",
      "title": "A 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face Hyperpigmentation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hyperpigmentation",
        "Melasma",
        "Dark Spots"
      ],
      "interventions": [
        {
          "name": "Facial Cleanser",
          "type": "OTHER"
        },
        {
          "name": "Facial Moisturizer",
          "type": "OTHER"
        },
        {
          "name": "Sunscreen SPF 55",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Revision Skincare",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "20 Years to 60 Years · Female only"
      },
      "enrollment_count": 18,
      "start_date": "2025-08-11",
      "completion_date": "2025-11-12",
      "has_results": false,
      "last_update_posted_date": "2026-06-12",
      "last_synced_at": "2026-10-22T13:20:35.325Z",
      "location_count": 1,
      "location_summary": "Irving, Texas",
      "locations": [
        {
          "city": "Irving",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07644871"
    },
    {
      "nct_id": "NCT05704114",
      "title": "Tazarotene 0.045% Lotion for Treating PIE and PIH in Subjects With Acne",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Acne Vulgaris",
        "Post Inflammatory Hyperpigmentation",
        "Post Inflammatory Pigmentation Change",
        "Erythema",
        "Skin Scarring"
      ],
      "interventions": [
        {
          "name": "Tazarotene 0.045% Lotion",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Dr. Emmy Graber",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 20,
      "start_date": "2021-02-01",
      "completion_date": "2022-05-01",
      "has_results": false,
      "last_update_posted_date": "2023-01-30",
      "last_synced_at": "2026-10-22T13:20:35.325Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05704114"
    },
    {
      "nct_id": "NCT05656833",
      "title": "Combination Topical Cysteamine and Fractional 1927nm Low-Powered Diode Laser for Treatment of Facial Melasma",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Fractional 1927nm Low-Powered Diode Laser",
          "type": "DEVICE"
        },
        {
          "name": "Topical Cysteamine",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "UnionDerm",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "74 Years",
        "sex": "ALL",
        "summary": "18 Years to 74 Years"
      },
      "enrollment_count": 20,
      "start_date": "2022-10-28",
      "completion_date": "2023-07",
      "has_results": false,
      "last_update_posted_date": "2022-12-19",
      "last_synced_at": "2026-10-22T13:20:35.325Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05656833"
    },
    {
      "nct_id": "NCT06415435",
      "title": "Sylfirm X Radiofrequency Microneedling for the Treatment of Melasma",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Radiofrequency Microneedling",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Benev Company, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 70 Years · Female only"
      },
      "enrollment_count": 90,
      "start_date": "2023-05-01",
      "completion_date": "2024-10-01",
      "has_results": false,
      "last_update_posted_date": "2024-05-16",
      "last_synced_at": "2026-10-22T13:20:35.325Z",
      "location_count": 3,
      "location_summary": "La Jolla, California • Charlotte, North Carolina • Houston, Texas",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06415435"
    },
    {
      "nct_id": "NCT02730819",
      "title": "Topical Composition Therapy (2013-MCN-333) for the Treatment of Melasma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Illuminate Cream",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 19,
      "start_date": "2016-05-15",
      "completion_date": "2016-12-30",
      "has_results": true,
      "last_update_posted_date": "2017-10-20",
      "last_synced_at": "2026-10-22T13:20:35.325Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02730819"
    },
    {
      "nct_id": "NCT03953209",
      "title": "Spironolactone for the Treatment of Melasma",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Spironolactone 50Mg Tablet",
          "type": "DRUG"
        },
        {
          "name": "Spironolactone 100Mg Tablet",
          "type": "DRUG"
        },
        {
          "name": "Spironolactone 200Mg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 70 Years · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2020-03-05",
      "completion_date": "2021-01-01",
      "has_results": false,
      "last_update_posted_date": "2024-09-04",
      "last_synced_at": "2026-10-22T13:20:35.325Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03953209"
    },
    {
      "nct_id": "NCT07501000",
      "title": "Evaluation of the Safety and Tolerability of a Brightening Treatment Paired With a Skincare Regimen",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hyperpigmentation",
        "Skin Ageing",
        "Post Inflammatory Hyperpigmentation",
        "Skin Roughness"
      ],
      "interventions": [
        {
          "name": "Brightening Treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Revision Skincare",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "20 Years to 65 Years · Female only"
      },
      "enrollment_count": 11,
      "start_date": "2024-10-07",
      "completion_date": "2025-01-23",
      "has_results": false,
      "last_update_posted_date": "2026-06-05",
      "last_synced_at": "2026-10-22T13:20:35.325Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07501000"
    }
  ]
}