{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypothermia%2C+Newborn",
    "query": {
      "condition": "Hypothermia, Newborn"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 41,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypothermia%2C+Newborn&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T08:13:20.902Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05853601",
      "title": "Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Acute Kidney Injury",
        "HIE"
      ],
      "interventions": [
        {
          "name": "Single Dose Theophylline",
          "type": "DRUG"
        },
        {
          "name": "Repeat Dose Theophylline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medical College of Wisconsin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Hour",
        "maximum_age": "18 Hours",
        "sex": "ALL",
        "summary": "1 Hour to 18 Hours"
      },
      "enrollment_count": 30,
      "start_date": "2023-10-17",
      "completion_date": "2027-11",
      "has_results": false,
      "last_update_posted_date": "2026-04-13",
      "last_synced_at": "2026-05-22T08:13:20.902Z",
      "location_count": 1,
      "location_summary": "Oklahoma City, Oklahoma",
      "locations": [
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05853601"
    },
    {
      "nct_id": "NCT00904228",
      "title": "Plastic Hat Trial to Prevent Hypothermia in Preterm Newborns in the Delivery Room",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypothermia"
      ],
      "interventions": [
        {
          "name": "placement of plastic cap during delivery room stabilization",
          "type": "OTHER"
        },
        {
          "name": "placement of routine cap during delivery room stabilization",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "1 Hour",
        "sex": "ALL",
        "summary": "Up to 1 Hour"
      },
      "enrollment_count": 260,
      "start_date": "2008-09",
      "completion_date": "2010-12",
      "has_results": false,
      "last_update_posted_date": "2019-04-25",
      "last_synced_at": "2026-05-22T08:13:20.902Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00904228"
    },
    {
      "nct_id": "NCT03129620",
      "title": "Pharmacokinetics of Ampicillin in Neonates With Moderate to Severe Hypoxic-Ischemic Encephalopathy",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hypothermia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Drexel University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Hours",
        "maximum_age": "24 Hours",
        "sex": "ALL",
        "summary": "6 Hours to 24 Hours"
      },
      "enrollment_count": 14,
      "start_date": "2013-03",
      "completion_date": "2016-04",
      "has_results": false,
      "last_update_posted_date": "2017-04-26",
      "last_synced_at": "2026-05-22T08:13:20.902Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03129620"
    },
    {
      "nct_id": "NCT00005772",
      "title": "Whole-Body Cooling for Birth Asphyxia in Term Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Infant, Newborn",
        "Hypoxia-Ischemia, Brain"
      ],
      "interventions": [
        {
          "name": "Induced hypothermia",
          "type": "DEVICE"
        },
        {
          "name": "Control",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "NICHD Neonatal Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "Up to 6 Hours"
      },
      "enrollment_count": 208,
      "start_date": "1999-10",
      "completion_date": "2010-07",
      "has_results": false,
      "last_update_posted_date": "2019-03-22",
      "last_synced_at": "2026-05-22T08:13:20.902Z",
      "location_count": 16,
      "location_summary": "Birmingham, Alabama • Palo Alto, California • New Haven, Connecticut + 13 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00005772"
    },
    {
      "nct_id": "NCT05609292",
      "title": "Testing A Visual Thermometer in Newborns and Young Infants",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hyperthermia",
        "Hypothermia"
      ],
      "interventions": [
        {
          "name": "observational",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "0 Months",
        "maximum_age": "6 Months",
        "sex": "ALL",
        "summary": "0 Months to 6 Months"
      },
      "enrollment_count": 120,
      "start_date": "2022-12-05",
      "completion_date": "2023-09-30",
      "has_results": false,
      "last_update_posted_date": "2023-11-28",
      "last_synced_at": "2026-05-22T08:13:20.902Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05609292"
    },
    {
      "nct_id": "NCT05295784",
      "title": "PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Acute Kidney Injury",
        "Hypoxic-Ischemic Encephalopathy",
        "Caffeine"
      ],
      "interventions": [
        {
          "name": "Caffeine citrate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Arkansas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Hours",
        "maximum_age": "24 Hours",
        "sex": "ALL",
        "summary": "0 Hours to 24 Hours"
      },
      "enrollment_count": 0,
      "start_date": "2024-05-08",
      "completion_date": "2024-05-08",
      "has_results": false,
      "last_update_posted_date": "2024-05-10",
      "last_synced_at": "2026-05-22T08:13:20.902Z",
      "location_count": 2,
      "location_summary": "Little Rock, Arkansas",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05295784"
    },
    {
      "nct_id": "NCT00620711",
      "title": "Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Hypoxic Ischemic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Olympic Cool Cap",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Minutes",
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "30 Minutes to 6 Hours"
      },
      "enrollment_count": 4,
      "start_date": "2008-02",
      "completion_date": "2013-07",
      "has_results": true,
      "last_update_posted_date": "2019-01-29",
      "last_synced_at": "2026-05-22T08:13:20.902Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00620711"
    },
    {
      "nct_id": "NCT05778188",
      "title": "A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hypoxic-Ischemic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "RLS-0071",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "ReAlta Life Sciences, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "10 Hours",
        "sex": "ALL",
        "summary": "Up to 10 Hours"
      },
      "enrollment_count": 70,
      "start_date": "2023-07-27",
      "completion_date": "2028-12",
      "has_results": false,
      "last_update_posted_date": "2026-04-13",
      "last_synced_at": "2026-05-22T08:13:20.902Z",
      "location_count": 15,
      "location_summary": "Little Rock, Arkansas • Orange, California • San Diego, California + 11 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05778188"
    },
    {
      "nct_id": "NCT03409770",
      "title": "Optimising the Duration of Cooling in Mild Encephalopathy",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neonatal Encephalopathy",
        "Hypothermia Neonatal",
        "Magnetic Resonance Spectroscopy"
      ],
      "interventions": [
        {
          "name": "Therapeutic hypothermia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Thayyil, Sudhin",
      "sponsor_class": "INDIV",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "Up to 6 Hours"
      },
      "enrollment_count": 140,
      "start_date": "2019-10-10",
      "completion_date": "2024-08-30",
      "has_results": false,
      "last_update_posted_date": "2023-08-04",
      "last_synced_at": "2026-05-22T08:13:20.902Z",
      "location_count": 1,
      "location_summary": "Michigan Center, Michigan",
      "locations": [
        {
          "city": "Michigan Center",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03409770"
    },
    {
      "nct_id": "NCT02621944",
      "title": "Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Hypoxic Ischemic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Melatonin",
          "type": "DRUG"
        },
        {
          "name": "Magnetic Resonance Imaging",
          "type": "OTHER"
        },
        {
          "name": "Pharmacokinetics",
          "type": "OTHER"
        },
        {
          "name": "Neurological Outcome Assessment",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "Up to 6 Hours"
      },
      "enrollment_count": 70,
      "start_date": "2016-11",
      "completion_date": "2026-03",
      "has_results": false,
      "last_update_posted_date": "2025-10-02",
      "last_synced_at": "2026-05-22T08:13:20.902Z",
      "location_count": 2,
      "location_summary": "Gainesville, Florida • Orlando, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02621944"
    }
  ]
}