{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypotension+of+Hemodialysis",
    "query": {
      "condition": "Hypotension of Hemodialysis"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 14,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypotension+of+Hemodialysis&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T03:13:37.261Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02182089",
      "title": "Measuring Cardiovascular Stress in Patients on Hemodialysis Study II",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hypotension of Hemodialysis",
        "Hypotension",
        "Estimated Dry Weight",
        "Myocardial Injury",
        "Arrhythmia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Intelomed, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "20 Years and older"
      },
      "enrollment_count": 48,
      "start_date": "2014-04",
      "completion_date": "2023-03-01",
      "has_results": false,
      "last_update_posted_date": "2023-03-03",
      "last_synced_at": "2026-07-23T03:13:37.261Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02182089"
    },
    {
      "nct_id": "NCT05297786",
      "title": "Hemodialysis.-Induced Hypotension Therapy for End Stage Kidney Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hemodialysis Complication",
        "Hypotension of Hemodialysis"
      ],
      "interventions": [
        {
          "name": "Lanadelumab Injection [Takhzyro]",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 28,
      "start_date": "2022-07-27",
      "completion_date": "2024-09-26",
      "has_results": true,
      "last_update_posted_date": "2026-06-29",
      "last_synced_at": "2026-07-23T03:13:37.261Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05297786"
    },
    {
      "nct_id": "NCT03327909",
      "title": "Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "ESRD",
        "Hemodialysis Complication",
        "Blood Pressure"
      ],
      "interventions": [
        {
          "name": "TAKE vs. HOLD",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 131,
      "start_date": "2018-07-16",
      "completion_date": "2019-12-14",
      "has_results": false,
      "last_update_posted_date": "2022-08-23",
      "last_synced_at": "2026-07-23T03:13:37.261Z",
      "location_count": 2,
      "location_summary": "Menlo Park, California • San Carlos, California",
      "locations": [
        {
          "city": "Menlo Park",
          "state": "California"
        },
        {
          "city": "San Carlos",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03327909"
    },
    {
      "nct_id": "NCT05834777",
      "title": "Prevention of Intradialytic Hypotension by Inhibiting Bradykinin B2 Receptor",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Intradialytic Hypotension"
      ],
      "interventions": [
        {
          "name": "Icatibant",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 26,
      "start_date": "2023-12-11",
      "completion_date": "2026-11-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-15",
      "last_synced_at": "2026-07-23T03:13:37.261Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05834777"
    },
    {
      "nct_id": "NCT01520207",
      "title": "Mannitol - Potential Role in Hemodialysis Initiation for Reduction of Intra-dialytic Hypotension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Intra-dialytic Hypotension"
      ],
      "interventions": [
        {
          "name": "Mannitol (20%)",
          "type": "DRUG"
        },
        {
          "name": "0.9% saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 52,
      "start_date": "2012-05",
      "completion_date": "2018-12",
      "has_results": true,
      "last_update_posted_date": "2019-01-30",
      "last_synced_at": "2026-07-23T03:13:37.261Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01520207"
    },
    {
      "nct_id": "NCT05814146",
      "title": "Trial of Variable Dialysate Bicarbonate",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Peri-dialytic Cardiac Rhythms",
        "Intradialytic Hypotension",
        "Electrolyte Changes",
        "pH Changes",
        "Adverse Symptoms"
      ],
      "interventions": [
        {
          "name": "Dialysate bicarbonate concentration",
          "type": "DRUG"
        },
        {
          "name": "Dialysate bicarbonate concentration - telemetry monitoring",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "120 Years",
        "sex": "ALL",
        "summary": "18 Years to 120 Years"
      },
      "enrollment_count": 141,
      "start_date": "2023-08-24",
      "completion_date": "2026-10-01",
      "has_results": false,
      "last_update_posted_date": "2025-11-24",
      "last_synced_at": "2026-07-23T03:13:37.261Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05814146"
    },
    {
      "nct_id": "NCT01168947",
      "title": "Effect of Sodium Concentration of Priming and Rinsing Fluids on Weight Gain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fluid Overload and Hypertension in Hemodialysis Patients"
      ],
      "interventions": [
        {
          "name": "5% dextrose solution",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Renal Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 17,
      "start_date": "2010-07",
      "completion_date": "2012-11",
      "has_results": false,
      "last_update_posted_date": "2017-04-12",
      "last_synced_at": "2026-07-23T03:13:37.261Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01168947"
    },
    {
      "nct_id": "NCT00237783",
      "title": "Safety of Dialysate Sodium Individualization in Hemodialysis Patients With Intradialytic Hypotension",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Hemodialysis",
        "Hypotension"
      ],
      "interventions": [
        {
          "name": "dialysate sodium (140 mmol/L)",
          "type": "DRUG"
        },
        {
          "name": "individualized dialysate sodium",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 4,
      "start_date": "2005-10",
      "completion_date": "2008-10",
      "has_results": false,
      "last_update_posted_date": "2016-07-26",
      "last_synced_at": "2026-07-23T03:13:37.261Z",
      "location_count": 1,
      "location_summary": "West Haven, Connecticut",
      "locations": [
        {
          "city": "West Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00237783"
    },
    {
      "nct_id": "NCT03171545",
      "title": "Enhancing the Cardiovascular Safety of Hemodialysis Care (Dialysafe)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Kidney Failure",
        "End Stage Renal Disease",
        "Hypotension",
        "Cardiovascular Diseases",
        "Patient Safety"
      ],
      "interventions": [
        {
          "name": "Patient Activation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Provider Education",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 1431,
      "start_date": "2023-01-11",
      "completion_date": "2024-12-13",
      "has_results": true,
      "last_update_posted_date": "2026-01-14",
      "last_synced_at": "2026-07-23T03:13:37.261Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03171545"
    },
    {
      "nct_id": "NCT03144817",
      "title": "Dialysate Sodium Lowering Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hemodialysis Complication",
        "Fluid Overload",
        "Dialysis Disequilibrium",
        "Intra-dialytic Hypotension",
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Dialysate Sodium Lowering",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Tufts Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 44,
      "start_date": "2017-04-26",
      "completion_date": "2019-04-02",
      "has_results": false,
      "last_update_posted_date": "2019-06-03",
      "last_synced_at": "2026-07-23T03:13:37.261Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03144817"
    }
  ]
}