{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypoxemic+Respiratory+Failure&page=2",
    "query": {
      "condition": "Hypoxemic Respiratory Failure",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypoxemic+Respiratory+Failure&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T04:14:32.133Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05853068",
      "title": "Assessment of PaO2/FiO2 Ratio Pre and POst INTubation",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acute Hypoxemic Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Mechanical ventilation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Dr. Negrin University Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 400,
      "start_date": "2023-04-29",
      "completion_date": "2025-11-30",
      "has_results": false,
      "last_update_posted_date": "2025-08-26",
      "last_synced_at": "2026-05-22T04:14:32.133Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05853068"
    },
    {
      "nct_id": "NCT02951130",
      "title": "Milrinone in Congenital Diaphragmatic Hernia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Congenital Diaphragmatic Hernia",
        "Persistent Pulmonary Hypertension of the Newborn",
        "Hypoxemic Respiratory Failure",
        "Pulmonary Hypoplasia"
      ],
      "interventions": [
        {
          "name": "Milrinone",
          "type": "DRUG"
        },
        {
          "name": "Placebo (5% Dextrose)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NICHD Neonatal Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Hours",
        "maximum_age": "168 Hours",
        "sex": "ALL",
        "summary": "0 Hours to 168 Hours"
      },
      "enrollment_count": 66,
      "start_date": "2017-10-24",
      "completion_date": "2025-05-19",
      "has_results": true,
      "last_update_posted_date": "2025-11-06",
      "last_synced_at": "2026-05-22T04:14:32.133Z",
      "location_count": 19,
      "location_summary": "Birmingham, Alabama • Palo Alto, California • Atlanta, Georgia + 15 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Kansas City",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02951130"
    },
    {
      "nct_id": "NCT04398290",
      "title": "iNOPulse for COVID-19",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "COVID-19",
        "Hypoxemia",
        "Hypoxemic Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Inhaled nitric oxide (iNO)",
          "type": "DRUG"
        },
        {
          "name": "Nitrogen gas",
          "type": "DRUG"
        },
        {
          "name": "Oxygen gas",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Roger Alvarez",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2020-12-01",
      "completion_date": "2021-07-15",
      "has_results": false,
      "last_update_posted_date": "2020-08-19",
      "last_synced_at": "2026-05-22T04:14:32.133Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04398290"
    },
    {
      "nct_id": "NCT04694638",
      "title": "Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prone Positioning",
        "Covid19",
        "Hypoxemic Respiratory Failure",
        "ARDS",
        "Non Invasive Ventilation",
        "High Flow Nasal Cannulla"
      ],
      "interventions": [
        {
          "name": "Body position change",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "110 Years",
        "sex": "ALL",
        "summary": "18 Years to 110 Years"
      },
      "enrollment_count": 6,
      "start_date": "2020-05-21",
      "completion_date": "2023-05-10",
      "has_results": false,
      "last_update_posted_date": "2023-10-05",
      "last_synced_at": "2026-05-22T04:14:32.133Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04694638"
    },
    {
      "nct_id": "NCT07019987",
      "title": "Adiposity Distribution in Acute Respiratory Failure",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Hypoxemic Respiratory Failure",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "PEEP Titration Using Electrical Impedance Tomography (EIT)",
          "type": "OTHER"
        },
        {
          "name": "Body Positioning: Supine and Prone",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "PROCEDURE"
      ],
      "sponsor": "Maurizio F. Cereda, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 80,
      "start_date": "2028-01-01",
      "completion_date": "2030-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-06-13",
      "last_synced_at": "2026-05-22T04:14:32.133Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07019987"
    },
    {
      "nct_id": "NCT04344561",
      "title": "Incline Positioning in COVID-19 Patients for Improvement in Oxygen Saturation",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "COVID",
        "Hypoxic Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Postural Positioning",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 7,
      "start_date": "2020-05-25",
      "completion_date": "2022-05-01",
      "has_results": false,
      "last_update_posted_date": "2022-06-06",
      "last_synced_at": "2026-05-22T04:14:32.133Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04344561"
    },
    {
      "nct_id": "NCT00598429",
      "title": "Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Infant, Newborn",
        "Respiratory Insufficiency",
        "Pulmonary Hypertension",
        "Respiratory Distress Syndrome, Newborn",
        "Streptococcal Infections"
      ],
      "interventions": [
        {
          "name": "Inhaled Prostaglandin E1",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NICHD Neonatal Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "7 Days",
        "sex": "ALL",
        "summary": "Up to 7 Days"
      },
      "enrollment_count": 0,
      "start_date": "2008-05",
      "completion_date": "2008-09",
      "has_results": false,
      "last_update_posted_date": "2019-03-22",
      "last_synced_at": "2026-05-22T04:14:32.133Z",
      "location_count": 11,
      "location_summary": "Birmingham, Alabama • Palo Alto, California • Iowa City, Iowa + 7 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00598429"
    },
    {
      "nct_id": "NCT05880836",
      "title": "In Line Aerosol Nebulization With High Flow",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypoxemic Respiratory Failure",
        "Airway Obstruction"
      ],
      "interventions": [
        {
          "name": "nebulizer via in-line drug delivery maintaining high-flow nasal cannula oxygen",
          "type": "DEVICE"
        },
        {
          "name": "standard jet nebulization (SJN) with face mask",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2023-09-01",
      "completion_date": "2025-01-01",
      "has_results": false,
      "last_update_posted_date": "2025-08-11",
      "last_synced_at": "2026-05-22T04:14:32.133Z",
      "location_count": 2,
      "location_summary": "Los Angeles, California • Santa Monica, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Santa Monica",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05880836"
    },
    {
      "nct_id": "NCT04349332",
      "title": "Early Extubation for Patients With Acute Hypoxemic Respiratory Failure",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mechanical Ventilation",
        "Corona Virus Infection"
      ],
      "interventions": [
        {
          "name": "Helmet non-invasive ventilation (NIV)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2020-08-13",
      "completion_date": "2024-01-09",
      "has_results": false,
      "last_update_posted_date": "2024-05-02",
      "last_synced_at": "2026-05-22T04:14:32.133Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04349332"
    },
    {
      "nct_id": "NCT05074875",
      "title": "COVID-19 Respiratory Outcomes Registry",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Covid19"
      ],
      "interventions": [
        {
          "name": "Questionnaires and Patient Reported Outcomes (PROs)",
          "type": "OTHER"
        },
        {
          "name": "Nasal Swab COVID-19 reverse transcription polymerase chain reaction test (RT-PCR)",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Blood Samples for Biomarkers",
          "type": "GENETIC"
        },
        {
          "name": "High Resolution Computed Tomography",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Physical Exam and Vital Signs",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Medical Research Council Sum Score",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Hand Grip Strength",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Spirometry",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Diffusing Capacity of Carbon Monoxide",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "6 Minute Walk Test",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Sit to Stand (STS) Measurement",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DIAGNOSTIC_TEST",
        "GENETIC"
      ],
      "sponsor": "Weill Medical College of Cornell University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 37,
      "start_date": "2021-01-15",
      "completion_date": "2023-05-09",
      "has_results": false,
      "last_update_posted_date": "2023-07-27",
      "last_synced_at": "2026-05-22T04:14:32.133Z",
      "location_count": 4,
      "location_summary": "St Louis, Missouri • New York, New York • Houston, Texas",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05074875"
    }
  ]
}